摘要:

SUMMARYIn a search for contact sensitivity to antioxidants we patch tested consecutive patients referred with eczematous dermatitis.Six cases of allergic contact sensitivity to nordihydroguaiaretic acid (NDGA) were observed. Three had been sensitized by one brand of cream containing 0‐1% NDGA, in three patients the source of sensitization could not be traced.In four patients we found positive patch tests to butylated hydroxyanisole and/or to butylated hydroxytoluene. In two cases the positive patch tests were relevant, since both patients remained asymptomatic when antioxidants were avoided in food. They both had acute flares of vesicular eczema on the fingers after oral administration of small amounts.Gallate esters and Vitamin E (d,1‐alpha‐tocopherol) each gave one unexplained positive patch test.The present data suggest that further search for hidden sensitizers in topical medicaments and cosmetics is warranted. A declaration of all ingredients in industrial products should be placed on the

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb04379.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYSuspensions of epidermal cells were prepared by trypsinization of rat epidermis and incubated withi‐14C‐acetate in Eagle's minimum essential medium. The incorporation of radioactivity into the total lipids of the cells was increased by the addition of serum to the medium. The pattern of incorporation into the main lipid classes was affected by the addition of serum to the medium and by alterations in the density of the cell suspensions. The incorporation of radioactivity into the total lipids increased approximately linearly over a 24‐h period of incubation and the pattern of incorporation into the phospholipids and glycolipids altered with time. However, at each time interval studied, reproducible patterns of incorporation were obtained under controlled conditions. The incorporation of radioactive acetate therefore provides the basis for a very sensitive method of lipid ana

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb04380.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYThe transepidermal water loss (TWL), photoelectric plethysmography and reflex photometry were parallelly registered on the involved hands and forearms of psoriatics. The TWL values showed a fairly good correlation with the clinical course of the disease: they increased during the active phase and decreased after return to normal. The vascular tests did not show a strict parallelism with the clinical state. On the basis of the findings, the temporal relations between epidermal and vascular factors during the different phases of the psoriatic process are discussed. The TWL can be used to predict a relapse occurring on the area investigated but not on a distant area.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb04381.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYCell culture experiments using haematoporphyrin photosensitized bovine hoof fibroblasts and longwave uv‐irradiation revealed two distinct and separable patterns of lethal photosensitization according to two different sensitization procedures:1Photosensitization of cell membranes by short exposure (5 min) of cells to haematoporphyrin.2Cytoplasmic photosensitization elicited by a 2 h exposure of cells to hacmatoporphyrin. Cellmembrane photosensitization was reversible by incubation of cells in serum which removed surface bound haematoporphyrin; cytoplasmic photosensitization was irreversible.Beta‐carotene was tested in these two systems and the following results were obtained: (i) Preincubation of bovine hoof fibroblasts in β‐carotene protects from lethal haematoporphyrin photosensitization. (2) Protection with β‐carotene is achieved against both types of photosensitization. (3) The protective effect of β‐carotene depends upon the duration of pretreatment, reaching a maximum after 7 days. (4) β‐carotene protection is maintained even after trypsinization of bovine hoof fibroblasts and withdrawal of β‐carotene from the medium for 24 h or more. (5) Haematoporphyrin sensitized bovine hoof fibroblasts show a distinct pattern of red fluorescence for each type of photosensitization. Incubation of bovine hoof fibroblasts in β‐carotene prior to haematoporphyrin photosensitization results in a pronounced reduction of red fluorescence. Some of these data indicate that β‐carotene acts, at least in cell membrane photosensitization, at the level of the cell membrane into which it ap

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb04382.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYWe have found that pretreatment of human skin with prostaglandin El significantly lowers the threshold of human skin to itching evoked by both histamine and papain. Prostaglandins may thus potentiate pruritus in inflammatory skin disease, presumably by a non‐specific effect on nerve‐endi

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb04383.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYSeven patients from four families are reported who had an inherited condition of which the main features were ankyloblepharon, ectodermal defects and cleft lip and palate. The ectodermal defects were partial or complete hair loss, absent or dystrophic nails, pointed widely spaced teeth and partial anhidrosis. Associated anomalies included lacrimal duct atresia, supernumerary nipples, syndactyly and auricular deformities. The inheritance of this abnormality was consistent with that of an autosomal dominant trait. The relationship between this and similar syndromes is discussed.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb04384.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYThe depletion of adenosine triphosphate in skin after mild thermal injury is not large enough to be accounted for by loss of oxidative respiration. Measurements of lactic acid production by skin suggest that glycolysis is less sensitive to heat damage than is oxygen uptake. It is therefore likely that glycolysis makes a large contribution to the relatively high levels of ATP persisting in heat damaged skin.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb04385.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYSuccinic dehydrogenase and cytochrome c oxidase activities of guinea‐pig ear skin were found to be less sensitive than oxygen uptake to mild heat damage. It therefore appears that the failure of oxygen uptake following thermal injury is not directly due to inactivation of the enzymes of the respiratory chai

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb04386.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYBiopsies from non‐hypertrophic and hypertrophic scars and from normal skin have been studied histochemically for activities of nicotinamide adenine dinucleotide diaphorase, lactate dehydrogenase, acid phosphatase, β‐D glucuronidase and alkaline phosphatase.The activities of all enzymes studied except alkaline phosphatase were found to be increased in hypertrophic scars as compared with non‐hypertrophic scars and norma

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb04387.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYDemodex folliculorumandD. brevisare found in different habitats in the skin: the former in the hair follicles, the latter in the sebaceous glands. Both seem minor pathogens—merely harvesting the cells of their respective habitats.D. folliculorumwas found aggregated (all stages) and plugging the follicular orifices;D. brevis, on the other hand, was usually solitary. In one case marked degeneration of the sebaceous gland, with leukocyte invasion, was associated withD. brevis.No correlations were discovered between either of these species and the gross condition of the skin. Positive samples were obtained from both mainland and island populations of Aborigines. Incidence values obtained were 66.6% for males and 80% for females; in the latter, the sample was small (5) and their ages over 34 year

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb04388.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY