摘要:

SUMMARY.—The association of vitiligo with organ‐specific autoimmune disorders has been examined with particular reference to pernicious anaemia. A significantly increased incidence of gastric parietal cell antibody was found in serum of sixty‐two patients with vitiligo. There is now sufficient clinical and investigative evidence to suggest that absence of melanocytes from lesions of vitiligo results from immunological distur

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15985.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—Lowering of the mean IgM‐globulin value and elevation of the mean IgA‐globulin value were noted in a group of 21 patients with dermatitis herpetiformis. IgM levels determined before and after dapsone therapy revealed no clear evidence of a dapsone effect on this immunoglobulin. No relationship was noted between the IgM‐globulin levels and the intestinal mucosa biopsy grading. Fluctuations in the IgM values were noted and in some patients a fall in this immunoglobulin occurred during an exacerbation the disease. Immunoglobulin patterns were studied in 7 other skin diseases. The abnormalities noted in psoriasis closely paralleled those found in dermatitis herpet

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15986.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—Twenty one patients with allergic vasculitis are reported. The skin lesions appear to be distinctive; their natural history and response to systemic corticosteroids are discussed.The histology of the skin lesions, which was studied in 15 patients, shows characteristic features.Seven patients were found to have renal involvement. After 1 years follow‐up 4 had completely recovered; in the remaining 3 there was only minimal impairment of renal function, and one of these had had pre‐existing hypertension.Allergic vasculitis is a distinct clinical entity which can be distinguished from polyarteritis nodosa. This distinction is important when there is renal involvement as the prognosis of the two conditions is so diff

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15987.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—The incidence of carriage of C. albicans in 128 patients was 45% A higher incidence was observed in diabetics (62.5%) and in patients on antibiotic therapy (64%) than in controls (35%) or in patients receiving steroid therapy (31%). In all group the mouth was the blood principal source of carriage. No significant differences were shown in the blood levels of glucose, total cholesterol, unsaturated iron binding capacity or total calcium as between those patients in whom C. albicans could not be demonstrated, carriers of C. albicans and patients over disease due to the organis

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15988.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—Using neutron activation analysis, the copper content of normal skin both from cadavers and biopsy material has been investigated. Thirty seven samples were analysed and the results, given in μg/G of dry weight, were as follows: epidermis 2·23–1510 (mean 7·05); dermis 1·88–6·0 (

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15989.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—Imprints of 5 human melanomas were treated with formaldehyde and studied by fluorescence microscopy. Granular fluorescence was seen in the cytoplasm, and, in two of the melanomas, also large intranuclear fluorescent bodies. Microspectrofluorometry showed that the fluorescence of the nuclear bodies and the cytoplasm had the same excitation and emission maxima. Intranuclear bodies were also demonstrated in imprints stained with May‐Grünwald‐

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15990.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—The lesions of psoriasis produce very much less sweat on pharmacological stimulation than clincally unaffected adjacent skin. The Na+K+concentrations of this sweat are very much decreased.The sweat rate increased after the lesions were stripped, sweat Na+and K+increased, but to a lesser extent.It is concluded that there are two abnormalities of sweat gland function in the plaques of psoriasis: (i) superficial obstruction of the ducts leading to hypohidrosis, (ii) an abnormality of absorption by the duct leading to inappropriately low sweat electrolyte concentration.The absence of miliaria despite duct blockage is discussed in relationship to the hypothesis that miliaria is due to an imbalance between the capacity of the coil to secrete and the ability of the duct to absor

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15991.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—Two cases are reported with almost identical clinical appearances and with mycological findings consistent with a diagnosis of chronic hyperplastic candidiasis. On histological examination one proved to be a squamous carcinom

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15992.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—The case is reported of a linear and zosteriform warty naevus of 3 years' duration in a woman aged 30.Biopsy showed the histological features of keratosis follicularis.The relationship between circumscribed dyskeratotic lesions and Darier's disease is discusse

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15993.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15994.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY