摘要:

Summary.—The case histories of 102 consecutive patients suffering from polyarteritis nodosa were reviewed. The 17 patients with skin lesions were personally examined and investigated. Thirteen were found to have polyarteritis affecting the skin. In one of these cutaneous involvement occurred only 4 days before death and 5 weeks after the onset of the illness. The other 12 showed remarkably similar clinical and pathological features and, together with 3 cases from another hospital, are described in detail.Only the skin, skeletal muscles and peripheral nerves were involved. No deaths have occurred to date (longest follow‐up period 23 years), and the disease is now either entirely quiescent or represented only by occasional cutaneous lesions.It is concluded that about 10% of all cases of polyarteritis nodosa, and 30% of those proven histologically, are of this benign type and that this variety can be easily recognized clinica

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb16181.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—Nine skin biopsies and 2 lymph node biopsies obtained from 6 patients with mycosis fungoides and one with Sezary syndrome were studied. Touch smears were also made. Two main cells were found in the infiltrates: mycosis fungoides cells (MC) and histiocytes. The size of the former varied between 10 and 30 μm and consequently the smaller ones were similar to lymphocytes as viewed by light microscopy. With the electron microscope they had a similar structure to the cells described by Lutzner and other writers, with slight variations according to the size of the cell. Either of the 2 cells could undergo malignant transformation, the other cell persisting as a benign associated feature. Thus mycosis fungoides can become malignant either as mycosis fungoides by malignant transformation of the MC or as reticulum‐cell lymphoma by malignant transformation of histiocytes. Neither histological nor cytological differences can be found between the MF and the Sezary synd

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb16182.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—The scaling papules of pityriasis lichenoides (PL) can at times simulate psoriasis clinically and histologically. In this study particular attention has been paid to the epidermal changes in PL, and 126 biopsy specimens from 94 patients were examined. Parakeratosis was found in 72%, invasion of the epidermis by mononuclear cells in 69%, and focal cell death in 57%. Skin surface biopsies from 8 patients and cryostat sections from 12 patients were examined histochemically. The parakeratotic scale and scattered individual keratinocytes within the epidermis demonstrated strong hydrolytic enzyme activity, and there was a diminution in the reactivity for mitochondrial enzymes within the PL papules. The labelling index was determined for 7 PL lesions after injection of tritiated thymidine and found to be 15·2%. In addition, slices of tissue from 8 PL papules were incubated with tritiated proline, and this manoeuvre also demonstrated the existence of dead and dying cells within the Malpighian layer. The suggestion is made that parakeratosis in PL is caused more by damage to the epidermis than by increased epidermopoies

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb16183.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—Eleven patients with pitryrisis lichenoides have been tested for toxoplasmosis. In 6 of them the complement fixation test, the intradermal test with toxoplasmin and the Sabin‐Feldman test were repeatedly strongly positive. The same patients reported continuous occupational animal contact. Both the toxoplasma‐positive patients and 3 negative patients were submitted to treatment with pyrimethamine. All 6 toxoplasma‐positive patients responded very favourably: 3 were completely cured. 75 clearance of lesions was obtained in 2 and 50 in one. The 3 toxoplasma‐negative patients failed to improve.The authors believe thatToxoplasma gondiiinfection may play an aetiological role in pityriasis lichenoides. More observations are needed in order to corroborate or to reject this su

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb16184.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—The ultrastructure of lichen amyloidosus has been studied with special reference to the epidermal changes. The amyloid deposits often came into close proximity to the lower epidermis and obscured the basal lamina. Occasionally, breaks in the basal lamina occurred so that amyloid fibrils came into direct contact with the cytoplasm of basal cells. Small deposits of amyloid were sometimes seen in the inter‐cellular spaces between basal cells. Focal areas of liquefaction degeneration were observed within a number of basal cells. A few keratinocytes in the upper epidermis contained deposits of amyloid‐like fibrils. It is suggested that these amyloid‐like fibrils probably represent degenerate tonofilaments rather than true

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb16185.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—Nineteen members in 4 successive generations of one Chinese family in Malaysia were found to have classical lichen amyloidosis without systemic amyloid involvement. The disease was transmitted as an autosomal dominant trait with variable penetrance. Sex ratio was equal and the onset was around the age of puberty. The extent and severity of the lesions tended to increase with age. No patient subsequently developed the systemic form of amyloidosis.The present findings further strengthen the genetic theory of lichen amyloidosi

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb16186.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—Factors involved in the formation of erythrasma lesions are discussed. In the axillae and groins, the presence of scaling was a significant forerunner of the appearance of a fluorescent lesion. The total bacterial count, the counts of both fluorescent and non‐fluorescent diphtherolds, were highest in areas showing both fluorescence and scaling, but the number of micrococci did not differ significantly between affected and non‐affected

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb16187.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—In 2168 infants, 17 cases of strawberry mark were followed from the earliest neonatal stage. Three angiomata began as telangiectatic lesions surrounded by a pale halo; red puncta then appeared on the dilated vessels. They coalesced and became papular, and red plaques were formed. Three angiomata began as a pale patch; telangiectasia then appeared on this patch. One angioma, first seen as a bruise‐like macule. transformed into a nodular lesion. One angioma began as a simple and uniform erythema and subsequently became nodular. Two infants already showed early haemangiomata at our first examination. In 5 infants, on whom no abnormality was found within the first week of life, a strawberry mark was found later. Two pale patches in the neonatal stage remained abortive angiomata. The haemangiomatous component developed in the majority of cases between the third and fifth weeks of l

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb16188.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—One hundred and thirteen patients with industrial dermatitis were reviewed 10–13 years later. Seventy‐nine per cent still required treatment from time to time. Cement dermatitis had a significant worse prognosis than oil dermatitis. Only 8 of cases of cement dermatitis were clear.In a review of cases for which industrial injuries benefit is paid in Northern Ireland there were about 150 successful claims for contact dermatitis per year this being about 1 of all industrial injuries occurring in a working population of 500,000.The incidence of dermatitis diminishes with age, but the risk has been reduced by only about 50 in the older age group 55–64 compared with the younger age grou

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb16189.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—The activity of 14 enzymes representative of the main metabolic pathways was assayed with microfluorometric techniques in the epidermis of exposed and unexposed skin of old men.The activity of 9 enzymes (α‐glycero‐phosphate dehydrogenase enolase, lactic dehydrogenase, isocitric and malic dehydrogenase, glucose‐6‐phosphate dehydrogenase, alanine and aspartate tranaminase. β‐hydroxylacyl dehydrogenase) was decreased in the exposed skin of old humans.The decrease of the activity of many enzymes in the exposed skin seems to be due to the accumulation of damage to ep

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb16190.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY