摘要:

Summary.—Tests of immune function over a 12‐month period in a young woman and a young man with life‐long atopic dermatitis showed depressed cell‐mediated immunity (CMI) (delayed‐type skin test unresponsiveness, inability to be sensitized to DNCB, diminished responsiveness of cultured lymphocytes to phytohaemagglutinin, enlarged subcutaneous lymph nodes without any cell‐mediated immunopathology, but with the structure of a node involved in humoral antibody production). Direct immunofluorescence localized IgE in the germinal centres of these subcutaneous lymph nodes. No anti‐immunoglobulin or anti‐C3complement fluorescent conjugates were localized in their involved or uninvolved skin. Cells corresponding to small‐and medium‐sized lymphocytes in concentrated peripheral leucocyte smears stained with FITC antiserum to human IgE. The woman's lymphocyte transformation suppression improved during a remission and relapsed during an exacerbatio

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb05045.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—The clinical and histopathological features of 15 cases with “lymphomatoid” pityriasis lichenoides are described. The eruption was characterized by the continuous formation of papules which involuted spontaneously to leave scars. The papules closely resembled those found in typical pityriasis lichenoides acuta or chronica, but in some cases larger ulceronecrotic lesions also occurred. The disease had often persisted for many years without evidence of systemic involvement. In 1 male, however, the outcome was fatal after an interval of 16 years. The spectrum of histopathological findings varied considerably from a benign‐looking infiltrate, usually in the smaller papules, to those which suggested a highly malignant infiltrate because of the presence of numerous large atypical cells. Preliminary histochemical investigations suggest that the large cells are derived from histiocytes and are distinct from leukaemic blast cells or Hodgkin's gian

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb05046.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—Biopsies of clinically normal skin and erythematous and recent vesicular lesions of 3 patients with dermatitis herpetiformis (DH) were studied by electron microscopy.The early events at the dermo–epidermal junctional zone were the presence of glycogen and lipid particles in the basal cells, rarefaction of half‐desmosomes, and small duplications of the basal lamina.In some areas of the dermo‐epidermal junction of the erythematous skin separation between epithelial basal cells and basal lamina was observed. In the vesicles fibrin, with its typical cross‐banding pattern, was seen.The early changes observed in the epithelial germinative cells were interpreted as evidence of disturbance in dermo‐epidermal interaction, possibly caused by immunoglobulin deposition at this level. The abnormal synthesis of half‐desmosomes by the basal cells could be the cause of supra‐lamin

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb05047.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—The technique of Sellotape stripping was used to investigate the role of the stratum corneum in modifying sebum excretion rate and skin surface lipid composition.All experiments were performed on the forehead. The stratum corneum influences the rate of sebum excretion as Sellotape stripping produced a significant increase in sebum excretion rate, but this effect was abolished by systemic antibiotics.Skin surface lipid composition, when sampled by absorbent papers, was not influenced by Sellotape stripping, but when sampled by an ether‐soaked sponge after Sellotape stripping, had a lessened epidermal lipid contribution. Thus the stratum corneum modifies skin surface lipid composition when sampled by an organic solvent.Absorbent papers may be preferable to other sampling techniques on the forehead in the investigation of the role of sebaceous biochemical factors in the pathogenesis of acne vulga

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb05048.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—The responses of mouse skin to single (10%) and repeated (1% or 2·5%) applications of sodium lauryl sulphate (SLS), cetrimide and Tween‐80 were examined visually and histologically after various periods of exposure. Whereas no damage was caused by Tween‐80 when given as single applications or daily for 9 days, SLS and cetrimide both produced damage. After single applications the changes consisted of epidermal cell degeneration, focal necrosis and dermal inflammatory cell infiltration. After repeated treatment acanthosis and hyperkeratosis were identified, and nuclear debris was present in the keratin layer. Cetrimide‐treated skins were more severely damaged than those treated with SLS. In general, histological changes preceded visual changes by 1 to 2 days.Irritancy due to these surfactants was related to theri physico‐chemical properties. Since Tween‐80 at the concentrations used was highly surface active and lipophilic, these properties were not considered of importance in explaining the damage due to SLS or centrimide. Both of these agents react well with protein such as keratin whereas Tween‐80 does not. Thus it would seem that this property is of primary importance in the produc

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb05049.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—Three case of unilateral idiopathic hyperhidrosis are described. Two of the lesions were congenital; the thrid occurred in later life. Quantitative sweat collections demonstrated that the sweat glands in the lesion were hyperresponsive to those stimuli, which normally evoked sweating in the skin sites where the lesions occurred. Hyper‐responsiveness of the sweat glands to cholinergic stimuli was also demonstrated, and histology revealed greatly enalrged glands.These results suggest that the hyperhidrosis is due to Increased glandular mass, although sweat gland hypersensitivity could notberuled out as an additional contributing factor to the hyperhidrosis.Local anticholinergic therapy was found to besuccessful in the treatment of all 3 patie

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb05050.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—A study of normal hair shafts by scanning electron microscopy shows that there is a regular and progressive loss of the normal cuticular scale pattern from root to tip. Appearances found in pathological conditions should be interpreted in the light of this normal variatio

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb05051.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—Intracellular distribution of the tyrosinase inhibitor in malignant melanoma cells has been investigated in order to elucidate the defect of melanization in the pigment cell cytoplasm and premelanosomes of amelanotic melanoma. We have found that the tyrosinase inhibitor has its highest activity in the cytoplasmic soluble fraction for both amelanotic and melanotic melanomata. However, inhibitor assay of melanoma subfractions reveals a distinct difference between the inhibitor activity of amelanotic and melanotic melanomata. Premelanosome‐containing subfractions of amelanotic melanomata contain much higher inhibitor activity than those of melanotic malignant melanomata. A high concentration of inhibitor seen in subfraction 3 which contains most of the total succinoxidase activity is found to be contained in the premelanosomes of this subfraction.It is suggested that the absence of melanization in the non‐premelanosomal cytoplasm of pigment cells and in the premelanosomes of tyrosinase containing amelanotic melanomata is directly related to the concentration of tyrosinase inhibitor in these compartments of the

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb05052.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—Thirty‐two human malignant melanomata have been investigated with the electron microscope. On the basis of the fine structure of the melano‐mata and melanosomes we have distinguished 2 different tumour forms (Type A and Type B). The melanosomes of Type A appear cigar‐shaped, whereas the premelanosomes have an internal helical structure exhibiting periodicity. Most of the mitochondria of this tumour type show an elongated from and numerous cristae. The nucleolus is usually very large and exhibits some vacuole‐like structures which contain a fine granular substance. The nucleus is distinguished by the different extent of heteropyknotic chromatin and fre‐quently has “nuclear bodies”. The tumour cells of the other melanoma form (Type B) contain only spherical melanosomes, whereas the premelanosomes show no internal fibrillar structure. The mitochondria mostly appear spherical as well; their matrix is slightly electron dense. There is no marked difference between the nuclei of these 2 melanoma forms. Their pathogenes

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb05053.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—Two essentially similar cases of extensive basal cell epitheliomata of the face are reported, which had been treated with x‐rays without a definite cure and were treated by us with 5‐fluorouracil ointment until the epithelioma was totally destroyed. This was followed by free transplantation of a split skin flap with primary healing and an excellent cosmetic result. The method offers an alternative treatment for extensive basal‐cell epitheliomata which are not cured by radiotherapy and operative m

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb05054.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY