摘要:

SUMMARYImage analysitig computers can perform quantitative measurements of epidermal thickness, sebaceous gland volume, and labelling indices of epidermis easily, rapidly and automatically. All these para‐meters are extremely important in investigative dermatology and this paper describes how they are measured using the Quantimet 72

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb00834.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYBlaschko's lines are the pattern assumed by many different naevoid and acquired skin diseases on the human skin and mucosae. They were described and drawn by Blaschko 75 years ago. These lines are to be distinguished from other linear patterns such as Voight's lines, Langer's lines, and the lines of innervation of the spinal nerves. They do not follow any known nervous, vascular or l5rmphatic structures in the skin. The epidermis and its appendageal structures, the melanocytes, the vascular system, and the fatty hypoderm, all, separately or in combination, may be involved in the morpho‐logical manifestations which follow Blaschko's lines. Many of the naevoid skin conditions are lifelong (e.g. linear sebaceous naevus, unilateral naevoid telangiectasia); many of the acquired skin diseases (e.g. lichen striatus, linear psoriasis) are of relatively short duration (e.g. 1–2 years). The cause of the distribution pattern is unknown. It is possibly a form of human‘mosaicism’ where certain specific cells or groups of cells react differently from other cells due to chromosomal abnormalities. The embryological explanation of Blaschko's lines is not at all clear. Other markers in addition to the skin findings are needed to determine the time and the nature of the change responsible for these lines. The main purpose of this article is to introduce the concept of Blaschko's lines into the medical, paramedical, and general biological fields of science. In this way, it is hoped that some inter‐reaction can occur between those who regularly see Blaschko's lines and those who regularly see and study other chromosomal and embryological abno

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb00835.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYThe effect of collagenase on the‘T’ and‘B’ markers of peripheral blood lymphocytes was studied in five healthy male blood donors. No significant difference between untreated and collagenase treated lymphocytes was found. Collagenase is recommended for use in liberating living cells from skin biopsy sp

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb00836.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYA 15–17 year follow‐up study was conducted on ninety‐nine patients who had suffered from infantile eczema. The persistance of the eczema and the occurrence of related conditions were noted. The per‐sistence of eczema was shown to be greater in those patients with a positive family history of eczema and in those who had developed asthma or hay‐fever. An attempt was made to see if the persistence of eczema was affected by the position of the child in the family, and some factors provoking relapses were noted.The patients were also questioned with regard to their achievements in academic examinations, and to their social, artistic and sporting activities. The results showed a success rate in examinations not significantly higher than average. It was not possible to show if there is a particular type of atopic personality. There was no constant characteristic in social or artistic patterns. The group as a whole were normal at the milestones of early development, i.e. walking, talking and reading, and also normal with regard to weight a

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb00837.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYTests designed to measure psychopathological characteristics common to the neurotic population were administered to patients with atopic dermatitis, patients with other dermatological disorders and to control group of normal individuals. The parameters tested were manifest anxiety, neurosis, extro‐version, depression, hypochondriasis and hysteria. The scores were statistically analyzed. The results showed that patients with atopic dermatitis responded significantly differently from patients with other dermatological diseases and from the control group in specific psychometric scales. Moreover, patients with skin conditions other than atopic dermatitis also responded significantly differently from the control group. The study clearly shows that patients with atopic dermatitis have a characteristic psychological profile not shared by the other two groups. The atopic dermatitis patients tend to be in state of high manifest anxiety, depressed, neurotic and hypochondria

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb00838.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYSeven patients with a macroscopic response resembling an Arthus reaction, and occurring 2–4 h after intracutaneous injections of staphylococcal particulate antigens or total staphylococcal extract, were examined for the appropriate specific antibodies that activate complement, and by immunofluores‐cence for antigen, immunoglobulin and complement in the reaction site.Four of the patients had serum antibody, and skin reactions with the typical features of early Arthus reactions and containing immunoglobulin, complement and antigen. Three patients had apparently‘non‐allergic’ responses. They lacked appropriate antibody in serum and immunoglobulin deposits in the lesions, though all except one had complement deposits in reaction sites. One of the three neverthe‐less had histological changes typical of an Arthus response. Lymphocytes teased from the reaction site skin of one patient with a‘non‐allergic’ 4 h response comprised 35 B cells bearing IgG out of 200 counted.The nature of the‘non‐allergic’ response reaching a maximum size at about 4 h macroscopically, and in some instances microscopically resembling an Arthus response, is still to be determined but it illustrates the caution necessary in interpretation of skin tests

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb00839.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARY1058 newborn infants were examined. Forty‐one (39%) had clinically discernible pigmented lesions compatible with melanocy tic naevi. Biopsy was performed on thirty‐four of the forty‐one and of these; eleven, representing 1.01% of the infants, proved to be melanocytic naevi. No giant (garment) naevi were seen in this series. Two of the eleven naevi pathologically examined showed histological changes similar to those that have been reported in some giant naevi, but the remaining nine were not only different from criteria usually assigned to giant naevi, but they also differed from the usual adult naevi, in that most were predominantly junctional. None of the melanocytic naevi in this series showed any suggestion of malignant change. In newborn infants it is often impossible clinically to distinguish naevi from other types of pigmented lesions, as only eleven out of the thirty‐four pigmen‐ted lesions were melanocytic naevi. Seven of the eleven melanocytic naevi were under 1.5 cm in diameter. No pigmented lesions were found on the palms, soles or

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb00840.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYProstaglandin biosynthesis from arachidonic acid by skin microsomal fraction preparation was enhanced by UV∼irradiation at wavelengths of 254 and 360 nm. In the presence of S‐methoxy psoralen (8 MOP) and coal tar, prostaglandin biosynthesis was further enhanced approximately 2‐fold by UV‐irradiation at 254 nm. Stimulation was less by UV‐irradiation at 360 nm.8‐MOP enhanced the conversion of PGE, into PGF2αby PGE2‐9‐ketoreductase prepared from skin high speed supernatant fractions. UV‐irradiation at 254 nm and 360 nm with or without the photosensitizers had no effect on the activity of the PGE2‐9‐ketoreductase.These data therefore indicate that the action of UV‐irradiation, 8‐methoxy psoralen and coal tar on the skin may in part be due to their regulation of the biosynthesis and metabohsm of pros

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb00841.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYSpecimens from two cases of subcutaneous fat necrosis of the newborn were studied by light and electron microscopy. Crystallization of the fat cell started with clearing of the central fat droplet, followed by the appearance of cylindrical crystals. The fat crystals were phagocytoscd by cytoplasmic projections of macrophages as well as by foreign body giant cells. Calcium deposits were demonstrated within the central fat droplet of the degenerated fat cell of Case 2.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb00842.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYWorkers in the precision engineering industry who readily corrode metal are known as‘rusters’. We have described two patients with this condition, and review current ideas with regard to its cause, detection, prevention and treatm

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb00843.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY