摘要:

SUMMARY.Twenty‐five patients with pityriasis versicolor have been studied clinically and mycologically and the hospital records of a further 62 patients have been analysed. The sex ratio for the whole series was 3 males to 2 females, the age of onset was usually in the early twenties. Nearly all cases in the Cambridge area start in the warmer months of the year. Conjugal cases are reported but a genetic factor in susceptibility is also accepted. Attention is drawn to the extent of the lesions on the limbs and flexural involvement in association with excessive sweating is shown to be common.Pityrosporum orbicularewas cultured from the lesions of 25 of 27 patients and its presence was also detected on uninvolved skin. The evidence for the identity ofP. orbiculareandMalassezia furfuris reviewed briefly and the analogy is drawn with yeast/mycelium transition in candidiasis. The ecology ofP. orbiculare/M. furfurin pityriasis versicolor is discussed in the light of the results presente

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb13990.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.Three patients, all elderly men, are described with a perniotic type of skin involvement associated with an unusual blood picture with neutropenia and monocytosis. Haematological studies, including repeated marrow examination, have been suspicious of an underlying monocytic leukaemia in each case but no confirmatory evidence has been found and it is probable that these patients have a pre‐leukaemic state. The pattern of skin involvement has been reminiscent of chilblain lupus erythematosus or sarcoidosis, and has been characterized by symmetrical involvement of the backs of the fingers, the toes, the ears and nose by violaceous plaques. The suggestion is made that these patients are examples of a distinct and previously unrecognized entity. The literature concerning the cutaneous manifestations of monocytic leukaemia is briefly reviewe

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb13991.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.In a man aged 67, mycosis fungoides and neuromyopathy developed at the same time. Autopsy examination showed no metastases in the nervous system.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb13992.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.The authors performed patch tests with denture materials in patients with denture sore mouth. In the tests, the patient's own saliva was used as wetting agent. In 2 series of control tests another saliva and distilled water were used to moisten the test material. Dermatitic reactions developed regularly on those test sites moistened with the patient's own saliva, if the saliva contained yeasts.This dermatitis is clinically and histologically identical with experimental candidiasis on healthy skin.It is concluded that the use of infected saliva in such tests gives rise to false positive reactions. Denture sore mouth appears to be the result of the combination of occlusion by the denture and of yeast infection rather than of yeast infection alone.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb13993.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.Bullous phototoxic eruptions due to Nalidixic acid are recognized but very uncommon. We report details of 5 cases. Investigations for porphyria were carried out in 3 cases and were negative. Experimentally nalidixic acid did not cause photosensitivity in normal young men.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb13994.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.In dark skinned subjects, delayed or “secondary” pigmentation from ultra‐violet light may be the only clinical sign of sunburn. It results from necrobiosis limited to the outer Malpighian layer and hardly extends deeper than this even when the dose exceeds the maximum possible from a day's natural sunshine. Preceding erythema is not merely masked by the pigment, but is often virtually absent. On the background of this natural skin resistance, the hyperkeratotic pellagrous lesion is interpreted as a marked reaction to mild or repeated ultraviolet injury followed by retention and ultimate cracking of the abnormal layers so produced. These layers are formed below the normal stratum granulosum when the initial damage is severe, but lie above the new stratum granulosum which forms underneath as the cells kerat

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb13995.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.The distribution of LDH‐isoenzyme fractions in erythrocytes in psoriasis was investigated. The results indicate a shift of enzymatic activity towards the anodic isocomponents LD2and LD1and thus to enhanced energy production by oxidation in psoriatics as compared with normal controls. The authors claim that these findings support their previous reports describing metabolic deviation with enhanced glucose‐degradation through the oxidative processes of the pentose (hexosemonophosphate) cy

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb13996.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY..Phosphodiesterase activity was determined by a fluorometric method using thymidine‐5′‐3–0‐methoxy fluorescein phosphate as a substrate, in blood serum, finger‐blood, normal skin, foreskin and psoriatic skin.Higher enzyme activity was found in psoriasis both in blood‐serum and finger‐blood in comparison with normal controls. Higher enzyme activity was found in involved psoriatic skin in comparison with uninvolved skin and normal skin. The paper supports the theory that in psoriasis there are specific defects in the enzyme systems concerned with pro

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb13997.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.A method is reported for the qualitative and quantitative analysis of less than milligram quantities of sebum into its lipid components using thin‐layer absorption chromatography. The procedure has been developed to study relatively large numbers of samples, such as are collected from subjects taking part in a clinical therapeutic tria

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb13998.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.Identical twin boys with palmoplantar keratoderma were treated by total excision of the skin of one sole to the level of the plantar aponeurosis, followed by grafting. The hyperkeratosis did not recur on the treated sole, and the keratoderma of the untreated soles and of the palms disappeared. In both cases the keratoderma eventually recurred on the palms and on the untreated sole.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb13999.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY