摘要:

SUMMARYDispersed cell cultures of guinea‐pig epidermis have been maintained for up to 36 days. The progress of these cultures has been studied by phase contrast microscopy, the adenosine triphosphatase reaction, and cinephotomicrography. Langerhans cells have been identified and their behaviour studied, particularly in relation to keratinocyte

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03048.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYA 5 h, semi‐occlusive human patch test repeated daily for 5 days, was modified for use in the rabbit Using this method, the relative irritancy of three cosmetic samples of known human irritancy was determined in the rabbit.In addition, attention was paid to assessment methods and a detailed histological scoring system is described as well as two methods of visual assessment. In order to compare the effectiveness of these methods, the reaction to a series of concentrations of sodium lauryl sulphate was examined.All three assessment methods gave similar results and the merits of combining histological and visual assessment are discusse

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03049.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYThe photochemistry of 3,5,3′,4′‐tetrachlorosalicylanilide has been studied in solution under carefully controlled conditions. When irradiated in a buffered solution of pH 7.4 (physiological pH), three atoms of chlorine are liberated from the molecule instead of one as suggested by earlier photochemical work. From this observation a mechanism is proposed to explain the long‐term photobiological effect of this compound in skin i.e. that of the persistent light

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03050.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYIn those photodermatoses in which the action spectrum involves wavelengths outside the short ultraviolet (i.e.>320 nm) little protection can be obtained against long UV (>320 nm) by the application of chemical light screening agents. An action spectrum involving wavelengths>320 nm is a common occurrence and may necessitate the additional provision of protection from a physical light screening agent. Such a physical agent is titanium dioxide and in a study of its use in a variety of formulations usingin vitrotechniques it was shown to be effective throughout the wavelengths 400‐700 nm. It was also shown to have a satisfactory protective capacity in those photodermatoses in which the action spectrum involves wavelength peaks 365 nm (335–395 nm) and 400 nm (370–430 nm). It also has a reasonable cosmetic acceptability provided care is taken to incorporate in the formulations colouring agents which can be varied to suit the individual pa

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03051.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYEighty skin biopsies from fifty patients with dermatitis herpetiformis (DH) have been examined for immunoglobulin deposits by direct immunofluorcscence. IgA was found in all fifty patients. However, in two patients no IgA was detected in their first biopsy, and it is stressed that if the clinical suspicion of DH is high and no IgA is found in a single biopsy, then the biopsy should be repeated.There are two distinct patterns of immunoglobuhn deposition in DH. The most common form of deposition is seen in the dermal papillae, termed the ‘papillary’ pattern. This pattern was the only one present in sixty‐seven of the seventy‐eight biopsies. A less common pattern is that of a ‘continuous’ line along the dermo‐epidermal junction. This was the only pattern of immunoglobulin deposition in nine of the seventy‐eight biopsies. In two biopsies both the papillary and continuous patterns were present.IgA was found in all seventy‐eight of the positive biopsies and was the only immunoglobulin detected in sixty‐seven biopsies, In addition to IgA, IgM was present in seven biopsies, and IgG in two biopsies. In one biopsy IgM and IgG were present with the IgA.The detection of IgA in the uninvolved skin in patients with DH is a simple test to perform, and at the present time is the most reliable way of establi

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03052.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYThree cases of contact dermatitis due to additives in animal feed substances are described occurring in animal feed workers. There were two cases of sensitivity to ethoxyquin and one to halquinol.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03053.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYTrichophyton rubrumcaused 79.2% of the cases of dermatophytosis observed in a sample of caucasoids from Philadelphia. Tinea pedis was found in 84% of the female and male patients with dermatophytosis. Tinea manuum occurred with equal frequency in both sexes whereas tinea unguium was more prevalent in females. Tinea cruris occurred almost exclusively in males. Infections of two or more anatomical sites were observed more frequently in males. The data are compared with those reported by Rosman (1966) from a similar study done in Copenhagen.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03054.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYAn electron microscopic study of a variety of skin diseases has demonstrated microtubular ‘inclusions’ in vascular cndoiheliurn in bullous pemphigoid for the first time. The ‘inclusions’ are similar to those originally reported in lupus erythematosus by Fresco (1968) and presently being detected in an increasing number and variety of pathological pr

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03055.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYPost‐inflammatory elastolysis and cutis laxa (Marshall, Heyl&Weber, 1966) is a skin disease in African infants which appears to be comparatively common in at least two countries. Destruction of elastic tissue and atrophy are preceded by urticarial or by annular erythematous‐papular lesions and result in severe disfigurement.The clinical features are intermediate between anetoderma (macular atrophy) and acquired cutis laxa, but sufficiently typical and characteristic to constitute a distinctive syndrome, which might represent an abnormal reaction to the bite of an arthro

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03056.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYA patient with localised heat urticaria is described. Tolerance of the skin to heat was produced by repeated exposure to hot water and complete symptomatic remission was accomplished.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03057.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY