摘要:

SUMMARYSkin proteoglycan was demonstrated by an immunofluorescent technique using an antibody against bovine cartilage proteoglycan, after the cross‐reactivity of human proteoglycan with the antiserum had been confirmed. Normal skin exhibited specific fluorescence mainly in the blood vessels as well as in the subepidermal area. The clinically uninvolved skin of systemic sclerosis (SS) revealed no features different from those of normal skin. However, the vascular proteoglycan deposition of early systemic sclerosis was later replaced by deposition between the collagen fibres, which appeared to progress centrifugally in parallel to the increase in the skin sclerosis, suggesting a vascular initiation of the skin lesion. Sclerotic skin was characterized by random deposition between the collagen fibres. Immunoelectron microscopic studies suggested that the random proteoglycan deposition reflected uncontrolled local accumulation of proteoglycan in the interfibrillar matrix around irregularly arranged collagen fibril

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb03962.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SUMMARYA case of haematoporphyrin‐induced keloid is described in which immunofluorescence (IF) revealed antibodies eluted from circulating lymphoid cells directed against fibroblasts. The antibodies eluted belonged to the main Ig classes IgD and IgM and they did not bind complement in vitro. Their possible activity in stimulating fibroblasts is discusse

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb03963.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SUMMARYImmunofluorescence staining of exposed skin from patients with erythropoietic protoporphyria (EPP) with antibodies to serum amyloid P component (SAP) and to fibronectin produced striking fluorescence of abnormal vascular structures in the upper dermis. An appearance of linear fluorescence along the dermo‐epidermal junction with anti‐SAP was the result of confluent staining of papillary oxytalan fibres. Amyloid P component (AP) was localized in ultrastructural immunoperoxidase studies to the peripheral (abluminal) regions of thickened dermal vessel walls, the site of maximum concentration of an amorphous matrix containing microfibrillar structures, antibodies to SAP did not bind to leaflets of the reduplicated vascular basal lamina. The characteristic thickening and reduplication of blood vessel walls seen with the electron microscope in EPP therefore involves increased local deposition of both AP and fibronec

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb03964.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SUMMARYLichen amyloidosus (LA) and macular amyloidosis (MA) are two forms of localized cutaneous amyloidosis in which the amyloid occurs as larger and smaller deposits respectively in the papillary dermis. The histogenesis of the amyloid of these conditions is unknown. By using an indirect immunofluarescence technique we showed that LA and MA do not react with antibodies against different previously characterized amyloid fibril proteins. These results indicate that the amyloid of LA and MA is different from other known types of amyloid. Protein AP, which was demonstrated in amyloid of MA and LA, is known to be present in all forms of amyloid and is of unknown significance. Antiserum against keratin did not react with the larger homogeneous amyloid bodies, but showed a weak reaction with some small deposits. Histochemical staining failed to show keratin in any of the tissues containing LA or MA.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb03965.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SUMMARYDirect immunofluorescence was done in fifty‐one cases of pyoderma gangrenosum. Biopsy specimens were taken from the peripheral erythematous zone of the lesion. In thirty‐one cases (61%), there was positive immunofluorescence, with perivascular deposition of immune reactants being the most frequent pattern (twenty‐seven cases). These findings support a vasculitic pathogenesis of pyoderma gangre

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb03966.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SUMMARYInterferon (IFN) (at least 16 units/ml) was demonstrated in suction blister fluid obtained from lesional skin in nine of thirteen patients with psoriasis vulgaris and in two patients with allergic contact dermatitis, but not in blister fluid from unaffected skin. IFN was detected in only three of the sera from the patients with psoriasis. The difference in results between the blister fluid and the sera from these patients was statistically significant (P<0·025). Evidence was obtained which indicated that the activity was probably IFN‐γ (immune IFN), but the additional presence of IFN‐α in some of the fluids could not be excluded. The data indicate that IFN is produced locally in the psoriatic lesions, most likely by activated T lymph

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb03967.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SUMMARYPlasma zinc, serum albumin and alkaline phosphatase (a zinc‐dependent enzyme) were measured in thirty‐five psoriatics and their age and sex‐matched controls. No significant difference was seen between these two groups as a whole, but psoriatics with less than 1% surface involvement had significantly higher mean plasma zinc levels than their respective control group. Psoriatic patients also showed a relationship between the extent of surface involvement and the plasma zinc level, those with more extensive involvement having lower levels than those with minimal involvement.The differences were not due to disturbances in serum albumin, and no abnormalities in serum alkaline phosphatase were obs

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb03968.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SUMMARYThe irritant reaction to dithranol on normal forearm skin of forty psoriatics and forty controls was investigated by skin contact thermometry and ID 50 values were calculated for each skin type (I to IV). We concluded that there is no difference between the irritant effects of dithranol in psoriatics and normal subjects. There was no correlation between irritant dose threshold and minimal erythema dose (MED) to ultraviolet radiation (UVR) but skin type I patients are the most sensitive. The irritant response to dithranol can be partially blocked by prior treatment with indomethacin.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb03969.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SUMMARYA new method for quantifying the transparency of skin using an adapted pair of Harpenden's Calipers is described. A constant for each skinfold's ability to transmit light, the H factor, is calculated and this shows a steady decline with age.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb03970.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SUMMARYVibrissae of normal mice were measured for six cycles starting at birth. Groups of immature male albino mice were castrated at 21 days of age when E, F, G and H (Danforth nomenclature, 1925) vibrissae were in their first cycle of growth. Levels of testosterone in their peripheral plasma were reduced to about one tenth of the normal. The final length achieved by their vibrissae in all subsequent cycles was shorter than that of normal mice. Another group of immature male mice were treated with implants of testosterone propionate to give plasma levels of approximately five to ten times normal. Their vibrissae showed a significant increase in final length in all growth cycles before and after sexual maturation.Vibrissae of adult male mice treated with excess testosterone showed a significant increase in final length at the end of the growth cycle immediately after commencement of treatment. On the other hand, vibrissae of castrated adult mice showed a significant decrease in final length in the second successive cycle after castration.The rate of growth of all vibrissae remained unchanged. Changes in their final length were brought about by changes in the period of growth. Castrated mice had a slightly longer resting period.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb03971.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY