摘要:

SUMMARY.—Ten elderly male patients with severe persistent photosensitivity of unknown cause are described. The clinical presentation was that of an intense eczematous eruption affecting exposed sites but spreading elsewhere. Frequent episodes of erythroderma were characteristic and in some cases the marked thickening and ridging of the exposed skin simulated a lymphoma. In contrast to most other photodermatoses the photosensitivity extended through the u.v. to the visible spectrum. A wide range of histological changes were noted, in several instances closely resembling lymphoma because of the intensity and pleomorphism of the infiltrat

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb16022.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—A case of hydroa vacciniforme occurring in association with Hartnup disease is described.The literature on hydroa vacciniforme is reviewed and it is concluded that it constitutes a distinct entity.The occurrence of aminoaciduria in photodermatoses is discusse

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb16023.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—Direct immunofluorescent technique applied to skin sections revealed the occurrence of granular deposits of immunoglobulins in the basement membrane zone of the uninvolved skin from 10 of 12 patients with dermatitis herpetiformis, whereas sections from all 12 patients with pemphigoid yielded a homogeneous immunofluorescent staining pattern.By indirect immunofluorescent technique “basement membrane antibodies” could be demonstrated in the sera from only 7 of 12 patients with pemphigoid.The implications of thein vivooccurrence of immunoglobulins with regard to the pathogenesis of dermatitis herpetiformis and the possibilities for diagnostic applications of the presented findings are disc

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb16024.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—The fine structure of periderm and germinative cells of the bilaminar epidermis of a 14 mm. human embryo is described. Desmosomes at different stages of differentiation are present at intervals along the apposed plasma membranes of cells of both layers, but hemi‐desmosomes have not yet developed along the basal plasma membranes of the germinative cells. Cytoplasmic tono‐filaments are not diffusely distributed within the germinative cells, but a continuous band of filamentous material lies just within, and parallel with the basal plasma membrane. Cells occasionally present between periderm and germinative layers exhibit features suggesting they may be immigrant mesenchymal ele

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb16025.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—The hair follicles and sebaceous glands have been studied in serial sections of normal skin and of skin from subjects with acne and with sebaceous hyperplasia.Keratinization of sebaceous ducts can be observed in normal skin.There is no constant correlation between perifollicular infiltrate, follicular obstruction and the development of comedones.Rupture of a cyst wall can occur in follicles with patent ostia. Localized loss of granular layer in the cyst wall indicates a defect in keratinization preceding ruptur

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb16026.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—Samples of sebum from 6 young men with acne vulgaris were analysed before and after systemic treatment with tetracycline for 4 and for 8 weeks.The rate of sebum production was not significantly changed. At 4 weeks there was a consistent fall in the free fatty acids and a slight rise in the triglycerides. After 8 weeks there was a marked fall in the aliphatic alcohol ester fractio

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb16027.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—Specimens of skin were assayed by the method of Mier and Wood (1969) for hyaluronic acid and chondroitin sulphate.No major variations in the concentration of these substances were found to occur in different mammalian species, different sites of the body, or between animals of different ages. In general, the normal ranges were quite narrow; the widest variation occurred in human skin. Most of the acid mucopoly‐saccharides were shown to be located in the dermis, the concentration in the epidermis being very low.These results have been discussed in the light of the existing literature on acid mucopolysacchari

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb16028.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—The mechanism by which the Koebner reaction could be provoked was studied in 6 patients with active psoriasis. It was concluded that purely epidermal or purely dermal damage was ineffective but that damage of the basement membrane was not essential. The factors determining a successful reaction are not clear. Injury of both epidermis and dermis appears to be essential but it is perhaps the degree of tissue damage which is importan

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb16029.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—The disadvantages of certain variable factors influencing the reliability of traditional patch test techniques have been discussed.Further experience of the use of a glycogelatin vehicle for patch testing is reported.Difficulties were encountered in incorporating some allergens in the glycogelatin vehicle but in general the technique proved satisfactor

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb16030.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—Twenty‐three cases of dermatomyositis are reported of which 12 (52%) were associated with internal malignancy. In the patients over 40 years of age, malignant diseases were encountered in 69%, while only one of 7 cases under 40 had associated malignancy. Nasopharyngeal carcinoma accounted for 75% of the malignant disease.A distinctive skin eruption, consisting of hyperkeratotic, follicular, erythematous papules, is described. On the face, trunk and limbs, the papules tended to become confluent. Along the tendons and over the bony prominences on the backs of the hands and feet, the eruption was usually arranged in a linear fashion. There was alopecia of the scalp. On the palms and soles were hyperkeratotic papules or plaques. The occurrence of this form of eruption in dermatomyositis may be influenced by racial fact

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb16031.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY