摘要:

SUMMARYA case of scleromyxoedema (lichen myxoedematosus) associated with an IgG1, type kappa paraproteinaemia is reported.Culture of bone marrow material demonstrated that this tissue synthesized monoclonal IgG (subclass γ I) with a light chain of type kappa. The culture of a biopsy specimen of the diseased skin demonstrated low‐speed IgG synthesis. It is concluded that the bone marrow and pathological skin synthesize a paraprotein with the same characteristics as that in the serum.Microchemical analysis of pathological skin demonstrated an increase in the content of neutral glycoproteins, hyaluronic acid and chondroitin sulphates as well as the presence of heparin and keratan sulphates.It could not be demonstrated that the serum of this patient contained antibody against connective tissue ground substance or other skin constituen

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07515.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYA patient with leucocytoclastic vasculitis, pyoderma gangrenosum, chronic pyelonephritis and a paraprotein of IgA type is described. The vasculitis responded favourably to dapsone therapy, while the pyoderma gangrenosum improved only when steroids were also given. During an exacerbation following withdrawal of dapsone, the serum IgG level fell early, but the β1cglobulin level remained normal. Immunofluorescence studies on a vasculitic lesion showed granular deposits of IgG and β1cthe walls of the blood vessels and a more extensive exudate of fibrin. Skin testing with bacterial antigens and patch testing to potassium iodide produced lesions which clinically, histologically and immunologically resembled the spontaneous vasculitic lesio

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07516.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYAntibodies against the cytoplasm of malignant melanoma cells have been found formerly to be circulating in our patients with primary malignant melanoma before metastases had developed. We have found now this same antibody in fifteen patients with resolving halo naevi. It disappears once resolution of the naevus is complete or after a solitary active halo naevus has been excised.However, cytoplasmic antibody has not been detected in the serum of any other patients with cutaneous pigmentary disorders: including fifty‐six with various pigmented tumours or naevi, many of them referred to us as suspected malignant melanoma; forty‐seven with vitiligo unassociated with halo naevi; and six with benign juvenile melanoma.We postulate that:1Halo naevus represents an accelerated and successful rejection phase of a pigmented mole developing malignant change.2There are at least two aetiological types of vitiligo, the common variety and another one associated specifically with halo naevus, perhaps initiated by the same immunological stimulus or its sequelae.3Juvenile (benign) melanoma is not related immunologically to malignant melan

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07517.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYA case is reported in which the diagnosis of pemphigus vulgaris was followed 4 months later by that of Addisonian pernicious anaemia. The lack of case reports of the co‐existence of pemphigus vulgaris and other autoimmune diseases, with the exception of myasthenia gravis, is discusse

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07518.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYBiopsies of skin lesions in different stages of evolution were taken from two patients with pemphigoid and studied by electron microscopy.Early cytoplasmic changes in the basal keratinocytes and supralaminar cleavage were seen. In the germinative cells of the regenerating skin of the blister floor in the older lesions, an inversion of the polarity of the Golgi apparatus was observed.The findings are discussed and compared with those observed in dermatitis herpetiformis. It is suggested that the pathomechanism of the early dermo‐epidermal cleavage may be similar in both disease

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07519.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYThe effects of intracutaneous injections of preparations of equal parts of betamethasone disodium phosphate and betamethasone acetate (Celestone Chronodose®) and triamcinolone acetonide (Kenacort‐A®) on plasma cortisol levels were studied. Significant suppression of plasma cortisol lasting from 3 to 13 days was observed with various doses of the first preparation. With triamcinolone acetonide, there was only a mild and transient suppress

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07520.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYIt is very difficult to find effective, acceptable protective agents for patients who are sensitive to long wave ultraviolet (UV) and visible radiation. It has recently been reported that oral β carotene is a useful photoprotective agent in erythropoietic protoporphyria (EPP) where sensitivity to visible light is important. The action of this drug has therefore been investigated in other diseases where sensitivity to the same part of the spectrum exists. Two patients with actinic reticuloid and three with solar urticaria, all sensitive to long wave UV and visible radiation were investigated before, during and after therapy with β carotene. Detailed monochromator tests were carried out and serum carotene and vitamin A levels determined at regular intervals. Therapy was continued from 2 to 12 months.Results showed that there was no objective or subjective evidence of improvement in any of the patients despite high serum carotene levels. Large variations in the dose of radiation required to produce a reaction were seen in all patients and it is essential to take account of this variation when assessing any photoprotective agent. It is possible that the mechanism of photosensitivity in actinic reticuloid and solar urticaria is quite different from that in EPP thus explaining the difference in the reported results of β carotene in the last disea

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07521.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYTopical application of retinoic acid (RA, 0·1 and 0·3% in a cream base) in psoriasis over 3 weeks showed that low therapeutic effect and frequent irritation limit considerably its usefulness in this disease. Of twenty treated patients, six had irritation warranting discontinuation of therapy, thirteen showed improvement, but none cleared completely. However, the therapeutic value was increased and the incidence of irritation was reduced if corticosteroids (CO) were added to RA. Of twenty‐four patients treated with RA + CO, eighteen were improved and four cleared completely. Combined treatment seemed also to be more effective than CO alone in the same vehicle.Light and electron microscopic studies after combined treatment showed reappearance of the keratohyaline, disappearance of parakeratosis and acanthosis and improvement of the dilated and fenestrated psoriatic capillaries. However, the number of tonofilaments was still decreased and some dermal changes were still pres

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07522.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYDapsone (diaminodiphenylsulphone) combined with triamcinolone, has effectively suppressed very severe generalized pustular psoriasis in one patient for over 18 months.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07523.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYA healthy man aged 34 was found by chance to present several features suggestive of ataxia telangiectasia (AT). The association between telangiectasia, recurrent infection and deficiency in IgA is discussed in relation to the findings in this patient.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07524.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY