摘要:

SUMMARYThe skin and oral mucosa were studied in an unselected series of carriers of X‐linked chronic granulomatous disease, a hereditary condition in which phagocytic cells display a pronounced functional defect.Three carriers had discoid lupus erythematosus (DLE)‐like skin lesions which histopathologically were consistent with DLE of the hypertrophic and profundus type. Four patients had experienced photosensitivity in childhood. Seven patients had recurrent aphthous‐like stomatitis which should be distinguished from the recurrent aphthous stomatitis seen in otherwise healthy individuals.The remarkably high incidence of DLE‐like symptoms in heterozygous carriers might be related to the presence of mixed populations of defective and normal phagocytes. The variable expression of skin symptoms may be related to uneven distribution of abnormal to normal phagocytes.Female patients with these clinical symptoms, especially the combination of DLE‐like skin lesions and aphthous‐like stomatitis, should be suspected of being carriers of chronic granulomatous disease and studies of phagocyte function in vitro should be performed, since the diagnosis of the carrier state is of utmost importance for genetic counselling before pregnancy.In order to describe in greater detail the clinicopathological findings and their frequency of expression in the skin and oral mucosa, we have undertaken a prospective study of nine unselected known carriers of X

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb08163.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYBiopsies from twenty‐three patients with malignant skin lesions and from twenty‐two patients with premalignant or benign skin lesions were stained for β2microglobulin by use of the immunoperoxidase technique. The results showed a significant loss of demonstrable surface β2microglobulin from the surface of malignant cells compared to benign, and a partial loss in the premalignant cases. This difference could prove to be a useful tool in the histological diagnosis of malignant skin lesions, and in assessing whether or not the lesion has been completely ex

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb08164.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYβ2Microglobulin, the invariable light chain of the histocompatibility antigen, has proved to be absent on the cell surface of basal cell carcinoma.In actinically damaged skin and in patients with a past history of arsenic ingestion changes can be observed on the epidermal cell membrane which can predict malignancy before cell dysregulation is visible. The epidermis in the basal cell naevus syndrome behaves in this respect as normal epidermis and the spontaneous tumour growth cannot be explained by a predisposing defect in the HLAantigens of the epidermal cell surface

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb08165.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYAn enzyme histochemical and cytochemical study of normal dermal microvasculature showed that respiratory enzymes, lipase and non‐specific esterase occurred in all vascular segments. Lysosomal enzymes were also widely distributed and acid phosphatase activity was localized in lysosomes, Golgi apparatus and small portions of endoplasmic reticulum of both endothelial cells and pericytes. Alkaline phosphatase activity, however, was confined to the arterial side and tip of the capillary loop where it occurred in vesicles along the luminal surface of the endothelium and in junctions between endothelial cells. The localization of nucleoside phosphatase activity within the endothelium varied according to substrate; with adenosine triphosphate as substrate, the reaction product occurred in vesicles distributed throughout the endothelial cells; with adenosine diphosphate it was limited to vesicles along the luminal surface; and with adenosine monophosphate, activity was mostly localized to the lateral surfaces of endothelial cell

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb08166.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYPurification of tyrosinase inhibitors of hamster melanomas was carried out using tyrosinase binding affinity column chromatography. This method enables the isolation of tyrosinase inhibitors with a 124‐fold purification index as compared to that of crude preparation after dialysation. The purified inhibitors consist of a mixture of 5000–6000 and a 310 molecular weight fraction. They also show characteristics of polypeptides which contain glycine, glutamic acid, serine, proline and alanine as main amino ac

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb08167.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYThe histological change known as individual cell shrinkage necrosis (so‐called ‘sunburn cell’ in mammalian epidermis) would seem to be suitable for quantitative morphological studies on the effect of psoralen treatment and near UV irradiation. The number of sunburn cells per unit length of epidermis versus varying doses of narrow waveband UVR, 305–375 nm, has been studied and an action spectrum constructed which had maximal activity at 320–335 nm. The implications of these findings are

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb08168.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYThe UVR absorption spectrum for skin surface lipid was measured by spectrometry. Significant absorption occurred throughout the UVR range, with a maximum at 215 nm. We estimate that the lipid normally present on forehead skin is likely to reduce transmission at 300 nm by about 10%.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb08169.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYThe lymphocytotoxicity technique at +15°C and +37°C was used to identify anti‐HLA and cold lymphocytotoxic antibodies in sera from two women with herpes gestationis. The degree of severity of the illness was different in the two cases. The more serious case (widespread cutaneous involvement, repeated fetal deaths) had a very powerful anti‐HLA‐A9+anti‐HLA‐B5antibody (titre 1/1000); the other had Icss severe skin lesions; she had an anti‐HLA‐B13antibody (titre was 1/256). Both cases had cold lymphocytotoxic

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb08170.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYFifty Caucasian females with lichen sclerosus et atrophicus were investigated to determine their HLA types. HLA‐B40 was the only antigen found to be significantly more common in these patients when compared with a control populatio

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb08171.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYPatients with lichen sclerosus and atrophicus have an increased incidence of organ specific antibodies, and these patients and their relatives have a significantly higher incidence of associated autoimmune diseases than a control population. The incidence of other auto‐immune diseases in patients with lichen sclerosus is highest when the onset is between the ages of 41 and 6o years, but is not related to the duration or site of the lesions.These findings suggest an immunological basis for the disease and indicate that the patients should be investigated and followed up to detect the existence of other auto‐immune disord

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb08172.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY