摘要:

SUMMARYA new immunoperoxidase staining technique of high specificity (the labelled antigen method) has been used for the detection of serum proteins in the epithelium of human skin and mucous membranes. The majority of specimens contain cells showing strong diffuse intracellular staining. These cells usually lie in the upper mid‐zone of the epithelium and are often characterized by vacuolated or pyknotic nuclei. Double immunoenzymatic labelling (using alkaline phosphatase and peroxidase) showed that the different proteins are usually present in the same cells. A less frequent pattern of staining took the form of delicate strands of intercellular IgG.Samples from a wide range of skin diseases were studied, but no clear relationship between positive epithelial staining and disease states was apparent. It is suggested that serum proteins may enter epithelial cells by passive diffusion, and attention is drawn to other instances (e. g. in the central nervous system and lymphoid tissue) where similar phenomena have been observed by immunoenzymatic staining technique

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb07646.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYG‐banded chromosome analysis was performed on peripheral blood lymphocytes after phytohaemagglutinin stimulation from sixteen patients with mycosis fungoides. A number of chromosome abnormalities were observed in a low proportion of blood lymphocytes in seven patients in later stages of the disease. In four patients similar marker chromosomes in multiple copies were present, some of them without a clearly visible centromere.We conclude that a correlation exists between the presence of chromosome abnormalities in circulating blood lymphocytes and the course of the diseas

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb07647.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYA series of twenty‐four cases of transient acantholytic dermatosis (TAD) is presented. All patients were male and their eruptions tended to be more persistent than those of previously reported cases. The epidermal changes included four patterns of acantholysis, of which the pemphigus‐like pattern was associated with the more persistent eruptions. Although twenty‐three of the twenty‐four patients had other actinic‐associated skin lesions, no direct relationship between the onset of TAD and episodes of excessive sun exposure was found. Oral vitamin A treatment has been effective in s

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb07648.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYFive skin and two oral biopsies from patients with South American pemphigus foliaceus (SAPF) were studied by electron and immunoelectron microscopy for the ultrastructural localization of bound immunoglobulin in epidermal and oral lesions.Electron microscopy showed the tonofilament‐desmosome complex to be preserved in the various layers of the epidermis. Immunoglobulin was bound over the plasma membrane and permeated the desmosomal junctions both in the skin and oral mucosa, thus suggesting that pemphigus antibodies are attached to the glycocalyx. It appears that the initial injury in SAPF acantholysis involves the glycocalyx and that it might be caused by interaction with intercellular antibodies present in the patient's seru

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb07649.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYFour African female patients are described, who presented with the features of systemic sclerosis. Overlapping features of lupus erythematosus or dermatomyositis were present in three cases but were not prominent. Direct immunofluorescence of uninvolved skin revealed a particulate (or speckled) epidermal nuclear staining, with specificity for IgG. In view of the reported association between this finding and mixed connective tissue disease, these patients were treated with corticosteroids and marked improvement occurred in all cases. The usefulness of this investigation in making the distinction between systemic sclerosis and mixed connective tissue disease and in indicating a potentially effective form of therapy is discussed.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb07650.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYUltraviolet light (UV)‐exposed rabbit skin was stained with a fluorescent thiol reagent or haematoxylin and eosin to investigate a time relationship between histochemical stainings for sulphhydryl (‐SH) and disulphide (S‐S) groups and sunburn cell (SBC) production. SBCs appeared by 8 h after irradiation, increased and showed a peak at 48 h, then declined to zero by 96 h. SBCs showing ‐SH staining increased to a maximum of 41–59% at 24–48 h and declined to 26–45% by 72 h, whereas S‐S‐stained SBCs were only a few at 8–24 h and then increased up to 65–85% by 72 h. The results seem to indicate that S‐S linkage may occur in the pr

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb07651.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYSerum γ‐glutamyl transferase was elevated fourfold in all thirty‐four new cases of porphyria cutanea tarda. Phlebotomy treatment decreased it. The twelve patients in relapse showed a considerable increase, while those in remission tended to a gradual elevation in the enzyme over the course of years. γ‐Glutamyl transferase is a useful auxiliary parameter in porphyria cutanea tarda particularly in untreate

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb07652.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYAntihistamines are commonly used in the treatment of urticaria. Some antihistamines contain dyes and preservatives which have themselves been shown to produce or exacerbate urticaria; the presence of these substances is not indicated in the usual formularies and a list of commonly prescribed antihistamines is presented, detailing the azo dyes, other dyes and preservatives contained therein.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb07653.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYForty otherwise healthy patients over 50 years of age with early, severe painful herpes zoster were randomly allocated to two groups for treatment. Twenty patients received prednisolone 40 mg daily with gradual reduction over a period of 4 weeks, whilst the other twenty patients received carbamazepine 100 mg four times daily. Thirteen of the twenty patients (65%) in the carbamazepine treated group developed post‐herpetic neuralgia lasting up to 2 years, whilst only three of the twenty prednisolone treated patients (15%) had post‐herpetic neuralgia lasting up to 6 months only. Thus the incidence and duration of post‐herpetic neuralgia were considerably reduced in the prednisolone treated group. In neither group did disseminated zoster or other complications

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb07654.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYMethotrexate depresses motility of neutrophils in chamber membranes, but does not interfere with random motility in tubes. Hydroxyurea has no such effect. The therapeutic response to methotrexate in psoriasis may be due in part to a reduction in migration of neutrophils into the epidermis.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb07655.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY