摘要:

Summary.—An attempt has been made to detect Ig deposits in skin and upper intestinal mucosa, and circulating antibodies in the serum, of patients with dermatitis herpetiformis.Deposits containing IgA and complement (C3’) were traced in the lesional skin of 11 of 12 patients. One patient wbo was free of skin symptoms failed to exhibit similar findings.Specimens of upper intestinal mucosa (9 patients), did not show a similar pattern of junctional IF; however a marked flattening of the mucosal relief was observed in 6 patients.Circulating antibodies against junctional antigens of skin or jejunal tissue were not demonstra

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1971.tb14074.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Summary.—A postal survey of patients with dermatitis herpetiformis (DH) has yielded information about 445 cases. Only just over half of these knew the name of the disease from which they were suffering. Our findings in relation to age and sex distribution of the patients are similar to those previously recorded. Patients may develop the disease at any age, including old age. Remissions are common, although we are unable to calculate the recovery rate. Dapsone is the drug most often used in treatment, and some patients seem to be taking more than they need to control their rash: a plea is made for the use of the minimal effective dose. Only a small percentage of patients are aware that they have small bowel disease, and we interpret this as indicating that small bowel mucosal biopsy is not being done as a routine in patients with D

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1971.tb14075.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Summary.—This paper deals with the pathogenesis and the microscopic and cytological features of the pemphigus group of diseases. The immunological aspects of acantholysis are discussed. The statement by several authors that pemphigus is an autoimmune disease is questioned and evidence from the literature against this hypothesis is cite

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1971.tb14076.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Summary.—Biopsies from 10 patients with lichen amyloidosus were investigated histochemically with special reference to the epidermal changes. The number of dopa‐positive melanocytes was markedly decreased in the epidermis overlying the amyloid deposits, indicating that melanocytes are also involved and probably destroyed by the disease process. No increase in lysosomal enzyme activity could be detected in epidermal cells undergoing degeneration or in the epidermis immediately above the amyloid deposits. Respiratory enzyme activity was moderately reduced in the epidermis overlying the amyloid deposits. These histochcmical findings confirm that the epidermis is likely to be involved in the histopathogenesis of lichen amyloidosus. It is suggested that, prior to the deposition of amyloid, a specific cellular tolerance may develop to the presence of necrotic epidermal cells in the region of the dermo‐epidermal jun

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1971.tb14077.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Summary.—Immiunofluorescence studies suggest that complement components play a part in bringing about the clinical cbanges in light‐exposed skin of patients with symptomatic and hereditary porpbyria cutanea tarda.Due to photodynamically induced permeability cbanges formed serum elements occur in and around the blood vessel walls of the light‐exposed skin.No indications were found of a primary auto‐immune mecbanism operating in porphyria cutane

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1971.tb14078.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Summary.—A case of erythropoietic protoporphyria is described. To our knowledge this is the second to be reported in Jugoslavia. The disease started at 3 years of age, with skin photosensitivity. burning and itching of the face and hands. Symptoms and signs were present almost throughout the year, with only short periods of freedom. In recent years the disease had tended to decrease in severity, but lately she has developed some bullous haemorrhagic lesions on the feet.Increased values of RBC protoporphyrin, and to a lesser extent of coproporphyrin, were found. Increased values of faecal protoporphyrin and coproporphyrin were also found. Urinary porphyrins were within normal limit

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1971.tb14079.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Summary.—A patient with peripheral vascular disease, annular erythema and Sjögren's syndrome is described. A selective IgA deficiency, which was not apparent on routine serum protein electrophoresis, and mixed cryoglobulinaemia were additional features of her autoimmune disea

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1971.tb14080.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Summary.—Six cases of allergic reactions to green algae are recorded. Five patients had atopic dermatitis in which exacerbations were provoked both by inhalation and by direct contact with algae. These patients also reacted to lichens, which contain algae in symbiosis with fungi. Five of the patients had allergic rhinitis or asthma, often very mild in relation to the severity of the skin symptoms. Three of the patients also had a delayed hypersensitivity contact dermatitis from lichens, but not from algae.It is important to investigate patients with suspected sensitivities to lichens and algae both by patch testing and by prick testing as specific desensitization may help those patients with immediate weal reaction

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1971.tb14081.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Summary.—In idiopathic onycholysis, nail growth has been found to be significantly taster than normal. An increase of similar magnitude was found in psoriatic onycholysis. We are unable to say whether increased nail growth is of pathogenic importance or is simply a consequence of onycholysis. The hypothesis that idiopathic onycholysis is “pre‐psoriatic” was tested by measuring growth of uninvolved nails in both idiopathic and psoriatic groups; the clinically normal nails of psoriatic patients grew significantly faster, and those in the idiopathic group marginally more slowly than normal. These findings, combined with a significant difference in the fingernails involved in the ony‐cholytic process, lead us to conclude that idiopathic onycholysis is not “pre

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1971.tb14082.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Summary.—Normal human epidermis was homogenized and separated into “heavy mitochondrial”, “light mitochondrial”, “microsomal” and “soluble” fractions by differential centrifugation in the cold. The homogenate and the subcellular fractions were investigated on fibrin plates for their fibrinolytic activity, their inhibitor activity against urokinase, and proactivator activity.No direct fibrinolytic activity was demonstrated in the homogenate or the suhcellular fractions, but they showed inhibitory activity against urokinase and strong fibrinolytic activity following streptokinase treatment. Both activities were predominant in the soluble fraction. Weak activity was also found in particulate fractions. The distribution pattern of both activities in subcellular fractions was very similar. The possible existence of a complex of proactivator and inhibitor in the epide

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1971.tb14083.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY