摘要:

SUMMARYA group of patients presenting with dermatological complaints but with no significant objective dermatological pathology on examination are described. Twenty‐eight patients, twelve male and sixteen female, age range 16–76 years, mean 46 years, were seen. Symptomatology was confined to three main body areas: the face‐eight patients; scalp‐nine patients; perineum‐eight patients. The complaints related to the face were burning, intense itching and hirsutes. Scalp symptoms included excessive hair loss and intense irritation. Genital symptoms included itching, excessive redness, burning and discomfort, which in three instances prevented the patient sitting.A disturbed body image (dysmorphophobia) was common and the most frequent psychological illness present was depression. Two patients were demented and in two a diagnosis of schizophrenia was made. One patient committed suicide and two patients attempted suicide. Female patients presenting with facial symptoms have a more ominous prognosis, both with regard to the risk of suicide and the development of psychosis.It is important that dermatologists recognize this common group of patients with dermatological non‐disease. Those patients who are anxiously preoccupied with their skin may be managed by superficial psychotherapy and antidepressants. Those patients who are truly deluded should be referred to a p

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb00746.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYSolid phase radioimmunoassay for measurement of autoantibodies in human sera to an epidermal protein is presented. The protein purified from normal human epidermis is inhibitory to SH‐dependent proteases and its molecular weight is about 13,000. Antibodies were detected in 139 of the 4,400 sera collected from dermatological patients. Most of the patients suffered from wide‐spread eczematous conditions. It is suggested that the antibodies are secondary to the inflammatory conditions, but they may exacerbate or delay the course of the dise

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb00747.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYMeasurements were made of the thickness of the epidermis, the dimensions of keratinocytes and of the surface areas of individual corneocytes in normal human skin from three non‐light exposed sites. The numbers of cells in the epidermis and their height decreased with age, whereas the surface area of individual corneocytes tended to increase with increasing age. The changes demonstrated may be responsible for some of the alterations noted clinically in the skin of elderly individuals.Measurement of tissue ageing is of importance both to the interpretation of the effects of diverse external stimuli and to the study of the effect of dietary and chemical manipulations on the ageing process. Many of the tests devised measure ageing in individual tissues or organ systems and ‘test batteries’ have been employed to obtain an overall assessment of ageing in the organism as a whole (Comfort, 1979). Tests that measure a complex function such as the ‘hand grip strength test’ or determine a biochemical parameter summate the effects of disease, cumulated environmental traumata and true biological ageing and cannot in themselves be used to measure the ageing process. Histometric techniques have the advantage that inspection of the tissue allows identification of the effects of disease and exclusion if the effects of ageing alone are to be considered. They have the disadvantage of any invasive technique and in addition are time consuming.Skin is an ideal organ for the investigation of age dependent changes because of its accessibility. In addition, because of its admixture of tissue types and the different functions that it subserves it is possible to obtain a broad picture of the changes due to ageing.This study attempts to define age related change in overall epidermal dimensions and in parameters of keratinocyte and corneo

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb00748.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYWe report the uptake of four labelled sugars by keratinocytes isolated from normal epidermis, psoriatic ‘uninvolved’ skin and psoriatic lesions. Our findings include the following:1The rate of uptake of all sugars by the psoriatic lesion is increased.2This abnormally high uptake diminishes dramatically during 22 h incubationin vitro.3There is a striking abnormality in the metabolism of fucose by psoriatic keratinocytes; our data suggest an increased rate of incorporation of fucose into glycoconjuga

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb00749.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYThe sugar composition of the surface of isolated human keratinocytes has been investigated using lectins. A method is described in which the FITC‐labelled lectin is displaced with competing sugar prior to measurement. This avoids errors due to aspecific binding and utilizes the minimum biological sample. Evidence is presented which indicates that little cell surface glycoconjugate is lost during the preparation of the keratinocyte suspension from human epidermal slices using the technique described here. Values for keratinocytes are similar to those reported for fibroblast lines, being much higher than those found using erythrocytes or lymphocyte

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb00750.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYThe regeneration and turnover of the surface glycoconjugates of trypsin‐prepared pig and human cultured epidermal cells have been determined using the glycoprotein precursors N‐acetyl‐D‐(I‐3H) glucosamine (3H‐NAG) and N‐(3H)‐acetyl‐D‐mannosamine (3H‐NAM). Sialic acid assays have been performed on similar unlabelled cells. The major points which emerged from this study were:1Trypsin‐damaged cell surfaces are rapidly repaired, probably by normal membrane turnover. There was a 12% regeneration of sialic acid within 2 h and total resynthesis occurred within 24 h.2The presence of an internal membrane system, part of which also demonstrates turnover, probably contributes to the speed of surface membrane repair. Some of the glycoprotein/sialic acid of this internal membrane system (30%) remains bound for a considerable length of time.3The membrane turnover maintains the cell in equilibrium so that total loss equals the synthesis of glycoprotein.4The equilibration of3H‐NAG or3H‐NAM uptake between 24 and 48 h is limited by the relative concentrations of glucose and labelled sugar in the medium at this time.53H‐NAM was a more specific marker of glycoprotein than3H‐NAG.6The results for human epidermal cells closely matched those for pig epidermal cells, indicating that pig cells can be

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb00751.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYIn order to investigate the molecular basis of substrates, and the inhibitory specificity of tyrosinase, a large series of phenolic compounds have been analysed by using a High Performance Liquid Chromatographic‐Scanning Spectrophotometric system. Depending on their chemical structure, phenolic compounds may act as substrates or as competitive inhibitors of tyrosinase. The ability to act as substrates requires the presence in the molecule of electron donor groups, while competitive inhibition on the contrary requires the presence of powerful electron acceptor groups.Certain phenolic compounds used as therapeutic agents or as food preservatives are chemically capable of acting as alternative substrates or competitive inhibitors of tyrosinasein vitro; their effect on melanocytesin vivotherefore merits investigatio

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb00752.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYTwenty patients with disabling disorders of keratinization were treated with Tigason (etretinate, Ro 10‐9359), an oral aromatic retinoid, and the clinical responses and the effects on the skin were monitored. Most patients showed a considerable clinical improvement within 4 weeks. Side effects, such as cheilitis, were common but mostly transient or minor. In the skin there was a decrease in glucose‐6‐phosphate dehydrogenase activity within the granular cell layer of the epidermis, and an increase in mean epidermal thickness and mean corneocyte area. However, there was little apparent effect on epidermal proliferation or on histological and ultrastructural appearances. These findings suggest that the drug acts at a late stage of epidermal differenti

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb00753.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYEighteen patients with Darier's disease were treated for at least 3 months with the oral aromatic retinoid Tigason (etretinate, Ro 10‐9359). Seventeen of the 18 patients improved but adverse effects were seen in all patients, and were particularly severe in 6. No haematological or biochemical abnormalities were detected during treatment. We conclude that Tigason is an important advance in the treatment of Darier's disease but adverse effects restrict its use in some patient

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb00754.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYFollowing the initial treatment of severe psoriasis with conventional Ingram therapy, it is shown that PUVA maintenance at a mean dose‐rate of 28·6 J/cm2/month increases the average period of remission from 7 weeks to more than a year.Surprisingly, the patients who withdrew from maintenance therapy whilst still in remission have so far continued (10 months) to show an extremely low relapse ra

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb00755.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY