摘要:

SUMMARYThe amount of dermal collagen is increased in systemic sclerosis. However, unlike certain inflammatory conditions, the relative proportions of Type I and Type III collagens are closely similar to those found in normal adult dermis. Similarly, no change in the distribution of the collagen types could be detected by immunofluorescent staining, although a considerable thickening of the epidermis was clearly evident in all the sclerotic lesions examined.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1979.tb01635.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

SUMMARYSixteen patients had biopsy‐proved inflammatory sclerosis of the panniculus or fascia, which usually was seen in a generalized distribution. Although the sclerosis involved the digits of five patients, it was the result of centrifugal spread of the sclerosis and was not accompanied by ulcers, calcinosis, distal phalangeal resorption or telangiectasia. Four patients may have had digital vasopasm in the extremities involved in the sclerotic process. Five patients also had cutaneous lesions of dermal morphoea or lichen sclerosus et atrophicus. Four patients had a reduced carbon monoxide diffusing capacity, and one of these had roentgenographic evidence of pulmonary fibrosis. In three patients, oesophageal motility or barium swallow studies showed evidence of sclerodermatous changes. The sclerotic process was a contributory cause of the death of one patient. Five patients had peripheral eosinophilia. Six patients seemed to have responded to anti‐inflammatory agents.We believe that subcutaneous morphoea is generally more inflammatory than generalized morphoea of the dermal type and may be more likely to progress to mild systemic sclerosis. We suggest that response of subcutaneous morphoea to anti‐inflammatory agents is simply a reflection of the degree of inflammation pr

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1979.tb01636.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

SUMMARYA 53‐year‐old woman developed swelling of her hands after strenuous sport. Soon her feet became affected and the swelling spread up the arms and legs making arm movement and walking difficult. No Raynaud's phenomenon appeared or other features of systemic sclerosis. There was eosinophilia and hypergammaglobulinaemia in the peripheral blood. Histological examination of the skin showed an increase in the collagen bundles in the dermis extending down to the adipose tissue. The fascia showed dense fibrous tissue with a perivascular infiltrate of lymphocytes, a few plasma cells and eosinophils. Immunohistology of the skin and fascia were negative for IgA, IgG, IgM, C3, CIq and fibrin. After 4 weeks of prednisolone 40 mg daily there was a great improvement. This continued with further corticosteroid ther

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1979.tb01637.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

SUMMARYThein vitroendotoxin‐induced fibrin microclots could be completely inhibited in blood by treating the patient with an oral dose of 30–60 mg prednisone 24 h before drawing the blood sample. When added to 100 ml bloodin vitro, the minimal inhibiting dose of corticosteroid is 0.004 mg betamethasone or 0.5 mg hydrocortis

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1979.tb01638.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

SUMMARYEleven patients with the clinical picture of herpes gestationis were investigated. Biopsies were taken from involved and uninvolved areas of skin and the immunopathological and microscopic changes studied. Direct immunofluorescence showed a deposition of C3and/or IgG at the basement membrane zone in the involved skin of nine patients and the uninvolved skin of five. Immuno‐electron microscopy using a multistep peroxidase antiperoxidase method revealed thein vivodeposition of IgG at the basal plasma cell membrane that extended into the lamina lucida. Light microscopy of urticarial and vesicular lesions showed a marked oedema of the papillary dermis with an inflammatory cell infiltrate that was mainly perivascular. There was spongiosis of the epidermis with oedema and necrosis of the basal cells and in several specimens sub‐epidermal clefts with bulla formation. Electron microscopy confirmed the marked degenerative and necrotic changes of the basal cells in the involved areas of s

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1979.tb01639.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

SUMMARYKeratin proteins of human epidermis have been isolated from normal and abnormal tissues. The normal proteins whether removed from living layers (prekeratin) or from the stratum corneum (keratin) are shown to consist of three chains, molecular weights 65,000 (A), 60,000 (B) and 52,000 (C). When compared with the epidermal proteins isolated from abnormal tissues, differences can be detected in the electrophoretic pattern of the subunits. In general, relative amounts of the individual chains are altered and in specific cases one or two of the polypeptides found normally are missing. All the α‐fibrous proteins extracted are found to be very similar in amino acid compositi

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1979.tb01640.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

SUMMARYFive cases are reported of Noonan's syndrome, all of which presented keratosis pilaris atrophicans faciei (ulerythema ophryogenes).This dermatosis fulfils the criteria mentioned by Noonan&Ehmke (1963) as a pointer for the investigation of cardiac anomalies, especially of the pulmonary artery.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1979.tb01641.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

SUMMARYThe literature on hair casts suggests they are rare even though Kligman intimated in 1957 that in some scalp diseases they might well be common. In this study, casts have been looked for in a group of orthokeratotic and parakeratotic scalp conditions.Hair casts are indeed common in psoriasis, pityriasis amiantacea, pityriasis capitis and seborrhoeic dermatitis. No casts were seen in women with traction hair styles or in those regularly using hair sprays.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1979.tb01642.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

SUMMARYHalo naevus cells on frozen sections react with sera from patients with benign halo naevus or with malignant melanoma. Halo naevus cells also react with our specifically absorbed heterologous antihuman malignant melanoma antiserum (RAMMA). Since the cytoplasm of all the naevus cells within the halo naevus react with sera from patients with malignant melanoma, this implies that the entire population of melanocytic cells in the mole has undergone mutation, because non‐pathological skin melanocytes do not reac

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1979.tb01643.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

SUMMARYThe present study was undertaken on the hypothesis that methaemoglobin production and haemolytic anaemia following dapsone administration could be ascribed to an impairment of glucose‐6‐phosphate dehydrogenase‐enzymatic activity. Analysis of the kinetic parameters of the G‐6‐PD (Vmaxand KM) was performed in ten patients, normal with respect to G‐6‐PD, suffering from various dermatoses. It was concluded that haemolytic anaemia after dapsone therapy is not due to a functional impairment of the enzyme. The close relationship between dapsone dosage, methaemoglobin production and anaemia make reasonable the hypothesis that a toxic dapsone derivative (DDS‐NHOH) could be responsible for the methaemoglobin formation and the hae

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1979.tb01644.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY