摘要:

SUMMARYFourteen patients with recurrent blistering entirely restricted to the mouth have been observed for up to 7 years. Their average age was 52 years, and there was a predilection for females (ratio 2·5:1).Patients presented with thick‐roofed blisters and denuded, red, boggy areas of mucosa. The area of maximal involvement was the labial gingiva, and whilst the blisters would arise spontaneously, mechanical trauma was the obvious provocative factor in all patients. Gentle friction on normal looking mucosa would produce a bulla which became blood filled. Re‐epithelialization usually occurred within 1–3 weeks, with no scarring.Biopsies showed subepithelial bullae, and direct immunofluorescence was positive in the basement membrane zone of 2 of the 5 cases examined. The most striking feature was the extreme fragility of the epithelial attachment to the underlying corium, as shown by a useful clinical test with a probe. In10 patients, the condition gradually remitted and the probe test became difficult to perform. The term acquired oral non‐dystrophic epidermolysis bullosa was considered for the diagnosis, although aforme frusteof cicatricial mucous membrane pemphigoid remained an alt

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1977.tb12531.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYThe dermatological aspects of eight negro patients with hypopigmented sarcoid lesions are described. Light microscope histochemical studies in two patients did not reveal the mechanism of the hypopigmentation. However, electronmicroscopy of lesions in two patients showed melanocytes undergoing changes resembling those observed in other acquired hypopigmentary conditions. It is suggested that in these disorders, melanocytes react morphologically in a similar non‐specific manner, whatever the prime pathological proces

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1977.tb12532.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYA classification, based on growth pattern, was devised and applied to 156 basal cell carcinomas from134 patients. The tumours were divided into four main groups; (i) nodular; (2) nodular with infiltrative margin; (3) infiltrative; (4) multifocal. The infiltrative and multifocal types exhibited a high rate of recurrence following surgical excision whereas recurrence of nodular tumours was much rarer. It is therefore suggested that growth pattern should always be stated in the routine histopathological reporting of these neoplasms. Other features were studied and found to have no prognostic value. These included the various types of epithelial differentiation and such stromal factors as the degree of lymphocyte and plasma cell infiltration and the presence of amyloid or elastic fibres.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1977.tb12533.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYStriation of the metaphyseal regions of the long bones, a characteristic feature of the focal dermal hypoplasia syndrome, may be explained by functional X chromosome mosaicism. The following arguments are in favour of this hypothesis: (i) The striation of bones coincides with the zones of osteogenesis. (2) The skin lesions are distributed in a linear pattern as well. (3) The syndrome is probably inherited as an X‐linked dominant trait. Thus, the linear pattern of both skin and bone lesions could be due to random X inactivatio

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1977.tb12534.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYA Study of histocompatibility (HLA) antigens in 69patients with discoid lupus erythematosus (DLE) showed an increased incidence of HLA‐B7 and HLA‐B8 related to the age at onset and sex of the patient. Young females and males aged 15–39 years at onset were associated with HLA‐B7and females aged over 40 years with HLA‐B8. This supports previous studies concerning sex and age specific onset rates in DLE which suggested that there is more than one genotype in this disorder. Female patients with systemic lupus erythematosus (SLE) at all ages of onset showed a significant association with HLA‐B8. Female patients, with onset 15–39 years, with either SLE or DLE which has transformed to SLE, show a significant increase in HLA‐B8 compared with the females in the same age at onset group who have the discoid disease. The presence of HLA‐B8 in a young female with DLE may represent a risk factor for the development of the

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1977.tb12535.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYThree patients showing features of both lupus erythematosus and lichen planus are described together with their histological, immunofluorescence and other investigative findings. The similarities between lupus erythematosus and lichen planus are discussed and it is suggested that these may be the result of common pathophysiological pathways.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1977.tb12536.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYEpidermal DNA synthesis has been shown to be increased approximately three‐fold in hairless mice that were fed a diet deficient in essential fatty acids (EFA deficient) for 65 days, compared with animals fed a standard diet. Autoradiographic labelling indices showed a 330% increase in the EFA deficient mice over controls. The animals developed evidence of a diffuse thickening, scaling and loss of elasticity of the skin after 40 days on the EFA deficient diet. Histologically, the epidermis of the EFA deficient animals showed acanthosis, hypergranulosis, hyperkeratosis and increased intracellular epidermal spaces. Increased mitotic indices were found with Feulgen staining.This is further evidence that deficiencies of essential fatty acids are associated with disturbance of normal epidermal cell proliferation and control of keratinization.A single application of topical 0·1%. betamethasone valerate to EFA deficient mice reduced the epidermal DNA synthesis to that of normal diet mice. Ten percent linoleic acid topically over 2weeks also returned epidermal DNA synthesis to normal leve

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1977.tb12537.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1977.tb12538.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYPsoriatic epidermis has been shown to be more sensitive to the effects of methotrexate than normal epidermis. One possible explanation for this observation is more rapid active transport of methotrexate into psoriatic cells. This study compares the uptake of methotrexate by normal and psoriatic epidermis and demonstrates the influence of extracellular pH on this process. Methotrexate uptake was not found to be greater in psoriatic epidermis than normal. A possible explanation for this unexpected finding is discussed.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1977.tb12539.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYThe epidermis of rat skin was shown to be the major site of accumulation of label after the topical application of [3H]‐cortisol, [3H]‐corticosterone and [3H]‐triamcinolone acetonide. However, incubation of the skinin vitroin a way which ensured contact only between the dermal side of the skin and the steroid showed preferential accumulation of label from [3H]‐cortisol and [3H]‐corticosterone in the epidermis whereas label from [3H]‐triamcinolone acetonide appeared evenly spread in the dermis and epidermis. The affinity of corticosterone to soluble proteins in skin homogenates was greater than that of cortisol as measured by displacement binding and correspondingly glucose uptake into the skinin vitrowas inhibited for 18 h after a single application of corticosterone but was not inhibited

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1977.tb12540.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY