摘要:

SUMMARYWe report the presence of tannic acid staining material in the intercellular spaces between adjacent endothelial cells of the high endothelial venules (HEVs) in psoriatic skin, which appears to be recognized by T8 (cytotoxic/suppressor) lymphocytes, as the presence of HEVs was found to be related to the presence of T8 lymphocytes in the epidermis. As HEVs with similar tannic acid staining material were also observed in peripheral lymph nodes, we suggest that this material may serve as a marker for HEVs recognized by the T8 lymphocyte subset. T8 + lymphocytes were found in the epidermis at 5 min and 1 h after tape‐stripping of uninvolved skin of psoriatic patients with active disease, but not until 24 h in a psoriatic patient in remission. The prior existence of HEVs in uninvolved psoriatic skin could account for the rapid egress of T8 lymphocytes from the vasculature to the epidermis in response to traum

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb02423.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYCutaneous telangiectatic vessels from two cases of unilateral dermatomal superficial telangiectasia were shown under electron microscopy to be venular capillaries with thick walls composed of multiple basement membranes. We suggest that this special capillary structure, seen in a variety of telangiectatic and disease states, should be called the ‘laminate capillary

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb02424.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYPhospholipase A2activity is raised in non‐lesional psoriatic epidermis compared with normal epidermis. It has been shown that the activity of this enzyme is controlled by an inhibitory protein the inhibitory effect of which is increased by dephosphorylation. Treatment of epidermal extracts with alkaline phosphatase reduced the phospholipase A2activity, both in normal and in lesion‐free psoriatic epidermis. Inclusion of pyrophosphate, a protein phosphatase inhibitor, in the homogenizing medium caused the activity of phospholipase A2in epidermal extracts from normal and lesion‐free epidermis to be raised to the same high level. These results are consistent with the hypothesis that the raised phospholipase A2activity in psoriatic epidermis is due to hyperphosphorylation of an endogenous inhibitor as a result of defective control of a phosphorylation/dephosphorylation mechanism. The relevance of these findings to other work is disc

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb02425.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYConfluent cultures of dermal fibroblasts from patients with progressive systemic sclerosis (PSS) and healthy controls were investigated for the synthesis of glycosaminoglycans (GAG) in response to a platelet release fraction (PRF) obtained by treatment of pooled platelets from normal individuals with adenosine 5′‐diphosphate (ADP). PRF, at concentrations of 1 to 50 μg protein/ml, produced a linear increase in GAG synthesis that was always greater in cultures of PSS fibroblasts than in cultures of normal fibroblasts (P<0·001). A partial inhibition of GAG synthesis was observed with 100 μg/ml of PRF. The increased GAG synthesis in cultures incubated with PRF was not due to ADP. These findings demonstrate a difference in response to PRF between PSS and normal fibroblasts and may reflect an increased responsiveness of PSS fibroblasts to platelet f

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb02426.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYWe have studied a new component of the elastic fibre system in the human dermis, which we call‘elastic sheet', using scanning and transmission electron microscopy. The structure is long, broad and flat with some holes, and may be the base of the elastic fibre system from which elastic fibres originat

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb02427.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYWe have investigated the occurrence, immunohistochemical profile, ultrastructural features and relationships to lymphocytes of the non‐lymphoid accessory cells in the dermal infiltrate of five patients affected by B celt lymphoma with secondary involvement of the skin. Typical nonlymphoid accessory cells were found in all cases. Most of these cells had ultrastructural features which resembled those of the poorly differentiated dendritic reticulum cells described in follicular lymphomas of the lymph nodes. The immunohistochemical findings of DRC‐1 +, C3b r+ dendritic cells often arranged in follicular‐like structures with neoplastic B cells and only few, scattered OKM1+, OKM5+ mononuclear phagocytes support the hypothesis that the vast majority of the non‐lymphoid cells observed in our cases were poorly differentiated dendritic reliculum cells.These results and previously published reports indicate that the organization of the dermal infiltrate of B cell lymphomas tends to reproduce the typical arrangement of the B zone of the lymphoid tissue, although with a lesser degree of differentiation, similar to that observed in lymph node follicular ly

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb02428.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYIt has been shown previously by an immunofluorcscence technique, that whole serum from patients who have anti‐Ro/SSA autoantibodies reacts with a component or components of the epidermis. We have now demonstrated by immunoblotting that the antigen identified in human epidermis by anti‐Ro/SSA sera is Ro/SSA antigen, and that Ro/SSA antigen is present both in adult and in neonatal epidermis. The presence of this antigen in tissues which are injured in the anti‐Ro/SSA‐associated syndromes subacute cutaneous lupus erythematosus and neonatal lupus erythematosus supports the hypothesis that anti‐Ro/SSA antibodies react with Ro/SSA antigen in the skin and are important in the initiation of tiss

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb02429.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYSkin biopsies from five healthy subjects, taken before and after UVB irradiation, were examined using immunohistological techniques for the cytokines interleukin‐1 (IL‐1) and tumour necrosis factor (TNF). Using polyclonat specific antibodies against IL‐1 and TNF, the two cytokines appeared identically located on the epidermal cell membranes of the stratum granulosum and stratum spinosum in unexposed skin. After UVB‐exposure, the staining intensity for both IL‐1/epidermal cell derived thymocyte‐activating factor (ETAF) and TNF was markedly increased, and the epidermal staining included the basal cell layer.Immunohistological investigation of tissue‐bound epidermal cytokines may be valuable in the study of

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb02430.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYThe prevalence of IgG class thyroglobulin and microsomal antibodies, estimated using a sensitive ELISA, was 48% in 115 patients with dermatitis herpetiformis, which was significantly greater than the prevalence of 16% in 107 unselectcd controls without dermatitis herpetiformis. IgA class thyroid antibodies were found in 29% of dermatitis herpetiformis patients. Overt thyroid disease had been diagnosed in six (5%) of the dermatitis herpetiformis group and a further six patients had elevated TSH levels. The presence of thyroid antibodies was not associated with particular HLA‐DR antigens. These results demonstrate the frequent occurrence of thyroid antibodies in dermatitis herpetiformis, although thyroid failure is less commonly associated with this condition. Immune response genes outside the HLA‐DR region may be involved in the immune hyper‐responsiveness seen in dermatitis herpetiformis which is reflected in the high prevalence of thyroid autoimm

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb02431.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYWe have quantified Langerhans cells (LC) in cryosections of normal human skin and lesional skin from patients with atopic eczema and psoriasis vulgaris using six different methods. The results from the different methods varied considerably and were sometimes contradictory, for example when LC numbers in psoriatic skin were compared with those in normal skin. Thus, in addition to the staining technique used and the selection of the dendritic cell type to be counted, the enumeration method used can also influence the quantitation of LC in normal and pathological skin.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb02432.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY