摘要:

SUMMARYThe distribution pattern of immunoglobulin‐ or complement‐bearing lymphocytes in healthy controls and in patients with contact dermatitis and with atopic dermatitis has been investigated. A significant predominance of IgD‐ and C3‐bearing lymphocytes was found in ten patients with contact dermatitis. In atopic dermatitis patients the number of IgE‐ and to a lesser extent of C3‐bearing lymphocytes was increased. The results indicate induction of stimulation of two distinct classes of immuno‐logically competent lymphoid cell lines, one in contact and the other in atopic dermatitis. The increased number of B‐cells in dermatitis indicates a decreased T‐cell population and suggests a deficiency or disturbance of the recirculation o

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb06687.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYThe ultrastructural features of two cases of porokeratosis of Mibelli are described. They demonstrate that the basophilic granular material in the cornoid lamella consists of whole degenerate cells with pyknotic nuclei. The dermis contains clumps of a finely fibrillar material and some collagen, and many fibroblasts show degenerative changes.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb06688.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYA technique of surface microscopy has been developed which gives good visualization of the skin, is reasonably inexpensive, is easy to use, and is readily adapted for micrometry and photography.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb06689.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYThe proliferative activity of sebaceous glands of uninvolved skin from acne patients was analysed by means of3H‐thymidine autoradiography and by planimetry. Twelve specimens of normal skin from the back (with thirty‐five glands) and two specimens from the face (with six glands) were analysed. Labelling indices and planimetric values were determined separately for the two portions within each gland: the differentiating cell pool with germinative cells and large lipid cells; and the undiffer‐entiated cell pool with multilayered cells.The germinative cells of the differentiating cell pool on the back and face of patients with acne showed a significantly greater labelling index than in control subjects. The undifferentiated cell pool, although having a higher labelling index than the differentiating cell pool, was similar both in acne patients and in controls. Planimetry confirmed that the sebaceous glands of patients are much larger than those of normal subjects. Therefore, the known increase in sebum excretion in acne patients is a result of two factors—an increase in lipid cell production and an increase in sebaceous gla

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb06690.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYUsing a surface microscope technique to measure the pilo‐sebaceous duct orificesin vivo, it has been shown that keratin hydration, as produced either by a hot bath or by polythene occlusion, decreases the pilo‐sebaceous orifice size. These changes arc reversed within 90 min. This reduction in pilo‐sebaceous duct orifice size would increase sebum outflow resistance and aggravate duct obstruction. The observations therefore help to explain the exacerbation of acne seen in humid environments, such as in the tropics, and in certain occupa

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb06691.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYUltrastructural studies have been carried out on tumours and monolayers of cells of the transplantable Harding‐Passey mouse melanoma, grown in tissue culture. Tumours were found to consist of melanin‐producing, melanin‐producing‐and‐containing and melanin‐containing cells. Melanosomal complexes found in melanin‐containing cells appeared to arise by fusion of solitary melanosomes either with each other or with lysosomes. Melanophages, previously regarded as macrophages which have migrated into the tumour, are probably altered and older melanoma cells. Melanosomal complexes contained in these cells have formed by autophagocytosis. Tissue culture studies support this view. Melanoma cells grownin vitrowere invariably found to contain melanosomal complexes as well as solitary melanosomes, and older cells in culture contained numerous melanosomal complexes.Virus‐like particles resembling immature C‐type virus particles were found in all the tumours examined and were especially abundant in cultured cells. These particles were found in the cisternae of rough endoplasmic rcticulum. The significance of these virus particles is still a matte

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb06692.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYSarcoidosis in the Bantu differs from the same condition in other populations mainly in the severity and the more destructive nature of the lesions. Localization, immune responses and treatment yield similar findings to those met with elsewhere, but necrosis within the granulomata may be prominent and deforming.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb06693.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYDibcnz (b.f)‐i,4‐oxazepme (CR), a substance known to be markedly irritant to skin, has been applied in graded quantities to the skin of volunteers as (a) dry tnaterial, and (b) when moistened with saline. The cutaneous reactions produced have been observed and these have been discussed in comparison with those produced by (u‐chloroacetophenonc (CN) and o‐chlorobenzylidenemalononitrile (CS). CR has been shown to be very potent in causing skin discomfort and pain, equivalent roughly to CN and more so than CS.The effects of CR tend to disappear rapidly following its removal but recur, at reduced intensity, when the affected area is washed, even up to 24 h later. The erythema produced by CR fades rapidly and does not recur, whereas that produced by CN and CS remains for a much longer period. Vesic‐ation could not be produced with CR, even under adverse and unrealistic conditions. CR is capable of producing acute cutaneous discomfort, apparently out of proportion to the very temporary and moderate changes observed in

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb06694.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYA review of the effects of folic acid antagonists in psoriasis has now been completed. All nineteen patients have had such therapy for at least i year and some for up to 10 years. Seventeen of these patients have had recent liver biopsies and another two were studied at post mortem. The biopsy find‐ings were analysed according to mode(s) of therapy. All three patients with cirrhosis and three of four with fibrosis had received significant amounts of oral methotrexate. Eight patients had received methotrexate only by parenteral injection and only one biopsy showed mild fibrosis. A possible ancillary factor is the severity of psoriasi

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb06695.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYThe distribution of methotrexate between tissues is a very complex process, dependent in part upon the species studied, the size of the dose and the channel of administration. The nature of the tissue and its content of dihydrofolate reductase also play a part. Elimination of methotrexate in the urine and bile indicate that renal and hepatic function are also important.The amounts of administered methotrexate taken up by the skin and liver were doubled by experi‐mental folate depletion. In contrast, folate deficiency did not significantly increase uptake by the kidneys or intestines. The skin uptake of methotrexate was increased about six‐fold by prior strip‐ping, without infiuencing the hepatic uptake. Methotrexate taken up could be partially displaced by pteridines which have affinity for dihydrofolate reductase. Methotrexate itself was most efficient, but both dihydrofolate and folic acid were more effective than leucovorin, while 5‐methyl folate had virtually no effect.These results indicate that a risk of hepatic injury is probably inseparable from the therapeutic action of methotrexate in psoriasis, even though the amount of drug reaching the liver can be reduced by using a logical parenteral s

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb06696.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY