摘要:

Summary.—The activity of cell‐mediated immunity to tumour‐associated antigen has been studied in 12 patients with malignant melanoma, using the leucocyte migration inhibition test. Tests carried out in 10 of these patients before surgical removal of the melanoma showed significant migration inhibition in every case. In the immediate post‐operative period this inhibition was lost, and return of significant inhibition was observed in 9 of the 10 cases tested pre‐operatively and in the 2 cases for whom pre‐operative tests were not available. Return of leucocyte migration inhibition was noted between the 4th and 22nd post‐operative day. Possible mediators of this observed depression of cell‐mediated immunit

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb07440.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—A patient with severe pyoderma gangrenosum, without any other associated conditions, is reported. She was found to present 2 major abnormalities of cellular immunity, i.e. lack of lymphocyte cytotoxicity induced by phytohaemagglutinin and failure of dinitrofluorobenzene sensitization. Intra dermal reactions to tuberculin, trichophytin and candidin were negative, while intradermal injections of streptoccal antigen twice provoked large ulcers at the sites of injection. Dermonecrotic factor was present in her serum. High doses of steroids had to be given to heal her ulcer

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb07441.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—The inflammatory component of pityriasis liehenoides has been studied with special reference to (1) the role of small blood vessels in the pathogenesis of the disorder; (2) the nature of the inflammatory infiltrate. In the course of the investigtion 134 biopsy specimens were examined. Enzyme histochemistry, autoradiography and direct immunofluorescent staining were performed on several lesions, and preliminary electron‐microscopic studies were made on 2 papules. No immunoglobulins or complement could be detected around small vessels by means of direct immunofluorescent techniques. The enzyme histochemical and autoradiographic results indicated that the endothelium of small blood vessels remains viable and is not focally destroyed. Enzyme histochemical and preliminary electron‐microscopic data suggested that the inflammatory infiltrate is primarily histocytic in nature. It is concluded that there is no evidence that disease of the small blood vessels plays a significant role in initiating or perpetuating the disease process. It is further suggested that the primary event in the histogenesis of the lesion of PL may be the sudden massive release of vasoactive substances lo

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb07442.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—Ten patients with granuloma annulare were studied for evidence of carbohydrate intolerance. By traditional criteria, 2 had an abnormal glucose tolerance test. Of the remaining 8,3 had an abnormal cortisone‐glucose tolerance test. The findings indicate a higher incidence (50%) of glucose intolerance in these patients than is found in the average population. In the cortisone‐glucose tolerance test, plasma insulin response to glucose loading was significantly lower in the population of 10 patients with granuloma annulare than in a normal control group. The remaining 4 granuloma annulare patients with normal glucose values in both the standard and cortisone‐induced glucose tolerance tests were aiso evaluated by measuring plasma insulin response to glucose loading. These 4 patients, when evaluated as a group, demonstrated also a significantly lower insulin response to glucose than the control population. These results suggest a decreased pancreatic beta cell sensitivity to glucose stimulation in patients with granuloma a

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb07443.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—Six patients with corticosteroid‐induced atrophy of the skin with telangiectasia are recorded and are briefly discussed. The skin changes were produced experimentally in 3 volunteers by prolonged topical application of “Synalar forte” and studied with light and electron‐microscopy, It is suggested that the first changes in the dermal tissue occur in the ground substance, followed by those of elastic and collagen fibres. These changes are ascribed mainly to the incomplete inhibition of fibroblasts by the corti

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb07444.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—The first example of this rare disorder seen in Australia is presented. The clinical and histological pictures are distinctive, but the precise origin of the condition remains unknown. The various theories relating to aetiology are discusse

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb07445.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—A chronic and extensiveTrichophyton mentagraphytesinfection is reported in 3 Capuchin monkeys (Cebus nigrivitatus). The animals were severely debilitated from internal parasites, pneumonia and enteritis, which led to their deaths within 2 months of purchase by a zoo. Clinically there was widespread hair loss, with skin scaling and crusting. The histological picture was one of marked hyperkeratosis and peri‐folliculitis. The disease was not transmitted to 5 other healthy monkeys housed in the same enclos

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb07446.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—The presence of cAMP‐dependent protein kinase activity has been confirmed in skin homogenates. Half‐maximal stimulation was observed at about 5× 10−8mol/1 cAMP, which is very similar to figures reported for protein kinase preparations from other tissues. The apparent Kmfor ATP, however, was lower than values previously reported, and was unaltered by the presence

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb07447.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—cAMP‐dependent protein kinase activity has been measured in skin biopsies from atopic patients, psoriatic patients, and from healthy volunteers. No significant differences were observed either in the presence or absence of c

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb07448.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—Effects of cytochalasin B have been studied on organ cultures and dispersed cell cultures of adult guinea‐pig ear skin, using electron microscopy and time‐lapse cinephotomicrography. Cytochalasin B failed to inhibit epiboly at 1 ug/ml, caused slight inhibition at 2 ug/ml and total inhibition at 5 ug/ml. These concentrations did not appear to affect ruffling of membranes or internal cell movements. Some effect was demonstrated at 20 ug/ml. These concentrations, however, caused a general toxic effect on the cells. Ultrastructurally, there was possibly some reduction in the microfilament system, but this was far from dramatic. Abnormalities caused were increased numbers of Lysosomes and dilation of the endoplasmic reti

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb07449.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY