摘要:

SUMMARYSeven3H‐TdR‐labelled early psoriatic lesions were quantitatively evaluated after serial sectioning and autoradiography. Epidermal thickness was measured planimetrically, whereas labelled cells as well as the number of nuclei present in the dermis were counted.Marked differences in the number of labelled cells as well as in their grain density were observed. These differences correlated with the density of the dermal infiltrate. It is concluded that psoriatic epidermal hyperplasia possibly develops as a response to antecedent and persisting events in the der

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb02986.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYSerum, red cell and squame folate content have been measured in fifty cases of psoriasis with extensive lesions. Reduced serum and red cell folate have been found in 44% of the patients. Folic acid absorption, studied in twenty‐six patients, was impaired in four and significantly increased in all the others.Squame folate content has been found too low to explain the folate deficiency. Malabsorption is a possible hypothesis but it occurs too rarely (four cases). The most likely explanation of folate deficiency seems to be an increased utilization of folate by the skin epidermal cells as a result of the rapid turnover rate.The increased absorption found in most cases investigated could be a compensatory mechanism to equilibrate folate balanc

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb02987.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYAcute administration of MTX suppresses dihydrofolatercductase (DHFR) activity in skin and liver for 8 h, but there is later a reactive increase. Chronic administration is accompanied by increased DHFR, and little tissue storage of MTX‐at least in liver and kidneys. Partial hepatectomy normally stimulates DNA synthesis as regrowth occurs. Simultaneous MTX administration lowers the DHFR response, but increases that of thymidine kinase and of thymidylate synthetase. There is also reduction of deoxyuridine incorporation into hepatic DNA. These results are discussed with reference to the chemistry and treatment of psoriasi

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb02988.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYSix photosensitive patients are described, who also showed skin sensitivity to white fluorescent lamps. The results of tests with monochromatic irradiation showed that all patients were very sensitive to the ‘sunburn’ part of the spectrum (300–320 nm) with a lowered minimal erythema dose and a delayed papular‐type reaction.Tests with a number of cut‐off glass filters demonstrated that the fluorescent lamp sensitivity in these patients was due to the small amount of ‘sunburn’ UVR emitted. Spectral power analysis of the lamps showed that, with the exposures used in our tests, sufficient 300–320 nm UVR is emitted to produce skin reactions in very se

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb02989.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYThe effects of long ultraviolet radiation (UVA) on the fluorescence of twenty‐four photosensitizing and related compounds were studied. Each compound was applied in two areas on the skin of hairless mice. One area was irradiated. The fluorescence in both areas was then inspected every day until it disappeared.Persistence and change of colour of the fluorescence as a direct immediate effect of UVA radiation on compounds having photoallergic potential, i.e. salicylanilide, halogenated salicylanilide and phenothiazine derivatives, was observed. Compounds known for their phototoxic effects, i.e. acridine dyes, did not show such changes after irradiation, while 8‐methoxypsoralen showed persistence of fluorescence without change of col

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb02990.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYThe effects of long wave ultraviolet radiation (320–400 nm) on the binding of twenty‐five fluorescent photosensitizing and related compounds to the major saline soluble guinea‐pig epidermal proteins were studied. Binding before or after irradiation was detected on polyacrylamide disc gel electrophoresis by correlating the fluorescent migration pattern with the amido black counterstained pattern. Effects were seen only on photo‐allergic and structurally related compounds (phenothiazines and halogenated salicylanilides). The binding of five phenothiazine derivatives was detected only after irradiation. Ten of twelve halogenated salicylanilides were bound without irradiation, and eleven were bound following it. Ultraviolet exposure appeared to increase the amount of each halogenated salicylanilide that was bound and/or to alter the existing

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb02991.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYThe impedance of human skin was measured at a frequency of 25 Hz and 0.032 mA before, during and after exposing 6 cm2skin for 60–240 min to 10 or 12 ml of alkali (NaOH and sodium phosphate) and sodium chloride solutions, adjusted to different pHs. From the impedance and phase angle values, measured at intervals of 10–60 min between different pairs of skin sites, the changes in the single transition resistances of these skin sites were calculated.Sodium hydroxide (NaOH) solution at pH 12.0, within 10 to 15 min, abolished skin resistance completely; a solution of sodium phosphate, adjusted to the same pH, affected skin resistance similarly, but only after 60 minutes.The order of severity in skin effects of solutions of other alkaline substances, adjusted to different pHs was determi

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb02992.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYThe effect of progressive extension on the structure of human skin has been studied by scanning electron microscopy. Varying degrees of strain were imposed on abdominal skin specimens by a carefully controlled mechanical testing technique. Progressive straining has a two‐stage effect on the epidermis: initial extension pulls it into a flat layer, and further extension elongates the cells. The dermal fibres reorientate, straighten, become aligned and compacted, in response to increasing strain. The onset of these changes varies through the thickness of the dermis. The efFects of strain on hair follicles, glands and fat cells are described. The structural deformations are related to the mechanical behaviour of the skin, and clinical implications of the findings are discusse

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb02993.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYThe microbial skin flora in a group of ninety‐eight adults with diabetes mellitus requiring treatment with insulin is described. As in healthy adults with a similar age range, the dominant members of the flora are the micrococci and diphtheroids.Sarcinaspecies andMicrococcusBaird‐Parker Group 7 were more common than in the general population, and there was a higher incidence of erythrasma and increased carriage of fluorescent diphthero

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb02994.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYAn investigation into the incidence and distribution of‘ecroparasites'in the close personal environment of patients with chronic unexplained dermatoses is described. Acari were found in 356 samples from 124 of 253 (50%) patients investigated. The house dust miteDermatophagoides pteronyssinusand related species accounted for 157 (44%) of the ‘parasites’ identified. The clinical and laboratory parasite recovery techniques are described and their limitations considered. The possible significance of the results is discussed and the need for further work empha

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb02995.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY