摘要:

SUMMARYIn a prospective study of thirty‐seven infants presenting with dermatitis in early infancy it was found that pruritus, a positive family history of atopy, and the age of onset of skin lesions were of little value in distinguishing atopic dermatitis from infantile seborrhoeic dermatitis. The most useful distinguishing features were the increased incidence of lesions on the forearms and shins in atopic dermatitis, and in the axillae in infantile seborrhoeic dermatitis. The onset of skin lesions solely in the napkin area favoured a diagnosis of infantile seborrhoeic dermatitis, but when more than one site was involved the distinction was less clear. Infantile seborrhoeic dermatitis carried a much better prognosis than atopic dermatitis. In thirty‐six out of thirty‐seven infants the definitive diagnosis could be made with confidence on clinical grounds by the age of 1 year, but was often difficult at first presentation in early in

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb01074.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SUMMARYTotal and antigen‐specific IgE levels using the radioallergosorbent test (RAST) were measured in a prospective study of thirty‐seven infants with dermatitis of early infancy, with the aim of distinguishing between atopic and infantile seborrhoeic dermatitis at an earlier age than is usually possible on clinical grounds. The results were correlated with the clinical diagnoses made after 1–2 years close follow‐up. They showed that a RAST screen to egg white and to milk antibodies, and to a lesser extent total IgE levels, are of value in diagnosing atopic dermatitis at an early age and distinguishing this from infantile seborrhoeic der

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb01075.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SUMMARYKeratotome slices were cut across the margins of rapidly‐spreading psoriatic plaques. Each slice was divided into eight sections and in each section we measured the percentage cells in S phase and the levels of glucose‐6‐phosphate dehydrogenase (both related to epidermal proliferation), acid phosphatase (associated with keratinization) and alkaline phosphatase (a marker for dermal capillaries).Disturbances in the epidermis extended only 2 to 4 mm into the ‘uninvolved’ skin, whereas the capillaries were metabolically abnormal for a distance of about 2 cm ahead of the advancing edge of the plaque. This implies that changes in the capillary may precede those in the epidermis during the spread of the psoriat

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb01076.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SUMMARYThe light and electron microscopic structure of pityriasis rubra pilaris (PRP) is described in five patients. Hyperkeratosis, hypergranulosis, keratotic plugs in the follicular openings, acanthosis and focal parakeratosis were observed. A moderate perivascular infiltrate was seen in the upper dermis. Electron microscopy revealed moderately activated keratinocytes, a decreased number of tonofilaments and desmosomes, enlarged intercellular spaces, parakeratosis with lipid‐like vacuoles and a large number of keratinosomes. Lymphoid cells were present in the epidermis in moderate numbers. At the dermo‐epidermal junction, the basal lamina was focally split, containing gaps.Etretinate therapy produced moderate to marked clinical improvement. The histological picture improved but the typical signs of PRP, including follicular plugging, persisted. Ultrastructurally the cellular activity and the amount of hyperkeratosis and parakeratosis decreased, while increases in keratinosomes, intercellular substance, microvilli and desmosomes were observed during treatm

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb01077.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SUMMARYThe humoral and cell‐mediated immune response to human papillomavirus typei(HPV‐i) has been studied in 162 patients carrying papillomas of various clinical types: deep plantar wart or myrmecia, common wart, flat wart, and anogenital wart. Circulating antibodies were detected by immunodiffusion and microcomplement fixation, using purified HPV‐iparticles as type‐specific antigen. A significant association between myrmecia and anti‐HPV‐iantibodies was found (39% of the cases).Cell‐mediated immunity was evaluated by a study of delayed hypersensitivity (DH). The main capsid components of HPV‐i(HPV‐iCP), consisting mostly of a polypeptide of molecular weight 54,000, were injected intradermally. In addition to the type‐specific antigens, HPV‐iCP contain other antigenic determinants shared by various types of human papillomaviruses and masked in intact viral particles. The DH tests to HPV‐iCP showed no differences between the carriers of different papilloma types, confirming the presence of common antigenic determinants. Moreover, they gave rise to an increase or to new anti‐HPV‐iantibody production mostly in myrmecia carriers (78% and 33% of the cases, respectively), and to new DH to HPV‐iCP in all groups of papilloma carriers (33% to 56%, depending on

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb01078.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SUMMARYThe mean titres of serum IgG and IgA gliadin antibodies were significantly increased in thirty‐four patients with bullous pemphigoid, and in twenty‐three patients with dermatitis herpetiformis, compared with twenty‐four healthy controls. The patients with pemphigoid also had increased IgG and IgA gliadin antibodies compared with nine patients with pemphigus. The reason for the high titres of gliadin antibodies in pemphigoid is obscure. These patients may have increased intestinal permeability (suggested by the presence ofβ‐lactoglobulin antibodies in some patients). Alternatively gliadin may somehow precipitate the autoimmune

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb01079.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SUMMARYRats injected with bleomycin over a 58‐week period developed weight loss, alopecia, hyperpigmentation, skin thickening and skin tautness when compared with saline‐injected control animals. The only significant abnormality in laboratory blood tests was an increased sedimentation rate in the bleomycin‐treated rats compared with controls. Histological examination of dorsal skin showed atrophied sebaceous glands and increased collagen fibres, with diameters ranging from 37·5 to 75 nm as compared with 72·5 to 100 nm in control animals. Chronic bleomycin exposure produces clinical, histological and ultrastructural skin changes similar to those found in human progressive systemic sclerosis (scler

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb01080.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SUMMARYThe enzyme activities of normal‐looking skin and blister fluid from a patient with recessive dystrophic epidermolysis bullosa (RDEB) were measured. Of the hydrolytic enzymes measured, both collagenase and neutral protease activities were considerably increased in the skin and blister fluid samples compared with values found in normal control skin and in blister fluid from a patient with a burn. In addition, skin from a healthy person cultured with RDEB blister fluid showed dermal‐epidermal separation. These findings suggest that collagenase and neutral protease may be involved in the formation of blisters in R

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb01081.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SUMMARYHistopathological criteria were used to classify twenty‐four patients with chronic urticaria into three groups, which were then studied to establish whether circulating immune complexes (CICs), complement activation and deposition of immunoreactants are confined to patients with urticarial vasculitis. Groupi(three patients) had classical urticarial vasculitis, and two of these patients showed hypocomplementaemia with evidence of C3 conversion and deposition of immunoreactants in lesional and uninvolved skin. Ten patients (group 2) with a dense perivascular mixed‐cellular infiltrate had normal or raised complement levels and infrequent evidence of C3 conversion. Immunoreactants were detected only in their lesional skin. Eleven patients (group 3) had only a sparse perivascular infiltrate. In this group, complement was normal and immunofluorescence was essentially negative. Cryoglobulins were detected in group I patients only. Monoclonal rheumatoid factor and C1q binding were positive in all group 1 patients, half the group 2 patients and none of the group 3 patients. This study suggests that urticaria and urticarial vasculitis form a disease continuum, and identifies a group of patients with features intermediate between urticarial vasculitis and ordinary urtica

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb01082.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SUMMARYWe Studied sweat gland distribution, density and activity in thirteen cases of granuloma annulare and ten cases of necrobiosis lipoidica, using a combination of the plastic impression and starch‐iodine methods. The pattern of sweat gland disturbance in the two diseases was entirely different. In necrobiosis lipoidica an intense and uniform hypohidrosis was detected throughout the lesion, whereas in granuloma annulare the disturbance followed the morphology of the lesion (the papular border showed complete anhidrosis, whereas the flat central part of the lesion showed only moderate hypohidrosis or normal sweating). The method assigns numerical values to the ‘relative density’ and the ‘relative activity’ of the functioning sweat glands compared with normal skin, thus permitting statistical evaluation of th

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb01083.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY