摘要:

SUMMARY.–The incidence of thyroid and gastric autoantibodies in the sera of 43 patients with dermatitis herpetiformis was determined and compared with the incidence in a control group matched for age and sex. Thyroid microsomal antibody was present in the sera of 9 patients in the dermatitis herpetiformis group compared with 1 patient in the control group. This difference is statistically significant. Thyroglobulin antibody was present in the sera of 6 patients in the dermatitis herpetiformis group. It was not present in the control group. The incidence of gastric parietal cell antibody was increased, but not to a statistically significant extent, in the dermatitis herpetiformis patients. The relevance of these findings to the aetiology of dermatitis herpetiformis is discusse

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15754.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.–A case of dermatitis herpetiformis elicited by the intake of milk is described. A woman aged 30 had suffered from colic, loose stools and fatigue for 3 years. Investigation revealed a severe atrophy of the intestinal mucosa, increased faecal fat excretion, and impaired xylose absorption. On a glutenfree and almost milk‐free diet the malabsorption improved, but it recurred during a period with increased milk intake; at the same time dermatitis herpetiformis developed. Following renewed milk elimination the dermatitis disappeared. On repeated provocation and elimination of milk the dermatitis herpetiformis reappeared and disappeared. During milk intake the gamma‐G, gamma‐A and gamma‐M‐globulin increased and, when milk was eliminated, they decreased. It is suggested, that in this patient the ingestion of milk provided an antigenic stimulus which was in some way concerned with the development of the s

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15755.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.–The variability of dosage of dapsone required to control dermatitis herpetiformis is well known but unexplained. As a first step in the investigation of this problem this paper describes the results of estimations of serum levels and urinary excretion levels after a single oral dose of 100 mg.35S dapsone given to patients with and without dermatitis herpetiformis. For comparison the levels were measured by radio‐activity and by chemical methods. Radiochromatographic studies were also carried out to determine the form in which dapsone circulates and is excreted. Autoradiographs of biopsies are also discus

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15756.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.–Experiments reported in this paper show that grinding up skin in tissue culture medium can release a potent stimulant to epidermal cells, causing them to go into DNA synthesis within 4 hr.in vitro.Some progress has been made in elucidating the nature of this stimulant, but it is not yet characterized. A possible role in wound healing is discusse

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15757.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.–Histological and fibrinolytic activity (FA) changes were studied in skin exposed to visible light and u.v. radiation from a monochromator. There was a marked difference in the early and late lesions produced by irradiation. Late lesions showed loss of fibrinolysis and early lesions showed little or no such change.Absence of fibrinolysis was found in upper dermal vessels in the more delayed sunburn papule reaction and in the delayed reaction in polymorphic light eruption (PLE) and actinic reticuloid, with heavy mononuclear infiltrates appearing as early as I hr. after irradiation. The lesions of PLE and “actinic reticuloid” showed absence of FA. There was no loss of fibrinolysis in the urticarial lesions of solar urticaria (as long as 5 hr. after irradiation) and in the porphyric skin reaction, or in light exposed porphyric skin.These results suggest that impairment of fibrinolysis may play an important part in the delayed reaction to sunburn in the normal, in PLE, actinic reticuloid and photosensitivity with tetrachlorsalicylanilide. By contrast, impairment of fibrinolysis is not a feature of idiopathic solar urticaria or of the more or less acute porphyric photosensitive skin rea

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15758.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.–The effect of a local increase or decrease in skin temperature on the rate of sebum excretion from forehead skin was studied in 9 subjects. The relationship between skin temperature and sebum excretion rate was highly significant, and heating and cooling produced changes of the orders of 10% per 1°C. These changes occurred within 90 min., which suggests that the sebum excretion rate measured by the present technique may not always accurately reflect the rate of sebum production deep in the glands. Variations in temperature affect the rate at which sebum is absorbed by the collecting papers, probably due to changes in sebum viscosity, and this could explain the observed changes in sebum excreti

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15759.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.–Impressions of the skin surface were taken with silicone rubber and secondary positive replicas were made with Araldite. After coating with gold they were examined with the scanning electron microscope. The openings of the sweat ducts were easily seen on the palms and soles, and each of their orifices was patent. The terminal ducts have also been identified on the surface of skin on the limbs and trunk, and the appearances of these ducts is described. By oblique rotation a patent orifice was identified for each sweat duct, and by sequential cellophane tape stripping it was shown that all the sweat ducts were patent throughout their spiral course in the horny laye

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15760.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.–Two new cases of skin infiltration by polyvinylpyrrolidone are reported. One had 2 types of macroscopic lesion: erythematous plaques, often with yellow pseudo‐xanthoniatous papules in the centre, localized round the neckline and the front of the thorax, and small fibromata on the thighs and legs. The other patient had slightly indurated skin in the epigastric region.The ultrastructure of the histiocyte infiltration consisted of dense bodies and vacuoles with various structural variations. The authors stress the extremely generalized nature of this infiltration, affecting all the cell types of the skin, and the presence of intermediary forms linking the dense bodies to the vacuoles.Acid phosphatase activity is present in the dense bodies and certain intermediary vacuoles but absent from the large vacuoles. It is suggested that the dense bodies represent lysosomes with enzyme accumulation which then become loaded with polyvinylpyrrolidone, thus leading to the formation of large vacuoles with no enzyme activity. The well‐developed Golgi apparatus in the histiocytes plays a part in the synthesis of lysosomal en

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15761.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.–The Wistar rat has been shown to be a suitable experimental animal in a model for the study of oral candidosis. The micro‐organisms penetrated the stratum corneum of the tongue and buccal mucosa producing lesions resembling those in acute oral candidosis in humans. Salivary flow as varied in this experiment does not appear to be important in the genesis of this infect

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15762.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.–A comparison was made of the histopathological features of Mikulicz's recurrent oral aphthae with 2 experimentally induced reactions in the oral mucosa of laboratory animals by the examination of sequential excision biopsies of the 3 lesions. The Mikulicz's recurrent oral aphthae possessed more features in common with the contact hypersensitivity reaction in guinea‐pig oral mucosa than with the Arthus type reaction in rabbit oral muc

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15763.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY