摘要:

SUMMARYOf sixty‐nine examples of the photosensitivity dermatitis and actinic reticuloid syndrome, nine were found to be allergically sensitive to chrysanthemum oleoresin extract. Although this extract showed evidencein vitroof a phototoxic action we were unable within vivostudies to explain the connection between the contact allergic sensitivity and the photosensitivity. The fractions responsible for thein vitrophototoxicity appear to be different from those involved in thein vivocontact allergic sensitivity. This study provides further support for the view that in the photosensitivity dermatitis and actinic reticuloid syndrome contact allergic sensitivity is of importanc

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1979.tb15092.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

SUMMARYContact allergic sensitivity to oleoresin extract from Compositae plants was found to be usually present in individuals suffering from the photosensitivity dermatitis and actinic reticuloid syndrome. It was demonstrated in forty‐seven out of fifty‐five examples of this syndrome. These results provide support for the view that contact allergic sensitivity is an important aspect of the state of chronic photosensitivity in the middle‐aged and elderly

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1979.tb15093.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

SUMMARYWhole‐body exposure of normal subjects to erythemogenic doses of UV‐B radiation results in a decrease in the proportion of circulating E‐rosette‐forming lymphocytes, an increase in the proportion of null cells and a decreased incorporation of tridated thymidine into DNA of lymphocytes following stimulation by phytohaemagglutinin (PHA). These alterations are dose‐dependent, appear soon after exposure, reach a maximum after 8–12 h, and are reversed by 48–72 h

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1979.tb15094.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

SUMMARYThis paper is based upon a study of all available records of patients certified as having died in hospital from pemphigus and pemphigoid in England and Wales from 1962 to 1969. The results differ from most published series in that many of the 210 patients died still with extensive skin lesions and with biochemical abnormalities, such as low serum albumin, sodium and chloride, which were secondary to this. Side‐effects of treatment, such as diabetes, peptic ulceration, and infections, were also important but the commonest immediate causes of death were respiratory tract infections and pulmonary embolis

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1979.tb15095.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

SUMMARYOf twenty‐seven cases of subepidermal blistering disease of children twelve corresponded clinically, histologically and immunologically to dermatitis herpetiforms of adults, six to bullous pemphigoid, and eight to chronic Bullous disease of childhood (CBDC), i.e. IgA linear dermatosis. This latter disease seems to be a distinct entity, different from both dermatitis herpetiformis and Bullous pemphigoid, and is characterized immunopathologically by linear IgA deposits at the basement membrane zone. These cases usually do not show intestinal involvement and respond well to combined treatment with sulphones and corticosteroids, whereas sulphones or sulphapyridine alone are, even in very high doses, not sufficient for full control of the disease.CBDC or IgA linear dermatosis of childhood may be regarded as a counterpart of IgA linear dermatosis of adult

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1979.tb15096.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

SUMMARYOpen comedones from thirty‐eight patients with acne vulgaris on the face or back were compared for microbial flora. A total of eighty‐three comedones from the face and sixty‐three from the upper back were individually processed for quantitative bacterial analysis.The greatest difference between the flora of comedones at these two sites was that 44.6% of comedones from the back (compared to 9.6% from the face) harboured no aerobic cocci. The decreased prevalence of staphylococci in the lesions from the back reflects the relative absence of these organisms in isolated follicles from normal uninvolved skin of the back.The geometric mean count of anaerobes in comedones from the back was in the same range as the count found in isolated follicles in normal uninvolved skin in a previous study.This work supports the concept that the bacterial flora of comedones is an extension of the follicular flora and may be unrelated to the event of comedoge

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1979.tb15097.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

SUMMARYA previously undescribed short‐lived non‐pruritic reticulate erythema has been noted in several members of unrelated families with hereditary angio‐oedema. The eruption which may be widespread can last from 1 to 4 days and usually immediately precedes an overt attack of hereditary angio‐oedema although this is not invariable, and swellings may occur in areas not previously involved by the erythema. Histology including immunohistology probably shows no specific

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1979.tb15098.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

SUMMARYSeven corticosteroids were tested for their effect on the release of β‐glucuronidase when human white cells were challenged with zymosan. Stabilization was noted in two areas of dilution with every steroid but destabilization occurred at high concentrations. However, those steroids that stabilized effectively at low concentrations were also those which were the most potent vasoconstricto

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1979.tb15099.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

SUMMARYWe have shown that sera from normal individuals and from patients with pretibial myxoedema contain a factor which stimulates mucopolysaccharide biosynthesis in normal human skin fibroblasts culturedin vitro.This factor was present in larger amounts in sera of patients with pretibial myxoedema. The role of growth stimulating factors in serum is reveiwed and a hypothesis is put forward that the fibroblast stimulating factor is somatomedin and that its presence in increased amounts in thyroid disease may lead to pretibial myxoedema.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1979.tb15100.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

SUMMARYNecrosis of cutaneous and subcutaneous tissue is a rare complication of therapy of with oral anticoagulants, and is related to the use of loading‐dose regimes. Three cases are reported, and demonstrate that the principal histopathological feature is thrombosis within the subcutaneous vasculature. The effect of large doses of anticoagulant on the levels of the vitamin K dependent clotting factors provides a satisfactory model for the temporal sequence of events in this syndrome. The occurrence of intravascular thrombosis with low or absent levels of Factor VII indicates that the intrinsic clotting system is of primary importance in venous thrombosis. This complication of anticoagulant therapy is not seen if loading‐dose regimes are avoi

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1979.tb15101.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY