摘要:

SUMMARY.Eighty‐five attacks of Henoch‐Schönlein purpura involving 75 patients Mere witnessed. Arthritis was present in 74%, abdominal symptoms in 61%, localized oedema in 45% and renal involvement in 47%. This last may be mild, moderate or severe. When severe it may cause death in the acute phase or lead to serious permanent damage. At present it would appear that patients with quite severe diffuse changes frequently respond to high dosage corticosteroid therapy and to immunosuppressive d

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb12426.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.Five cases are reported of a distinctive bullous eruption occurring in patients with diabetes mellitus.The clinical and histological functions differentiate the condition from other bullous diseases.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb12427.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.The integumentary associations of pernicious anaemia have been studied by comparison between a group of 125 patients with pernicious anaemia and a matched control group. The significant associations of pernicious anaemia are Sutton's (halo) naevus, vitiligo (particularly of late onset), premature and early greying of hair, blonde hair and blue eyes.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb12428.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.The patterns of photo‐contact dermatitis from Jadit (4‐chloro‐2‐hydroxybenzoic acid‐N‐n butylamide) in Europe and South Australia are described and discussed. The clinical details of 11 cases reported by European authors are compared with those of 13 Australian cases, 11 of which are reported for the first time. It is noted that the average length of application before sensitization in Europe was greater than in Australia and is suggested that this difference is the result of climatic conditions. It is suggested that Jadit photo‐dermatitis is a “conventional contact dermatitis” from photo degradation products; that the drug can be retained in the skirt and thereby cause persistent light reactions; and that it can be absorbed following local application and be distributed systemically. Cross‐reactions between Jadit and several sulphanilamide derivatives which had been previously described in Europe were also found in

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb12429.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.The action spectra were determined with a high intensity light source on 11 patients (including 4 persistent light reactors) known to be photosensitive to bithionol and halogenated salicylanilides. Maximum photosensitivity observed on patch tests containing the sensitizer was in the range of 360 nm. but no reaction occurred above 420 nm. The persistent light reactors had a considerably lowered sunburn MED below 330 nm. compared with control groups. The absorption spectra of the sensitizers was determined in dimethyl formamide and in 95%, ethanol at various pH. The halogenated salicylanilides gave a maximum absorption at 282 nm. in an acid pH, but in a basic pH above 8, when phenolic ionization occurs, a second absorption peak at 360 nm. is found. Maximum fluorescence was achieved by excitation in the region of 360 nm. If the concentration of the sensitizer is equal (1%) then the order of decreasing photosensitizing ability of the tested substances was tetrachlorosalicylanilide (TCSA), bithionol. 4′,5‐dibromosalicylanilide (DBS) and 3,4′,5‐tribromosalicylanillde (TBS). Guinea‐pigs could be sensitized with TCSA within one week using combined long U.V. (320–420 nm.) and sunburn irradiation, but no sensitivity occurred with irradiation for 16 weeks using only long U.V. Patch tests on sensitized patients to photodecomposition products of TBS and DBS were negative. The possible mechanisms in the production of the persistent light reactors ar

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb12430.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.The sebum excretion rate, sebaceous count and the chemical composition of the sebum have been determined in 10 young men without or with minimal acne vulgaris and 20 young men with gross acne vulgaris. No significant relation between the sebum excretion rate and the presence of acne was found. Significant differences were found in the triglyceride and the aliphatic alcohol wax ester contents of sebum from the 2 groups. The results are discussed in relation to current ideas on the pathogenesis of acne.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb12431.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.Liver biopsy was performed in 3 patients who had previously received methotrexate treatment and in 32 patients considered for this treatment. One of the methotrexate treated patients had a granulomatous hepatitis and pronounced steatosis. The other 2 had moderate fatty infiltration. Pathological steatosis was observed in 16 of 32 patients not given methotrexate. Two of these patients had cirrhosis of the liver. Abuse of alcohol and obesity were common among patients with pathological liver findings. Fatty liver may be of special clinical significance in patients receiving hepatotoxic therapy like methotrexate.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb12432.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.Levels of the trace metals copper, manganese and zinc in skin were found to vary in the same individual from one region of the body to another. The lowest concentrations were found in plantar epidermis while the highest levels were found in the epidermis of the foreskin. It is possible that these variations are related to dendritic cell populations in these areas.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb12433.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.The presence of lactic dehydrogenase in human and mouse skin has been confirmed. Its pH curve, its inhibition by oxalic and oxalic acids, and its activity in human and mouse skin closely resemble the values reported for other preparations.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb12434.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.It has been shown previously that suppression of clinical pyogenic infection in infants as well as a reduction of the resident skin flora follows the application of hexachlorophane. In this study, the skin flora of 55 newborn babies was examined in 6 sites before and after washing the skin with soap and water and with single and repeated applications of hexachlorophane respectively. Marked suppression of the resident skin flora (diphtheroids andStaphylococcus albus) and ofStaph. aureusfollowed the use of both single and daily applications of hexachlorophane, the effect being more marked and prolonged with the repeated use of hexachlorophane. No significant effect on streptococci andE. coli was seen but an increase of proteus followed the use of hexachlorophane. No irritation of the skin or other side effects attributable to hexachlorophane were observed.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb12435.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY