摘要:

Summary.—Psoriasis of the finger nail produces metaplastic change of the nail matrix and nail bed to skin‐like epithelium, following which the histological changes are essentially similar to those seen in the skin. The resulting lesions of the finger nail are of 2 types: (1) Nail plate abnormalities, the nature of which depends upon the site and the duration of disease in the matrix; (2) Nail bed abnormalities, consisting of onycholysis, subungual keratosis and splinter haemorrha

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb05069.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—Four cases of toxic epidermal necrolysis, confirmed by skin biopsy, are described. The first case was due to allopurinol. The second case was caused by a pyrazolone derivative in a patient who, 15 days previously, had developed an urticarial exanthem from tetanus antitoxin. In these 2 fatal cases Stevens–Johnson syndrome coexisted. In the remaining cases toxic epidermal necrolysis occurred alone and recovery was unevent

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb05070.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—In a patient with allergic contact dermatitis from pyrethrum (Chrysanthemumspp., family Compositae), pyrethrosin produced strong, and pyrethrin II weak, positive patch test responses.Some other compounds derived from pyrethrum, viz. chrysanthemumic acid, the ethyl ester of this acid and its naturally occurring insecticidal esters, pyrethrin I, cinerin I and II, jasmolin I and II, and the synthetic ester allethrin and chrysanthemin, taraxasterol (pyrethrol) and tiglic acid produced negative patch test responses.In this patient, pyrethrosin, a sesquiterpene lactone which does not have insecticidal properties, was the principal allergenic fraction of pyrethrum derived from species ofChrysanthemum. Of the 8 esters of chrysanthemumic acid which were tested, pyrethrin II was also allergenic in this cas

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb05071.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—To test the hypothesis that patients with atopic dermatitis would react with a scratch response to a variety of environmental signals a group of 18 patients and a group of normal controls, matched for age and sex, took part in a conditioning experiment with an itch as the unconditioned stimulus (U.C.S.). The dermatological patients were found to differ from the controls in terms of several personality measures, notably anxiety and hostility, and in the number of galvanic skin responses and scratch responses they produced during the conditioning sessions. The implications of these findings are explored and a tentative hypothesis about the aetiology and nature of atopic dermatitis is propose

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb05072.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—In the eccrine glands of mouse footpads mitoses are common in the intradermal ducts, and they also occur in the ampullae. No mitoses were seen in either the gland cell or the intraepidermal ducts.The duct cell mitoses were not inhibited by either the epidermal or the sebaceous gland chalones. However, it was found that human sweat contains an inhibitor of eccrine duct mitosis, which does not inhibit either epidermal of an eccrine gland chalone. In support of this it was found that adrenalin inhibits and adrenalectomy promotes eccrine duct mitosi

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb05073.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—Occulusion has been shown to increase the rate of closure of superficial woulds. However, it has laos been shown to inhibit cell division both of psoriatic lesions and stripped skin. This work was undertaken to investigate further this appartent anomaly. Forur dressings—an occulsice, adhesive tape; the adhesive backing from thsi tape; a less occlusive adhesive tape; and an occulsive, non‐adhesive film, were used to cover regions of normal and stripped skin for periods from 2 to 6 days. The results show a slight increase in mitotic rate and epidermal thickness of normal skin, under all dressings. These results are discussed and it is suggested that the less occlusive films might be of benefit in accelkerating the healing of wounds without adding the risk of infection seen under complete occul

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb05074.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—Ultrastructural changes of nuclei and nucleoli were studied during the physiological maturation of human keratinocytes. Most nuclear and nucleolar changes were observed in keratinocytes of the upper cell layer of the stratum granulosum, in which these cells are transformed to horny cells. Nucleolar changes were characterized by the segregation of nucleolar ribo‐nucleoprotein components, the formation of ring shaped nucleoli and by a reduced quantity of granular components. In addition to the known nuclear ultrastructural changes in keratinocytes of the upper cell layer of the stratum granulosum, an increased number of perichromatin granules was noted in the nuclei of these cells. The number of interchromatin granules was variable.The nucleolar segregation, formation of ring‐shaped nucleoli and the decrease of nucleolar granular components in keratinocytes of the upper cell layer of the stratum granulosum, together with the increase in the number of perichromatin granules, might suggest that the RNA synthesis in these cells is inhibited first in the nucleoli before the cessation of extranucleolar RNA synthesis and nuclear disintegr

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb05075.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—The application of a continuous fluorimetric assay technique to carboxylic ester hydrolases (including the cholinesterases) in skin is described.The kinetic properties of guinea‐pig skin preparations from different anatomical sites are reported.Thein vitroandin vivoeffects of propranolol and some other pharmacological compounds on carboxylic ester hydrolases from guinea‐pig skin are described.The results are discussed in relation to

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb05076.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—The patterns of incorporation invitroof 14C‐acetate into the lipid classes of the isolated human sebaceous gland and overlying appendage‐freed epidermis have been compared with those obtained from the sebocyst (steatocystoma) and the wen (keratinous cyst of skin).The characteristic pattern of incorporation obtained from the wen resembled that of appendage‐freed epidermis, thus confirming previous histological and biochemical reports that these cysts are not of sebaceous origin.Two patterns of incorporation were obtained from the sebocysts; one closely resembled that of the isolated sebaceous gland, and one of the appendage‐freed epidermis. These biochemical findings can be directly related to previous histological studies of the

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb05077.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—Suspensions and creams containing elemental sulphur were shown to be capable of inducing comedones in the rabbit ear and on human backs.Sulphur phur compounds, sulphides, sulphites, thiosulphates and thiols were inactive in this respect. Even though sulphur was not strongly comedogenic, the thesis is presented that its daily application in the treatment of acne vulgaris might perpetuate rather than ameliorate the disease. It is argued that sulphur has a dual paradoxical role in acne; it hastens the resolution of visible papulo‐pustules while insidiously promoting the formation of new comedones from which inflammatory lesions spring, thus establishing a vicious cy

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb05078.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY