摘要:

SUMMARYTwo new cases of acute meyloid leukaemia occurring after razoxane therapy are recorded and further haematological and cytogenetic details of two cases previously reported are described. The need for long‐term follow‐up after patients discontinue razoxane therapy is emphasi

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1985.tb02054.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

SUMMARYA distinctive form of epidermolysis bullosa is reported among several members of a large Sudanese family. Although on ultrastructural grounds this appears to be simplex type, it is inherited as an autosomal recessive trait and is associated with a high mortality.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1985.tb02055.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

SUMMARYThe dermal collagen of a patient with lipoid proteinosis was investigated by immunohistochemistry and biochemical analysis. The affected skin was found to contain significantly less collagen per unit dry weight than normal dermis but showed elevated levels of type 3 collagen with respect to type 1. Purification of collagen types from affected skin after pepsin digestion showed no novel forms, but a doubling in the yield of type 5 collagen. These results correlated well with those of immunohistochemistry which showed a patchy, diffuse, widely distributed type 3 collagen and an increase in types 4 and 5 collagens associated with ‘onion skin’ endothelial basement membrane thickening. Estimation of collagen cross‐links showed an abnormal pattern with a preponderance of the keto‐imine form not normally associated with skin. These results strongly suggest that lipoid proteinosis involves a primary perturbation of collagen met

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1985.tb02056.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

SUMMARYWe studied the association between vitiligo and diabetes mellitus, and found that vitiligo is associated with insulin‐dependent diabetes but not with non‐insulin‐dependent diabetes. This gives further weight to the theory that vitiligo is an autoimmune di

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1985.tb02057.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

SUMMARYFour men with long‐standing chronic actinic dermatitis were treated with a modified PUVA regime which initially included generalized applications of topical steroids given immediately after PUVA exposure. All patients are now free of rash, no longer need protection from UV radiation, and are being maintained on twice monthly PUVA therapy (10 J/cm2

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1985.tb02058.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

SUMMARYIn a pilot study, 26 hirsute females were treated with medroxyprogesterone acetate (MPA). We used an ointment containing 0.2% MPA in 13 patients, subcutaneous injection of MPA into the hairy areas of the face in five patients and intramuscular injection of low doses of MPA in 13 patients, each for an average duration of 16 weeks. The best clinical result was achieved by subcutaneous injection, the next most successful was the intramuscular injection, and the least successful was the topical application. Hair diameter measurements, carried out in 12 patients, were found to be reduced by 33% on average. Serum androgen levels, measured monthly, remained unaffected by topical treatment, but were decreased by intralesional and intramuscular injection. The clinical improvement with topical therapy despite the lack of effect on serum androgen levels supports the idea that MPA works partly at the cellular level. The intralesional and systemic injection of MPA may exert an effect both by systemic androgen suppression and a local action.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1985.tb02059.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

SUMMARYTotal body mole counts have been performed on 432 normal healthy Caucasian subjects aged 4 days to 96 years (204 males and 228 females). The mean total body mole count in the first decade of life is three for females and two for males, rising rapidly in the second decade to a mean of 23 for females and 18 for males. In the third decade numbers are highest, with a mean of 33 for females and 22 for males. Thereafter, numbers of moles slowly drop until in the eighth decade they have fallen to levels similar to those seen in pre‐pubertal children. There is a significant association between the presence of naevi in early childhood (prior to 5 years of age) and the development in later life of large numbers of moles. In women there is no significant association between total mole counts and either parity or use of the oral contraceptiv

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1985.tb02060.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

SUMMARYThe distribution of Leu‐7 antigen was investigated using immunoperoxidase staining technique. It was found that HNK‐I monoclonal antibody reacted with peripheral nerves and sweat glands (both apocrine and eccrine) of the skin. HNK‐I antibody is a new marker for them, and may help to elucidate the nature of some skin tu

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1985.tb02061.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

SUMMARYIntradermal testing with the staphylococcal cell wall component, protein A, in healthy volunteers and in patients with atopic dermatitis and psoriasis produced a range of responses but in all groups there was an immediate weal and flare response. There was marked individual variation in subsequent erythema, but the patients with atopic dermatitis had less erythema at 15 min and 24h than normal or psoriatic individuals. The greatest erythematous reaction at 48h was seen in patients with psoriasis.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1985.tb02062.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

SUMMARYMitotic counts have been determined in the symptomless skin of nine psoriatic patients and nine healthy controls 48h after pressure‐tape stripping. A significantly increased response was seen in the symptomless psoriatic epidermis compared with the control

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1985.tb02063.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY