摘要:

SummaryImmunohistochemical studies were performed to establish the distribution of membrane cofactor protein (MCP; CD46), decay‐accelerating (DAF; CD55) and homologous restriction factor (HRF20; CD59), in normal skin appendages, and in benign and malignant skin neoplasms. At least two of these regulators were detected on normal eccrine glands, apocrine glands and sebaceous glands. They were also found in cellular naevi (CN), seborrhoeic keratoses (SK), basal cell carcinoma (BCC). Bowen's disease (BD), squamous cell carcinoma (SCC) and Paget's disease (PD). Although there were slight differences in their distribution, these regulators were found in all the cells examined, indicating that they are essential factors in human skin as well as other organs, and in neoplasms, in preventing autologous complement attac

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1992.tb14814.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1992.tb01234.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryThe degree of sun protection provided by various styles of hat at different anatomical sites on the head was measured using model headforms and ultraviolet‐sensitive film badges. It was found that hats with a small brim, such as the flat cap favoured by elderly male photosensitive patients, provided negligible protection at all sites apart from the vertex and forehead. Peaked baseball‐style caps offer good protection to the nose but are relatively ineffective at other sites on the face. Hats with a wide (>7.5 cm) brim are necessary in order to provide reasonable protection factors (>3) around the nose and che

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1992.tb14816.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1992.tb01213.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryWe have examined smoking habits in 108 patients with psoriasis, including some with palmoplantar distribution, and compared the results with matched controls from the community. There was a significant association between psoriasis, current smoking status(OR=2.7, 95% CI 1.44‐5.42, P<0.01) and smoking habits prior to the onset of disease(OR=3.75, 95% CI 1.68‐9.47, P<0.001). There was also a marked dose‐response relationship; the relative risk of psoriasis in those currently smoking more than 20 cigarettes/day was significantly elevated(OR=5.3, 95% CI 2.1–13.0, P<0.001). Separate analysis of patients without palmoplantar distribution of psoriasis showed a significant association with smoking prior to onset of psoriasis(OR=3.6, 95% CI 1.5–9.8, P<0.001). Smoking may play a role in the aetiology of this common skin

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1992.tb14818.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryWe have prospectively performed patch and intradermal tests on 105 consecutive patients, attending for patch testing, to determine the optimum method of screening for corticosteriod hypersensitivity. Patch tests with Pivalone® and a corticosteriod series (all 1% in ethanol) detected all the patients with steroid sensitivity. However, intradermal tests were essential to exclude false positive reactions and detect all relevant steroid allergies in any individual patient

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1992.tb14819.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryThe epidemiology and outcome of basal cell carcinoma (BCC) in adults aged 15–34 years were examined. Northern Region Cancer Registry data from 1979 to 1989 revealed a crude annual incidence of 37/100.000 total population and the incidence was constant in all age‐groups during this period: 150 patients (1–2%) were aged 15–34 years. There was a small excess of females in the young age‐group.The outcome of BCC in young adults was determied using records of all patients registered over 5 years ago and additonal information from family doctors where required. Patients with BCC in naevus sebaceous or with syndromes of which BCCs are a feature were excluded. Median duration of BCC pre‐diagnosis was 3 years. Of 39 patients with completed 5‐year follow‐up date. 21% had either incomplete excision requiring further early treatment (n=4), a later local recurrence (n=2), metastatic BCC (n=1) or a subsequent furhter primary tumour (n=1): an additional three patients had two primary tumours at initial presentation. Median hospital follow‐up was 12 months but the apparent disease‐free interval in patients with recurrent or new BCC was frequently over 2 years.BCC in young adults may not be suspected because it is uncommon. However, the high frequency of local recurrence and of mulitiple primary tumours indicates that careful follow‐up is prudent in young pati

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1992.tb14820.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1992.tb01214.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryWe report a case of purpura fulminans associated with protein S deficiency following chickenpox in an 8‐year‐old

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1992.tb14821.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryThree siblings, the children of a marriage between first cousins, are reported with the characteristic only eight reported cases of this disorder, and it has not previously been described in Great Britain.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1992.tb14822.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY