摘要:

SUMMARYAn outbreak of ochronosis and colloid milium is described after the use of strong hydroquinone bleaching creams. These phenomena developed only after a few years, and took place when the melanocytes had overcome the bleaching influence. Sun‐exposure and thorough inunction of the cream were required for the more advanced changes. Analogous changes have been seen when the skin is exposed to certain crude fuels in individuals working in the sun, and phenolic components in the fuels are suspected. The study presented here covers the clinical, histological, histochemical, electron microscopical and pathogenetic features as seen in thirty‐five cases of hydroquinone damage to the dermis in South Afr

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb05110.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYThe basement membrane of the secretory coil of human eccrine sweat glands was studied by light and electron microscopy. With classical staining methods for the elastic system, elaunin ring fibres were observed in the basement membrane of the secretory coil. The ultrastructural study showed that elaunin fibres are formed by bundles of fibrotubules 10–12 nm in diameter surrounding aggregates of amorphous material. These fibres differ from elastic fibres which are thicker and have an amorphous material more homogeneous and abundan

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb05111.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYThe elastic tendons by which thearrector pilimuscle is inserted into the hair follicle were studied by light and electron microscopy. From the follicle to the muscle it was observed that these tendons are formed successively by oxytalan, elaunin and elastic fibres. In close contact with the smooth muscle cells, elaunin and elastic fibres were observed. The fibres penetrate the spaces between the muscle cells and are clamped by them. An explanation is advanced about the significance of this arrangement in the recovery after muscle contraction.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb05112.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYForearm skin collagen, dermal thickness and collagen density were measured in a large number of normal subjects as a standard reference for future studies. Skin collagen decreased with age and was less in the females at all ages. There is a direct relationship between skin collagen and dermal thickness but variations in collagen density in disease limit the use of dermal thickness as a guide to changes in its collagen content.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb05113.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYEpidermal ridge appearances over the palm in twenty normal newborn infants are described. No clear‐cut relationship between ridge appearance and sweating was found although gross ridge flattening was always associated with a negativeo‐phthaldialdehyde sweat t

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb05114.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYRadio‐isotope disappearance curves and autoradiography (labelled DNA precursors and labelled amino acids) have been used to estimate the minimum transit times for four regions of epidermis in mice. The post‐mitotic maturation time in the basal layer has been estimated and the results interpreted in relation to proliferation rates and epidermal organisat

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb05115.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYA group of thirty‐six patients, of whom fourteen were being treated with methotrexate, were studied in order to assess T‐lymphocyte function byin vitrotechniques.Circulating T‐lymphocytes in aliquots of blood were assessed by the rosetting technique. No differences were found in psoriatics, whether on methotrexate or not, compared with fifteen control subjects.Lymphocyte counts and lymphocyte transformation to phytohaemagglutinin (PHA) tended to be lower in the psoriatic group as a whole than in the controls, but the differences were not statistically significant. However, a significant inverse relationship was found between the extent of the skin lesions and lymphocyte transformation to PHA, i.e. the smaller the area of skin affected the higher the lymphocyte transformation. Psoriatics treated with methotrexate had fewer skin lesions and higher lymphocyte transformation to PHA than psoriatics not so treated, probably reflecting this inverse relationship. The reason why the presence of extensive psoriasis is associated with depressed lymphocyte transformation is not understood. No evidence was found that methotrexate depressed cell‐mediated immunity as judged by thesein vit

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb05116.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYVarious epidermal enzymes and cofactors were measured in patients with lichen planus and in healthy controls with the aid of Lowry's microtechniques, including enzymatic cycling. The steady‐state levels of the nicotinamide adenine dinucleotides NAD* and NADP were decreased and this was evident even in areas still free from lesions. The oxidized and reduced portions of NAD were altered indicating changed equilibria of NAD dependent dehydrogenases. Reduced NADP was more tightly controlled at the normal level which is regarded as evidence of an unaltered biosynthetic potential in this disease. In conjunction with earlier data the results indicate a preserved glycolytic and pentose shunt activity while the mitochondria display signs of dysfunctio

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb05117.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYA lichen planus‐like eruption was seen in four patients after bone marrow transplantation. The skin and mucous membrane appearance closely mimicked lichen planus. The histopathology was also very similar to lichen planus. The occurrence of a lichen planus‐like eruption (LPLE) after an immune basal cell damage related to the graft‐versus‐host reaction raised the question of the immune nature of this eruption. The correlation found between biological signs of graft‐versus‐host reaction and the outbreak or relapse of the lichen planus‐like eruption supports the hypothesis that the skin changes could be a sign of a chronic immune response against recipi

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb05118.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYClinical and pathological observations are presented on five patients with scleroderma who developed Thrombosis of a major vessel. Three died following intestinal infarction or limb gangrene and two had digit or extremity amputations. Severe intimal thickening of major arteries with thrombus formation was noted but no significant abnormality was found in the clotting activity of the blood. Histochemical studies in three cases suggested a reduction of fibrinolytic activity at the site of thrombosis in the diseased vessels. These studies support the view that the vascular system is profoundly altered in scleroderma and may play an important role in some manifestations of the disease.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb05119.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY