摘要:

SUMMARYSeventy‐nine patients with acute or former reactions to penicillin were investigated by a benzyl‐penicilloyl (BPO)‐specific RAST and/or by skin tests with penicilloyl‐polylysine (PPL), benzyl‐penicillin and penicilloic acid and the results were correlated with the different clinical pictures. Positive RAST and skin test results could be found in patients with anaphylactic shock, urticaria and serum sickness‐like reaction and sometimes in a special group of exanthems, which are characterized by the existence of many different lesions at the same time, therefore called ‘polymorphic exanthems’, and often observed after high‐dosage penicillin therapy. In cases of scarlatiniform or morbilliform exanthems no positive results were found. The BPO‐specific RAST showed an overall correlation of 95·1% with skin tests using PPL. However, some patients with positive skin tests to benzylpenicillin and penicilloic acid did not have detectable circulating IgE antibodies to BPO. This emphasizes the need for including these antigens inin vitromethods.The RAST was informative even at the time of the allergic reaction or in the first 15 days afterwards and seems to be very valuable for early diagnosis of penicillin allergy especially in cases when many d

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb05156.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYMitotic and DNA synthesizing cell counts have been performed in uninvolved epidermis of twenty‐one patients with persistent palmoplantar pustulosis (PPP). There was no difference in mitotic counts and DNA synthesis in PPP compared with normal epidermis, but both were significantly lower than those found in the clinically uninvolved epidermis of patients with psoriasi

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb05157.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYThe apparent Michaelis constant (Km) for glucose‐6‐phosphate of the enzyme glucose‐6‐phosphate dehydrogenase has been measured in extracts prepared from biopsies of normal human skin and from both affected and apparently normal skin of patients with lichen planus. No differences of Km were found and starch gel electrophoresis of extracts from lichen planus lesions and normal controls showed similar patterns when stained for glucose‐6‐phosphate dehydrogenase activity. These results do not support the view that lichen planus is an inborn error of metabolism in which the structure of glucose‐6‐phosphate dehydrogenase of s

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb05158.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYThe cyclic AMP content of epidermal slices is increased by incubation with ethanol, the effect of which is dose‐dependent from 1 to 5% concentration in the incubation media.n‐Propanol and acetone are also effective at a concentration equimolar to 5% ethanol.Experimental results suggest that this effect of ethanol is due to activation of adenylate cyclase, rather than to the inactivation of cyclic AMP‐phosphodiest

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb05159.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYSerial observations on cutaneous sensation and on sweat response in hypopigmented flat patches of twenty‐nine patients with tuberculoid and five with dimorphous leprosy on dapsone therapy were studied over 2 years. Sensation was determined by routine methods, while sweat stimulation was done by intradermal injection of 0·1 ml (0·025 mg) of carbachol (carbaminoylcholine). There was significant improvement in sensation and considerable augmentation of sweat response in the final as compared to the initial tests. The difference in sweat response was statistically significant, suggesting the value of this simple procedure in assessing the progress of lepr

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb05160.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYA study was made of the cytotoxic effect of antibacterial antibody and complement reacting with bacterial antigens firmly adsorbed to epidermal cells. It is believed that this phenomenon enhances the severity of the lesions and their spread in some cases of disseminated eczema.In this first part of the study it is confirmed thatStaphylococcus aureusand micrococci are frequently present on lesions and ‘unaffected’ skin of patients with disseminated eczema. Intradermal skin tests with antigens of staphylococci and micrococci on 122 eczematous patients elicited immediate, or combined immediate and 4 h (Arthus‐like) responses, in a large proportion, but few showed uncombined 4 h responses or delayed hypersensitivity, in contrast to findings reported by others.Immunofluorescence tests on skin of thirty patients showed that IgG and IgM diffused into the epidermis, sometimes to the skin surface, of lesional skin, and more immunoglobulin was found in skin of ‘unaffected’ areas than in skin of normal healthy persons, indicating that clinically unaffected skin in patients with disseminated eczema is abnormal. IgD was present in three of eight samples of unfixed, and six of eight samples of fixed eczematous skin. Staphylococcal and micrococcal antigen was shown on the skin surface and also diffusely in the cytoplasm of cells in the dermis beneath the surface deposits, indicating percutaneous absorption. Further small amounts of antigen were adsorbed to some epidermal cells.These results show that the predisposing conditions for a cytotoxic reaction mediated by hypersensitivity to bacteria do occur. Increased growth of staphylococci and micrococci on eczematous skin would result in increased deposits of antigen. Bacterial antigens arc absorbed into the skin and bind with epidermal cells, and immunoglobulins diffuse into the epidermis. Furthermore, skin tests showed that many eczematous patients were hypersensitive to bacteria. Studies on the nature of the antibacterial antibody will be published in the succeedin

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb05161.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYThe incidence of eczema was assessed in acne patients and their first degree relatives and compared with control (non‐acne) subjects and their relatives. It was found that there was a statistically decreased incidence of endogenous eczema in the acne patients.It has been my subjective clinical impression that eczema occurs less frequently in acne patients than in subjects without acne, and that acne patients seldom give a family history of eczema. The following study was undertaken to examine this hypothesi

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb05162.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYThe present study was undertaken to compare the antitumour effects of intralesionally administeredCorynebacterium granulosum,Corynebacterium parvum, BCG and saline on a hamster melanoma. Forty‐eight golden hamsters were inoculated subcutaneously with Fortner's melanotic melanoma no. 1. Twenty‐four animals bore palpable tumours which were leftin situ. The remaining twentyfour animals bore palpable tumours which were excised. No non‐excised group animal showed primary tumour regression. In the excised group, the tumours generally recurred at the excision site in theC.parvum, BCG and saline‐treated animals. By contrast, the incidence of recurrence was significantly reduced by intralesional injections ofC.gra

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb05163.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYThree young adults are described with features of lichen verrucosus et reticularis of Kaposi (porokeratosis of Nékam). Serological evidence of toxoplasmosis (active or recent infection) was found in all three. Marked improvement on appropriate treatment occurred in the one patient who presented evidence of systemic toxoplasmosis

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb05164.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYEight accidental kidney biopsies in psoriatics were obtained together with 429 liver biopsies. None of the biopsies showed signs of renal damage. All patients had severe psoriasis, six had been treated with methotrexate for 1‐2‐6 years, receiving total dosages from 660 to 175

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb05165.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY