摘要:

SUMMARY.—As part of a study on the effect of water on the extensibility of isolated corneum we have investigated the effect of temperature on extensibility under conditions where the corneum water content was kept as constant as possible. The results showed that corneum extensibility was decreased at lower temperatures. These results may be of significance in the appearance of skin chapping in winter. The incidence of chapping has been related to low dewpoints and the hypothesis was that a low dewpoint leads to a low corneum water content. Our results suggest that low temperatures play an equally important part and that chapping is not related purely to a low corneum water conten

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15930.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—Using an electrolytic hygrometer, the Transepidermal Water Loss (T.W.L.) from the skin was measured in normal individuals and in patients with dermatitis (eczema). It was found that there was a close correlation between T.W.L. and the state of activity of the dermatitis; and that there was a gradual reduction in abnormally raised T.W.L. in parallel with the return to normal of the skin response (dermatitis). Sweating did not contribute to the increased insensible water loss in dermatitis under the fixed limits of ambient temperature and humidity of this investigatio

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15931.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—A method to evaluate sunscreensin vitrois described. It employs light, photography and densitometry. The measurements are compared and analysed with the assurance that an equal amount of light bombards the sensor for an equal length of time, passing through a uniformly spread barrier of sunscreening material, to a film of uniform spectral sensitivity. The protection provided from mid‐day sunlight and artificial erythemal light by 9 agents is compared and correla

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15932.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—An investigation into the pathogenesis of the occupational skin disorder known as “tulip finger” showed it to be determined by an allergic mechanism. This is in line with the findings of some other investigators.Paper‐chromatography of active extracts from tulip bulbs, and subsequent patch‐tests with these paper‐chromatograms in sensitized individuals, made it possible to localize the allergic principle in the paper‐chromatograms and to find a reagent (Tollens) for chemical spot tests with the active agent. In later experiments we used the Tollens reaction to locate the active substance in paper‐chromatograms, without doing patch tests.A quantity of “crude allergen” was obtained by preparative paper‐chromatography.Qualitative analysis indicated a compound related to sugars, which is probably a glucoside. Hydrolysis of this compound yielded glucose, and a substance identified by chemical, spectroscopic and gas‐chromatographic methods as: α

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15933.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—A group of 9 patients is presented in whom painless loss of nails is the principal cutaneous abnormality. The nails are normal at birth but after a few years one or more finger or toe nails become affected. The condition is progressive for a time but then remains stationary and no further nails are involved. The nail changes range from discoloration and ridging, through pterygium formation to permanent total loss with obliteration of the nail fold. Some nails remain quite normal. The condition occurs without apparent cause and is apparently not genetically determined. The diseases with which it is most likely to be confused are nail loss from lichen planus or from impaired peripheral circulatio

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15934.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—Two anephric patients on twice weekly maintenance haemodi‐alysis developed staphylococcal infections of their Scribner Teflon‐silastic arteriovenous shunts. Both patients were treated with very large doses of cephaloridine and cloxacillin in an attempt to preserve the shunts.Shedding of finger and toe nails developed in both patients some 6 to 12 weeks after the start of antibiotic therapy. Regrowth of the nails occurred nor

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15935.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—A case of lichen myxoedematosus is described in which multiple serum protein abnormalities have been demonstrated by disc electrophoresis, in addition to the previously described abnormal basic globulin fraction migrating in the post‐gamma region on paper electrophoresis.Immunohistological studies indicate that there are abnormalities in the connective tissue between the collagen bundles as well as deposition of IgG globu

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15936.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—Neutron activation analysis was used to determine zinc levels in samples of normal skin taken from 36 cadavers. The ratio between epidermal and dermal zinc concentrations was found to be about 6: 1. This gradient in zinc levels between the epidermis and dermis plus the remarkably narrow range of values found in the two structures suggest that this element plays an important role in the metabolism of human skin. The sensitivity of the method used in this study makes it ideal for application to pathological skin conditions where only very small amounts of material are availabl

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15937.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—Two brothers with hereditary angio‐oedema have been studied, the only 2 cases among 227 patients with angio‐oedema seen in 10 years. The absence of the inhibitor of the activated first component of complement in their serum confirmed the diagnosis. In a double blind trial their symptoms were partially controlled by ε ‐ aminocaproic acid, although there were no consistent changes in the serum complemen

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15938.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—A case report of a patient with cutis verticis gyrata, in whom an additional scalp abnormality had supervened, is presented. Histologically, the latter was composed of fibrous tissue in which there were foreign body granulomata around embedded hair shaft

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15939.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY