摘要:

SUMMARYClinically normal skin from patients being treated for dermatitis herpetiformis was examined with the electron microscope.Cytoplasmic processes from the basal epidermal cells penetrated the dermis through discontinuities in the basal lamina which otherwise was normal in structure and thickness. The fibrous network of the dermis consisting of collagen, small reticular fibrils, anchoring fibrils and elastin, appeared normal.In patients receiving only dapsone, membrane‐bound‘vacuoles’were found just below the basal lamina. They contained a fibrillar material of low electron density and were often associated with cell processes or complete cells, the classification of which was difficult. It is suggested that these vacuoles may be implicated in the reaction between reticulin and immunological complexes.In two specimens, early blister formation was also seen in the dermal papillae. The basal lamina remained applied to the stratum basale and was only absent where basal cell processes projected into the blister space which contained fibrin deposits. Vesiculated structures observed in the region of the blisters are interpreted as abnormal sensory nerve endings.This evidence supports the view that disruption of the basal lamina and blister formation in dermatitis herpetiformis are secondary to an earlier rea

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07560.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYClinical and laboratory findings in a case of bullous pemphigoid developing during the course of metastatic spread of rectal adenocarcinoma are presented. In addition a transient figurate erythema occurred. The possibility of a causal relationship between bullous pemphigoid and malignant disease is discussed.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07561.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYA chronic form of tyrosinosis was diagnosed in a mentally retarded girl, aged 13. Concomitant findings were skin lesions of localized epidermolytic hyperkeratosis existing without remission from infancy. A diet low in phenylalanine and tyrosine was started to reduce the patient's blood tyrosine to a normal level. After 6 months of successful dietary control of blood tyrosine, an unexpected result was a complete remission of the skin lesions. The diet was abandoned after a total period of 14 months and the abnormality of tyrosine metabolism became immediately prominent again. Some 4 months later, the skin lesions have recurred.A possible relationship between the congenital skin disorder and the abnormal tyrosine metabolism in this case is considered.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07562.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYTwo cases of bullous and nodular lichen planus induced by ingested and topically administered native medicine are described. The high incidence of lichen planus in Africa could be due to the widespread use of herbal drugs. This could partly explain the absence of buccal mucosal lesion in lichen planus in African Negroes.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07563.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYCopper and zinc levels were estimated in serum and skin of nineteen vitiligo patients as well as in pigmented moles, seborrhoeic warts and normal skin. In seborrhoeic warts, high zinc levels were associated with excessive melanization and an abundance of ATPase+ve dendritic cells. Zinc levels were also significantly increased in pigmented moles compared with those in normal surrounding skin.In vitiligo, there was a significant reduction in serum zinc while copper levels were increased in the hyperpigmented zone surrounding the lesion. The results of copper analysis in vitiligo neither support a deficiency role for copper nor justify its use in the treatment of that disease.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07564.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYSmall skin biopsies of thirty‐nine human subjects were assayed for the qualitative and quantitative analysis of glycosaminoglycans.The following results were obtained:1Besides the presence of hyaluronic acid and dermatan sulphate, evidence has been presented for the presence of heparan sulphate.2The content of glycosaminoglycans was higher in biopsies from healthy individuals than the values reported for post‐mortem human skin.3Variation of the concentration of either hyaluronic acid or dermatan sulphate plus heparan sulphate in relation to the region of the body could not be demonstrated.4With advancing age a decrease in dermatan sulphate plus heparan sulphate could be demonstrated. However, hyaluronic acid content could not be demonstrated to correlate with

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07565.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYA marked degree of hyperproliferation and hyperplasia of the epidermis secondary to experimentally induced inflammation in the corium was induced in the flank skin of guinea pigs. The substances used to evoke a granulomatous inflammation were beryllium oxide and carrageenan. The epidermal response to this subepidermal process was studied autoradiographically and it was found that the epidermal reaction was similar to that found after direct epidermal trauma such as stripping of the horny layer. It is assumed that dermal factors are responsible for initiating this epidermal reaction and their possible nature is briefly discussed.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07566.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYGround guinea‐pig skin slices release a potent stimulant to epidermal cells which causes them to enter DNA synthesis (Hell, 1970). Further experiments have shown that this effect on the epidermis is immediate. If the stimulant‐containing medium is replaced 15 min after setting up the experiment by fresh medium containing no stimulant, the epidermal cells have already received the impetus to enter the DNA synthetic period, and the original medium is without its characteristic effect on a further set of skin sli

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07567.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYPlasma corticosteroid levels in 295 out‐patients using halogenated topical steroids were compared with levels in 158 controls. The mean level of the treated patients was 12‐5 /(g/ioo ml compared with 14 μg/100 ml in the controls; 96% of the patients who used topical steroids and 99”,) of the controls had levels of 6 μg/100 ml or more. Five of the six patients whose plasma corticosteroid levels were less than 5μg/100 ml on first sampling had normal values on retesting after an interval of 2 weeks

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07568.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYForty patients with chronic skin disease who have used potent topical corticosteroids for a prolonged period were studied to determine if adrenal axis suppression had occurred. Thirty‐seven cases (92·5%) were normal when the first test was performed and all were normal when retested. Adrenal axis suppression was therefore not of importance in this group of typical outpatients with chronic skin disease. This is an important finding to put into perspective a theoretical rather than a real complication of topical corticosteroid therapy in adul

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07569.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY