摘要:

SUMMARYPlatelet counts were obtained in 60 patients with gravitational ulceration (GU), 60 with gravitational eczema (GE), 56 with endogenous eczema (EE) and 60 normal controls. Mean platelet volume (MPV), a broad index of platelet size, was estimated in the last 40 patients in each group (29 with EE). Causes of a reactive thrombocytosis were excluded. Platelet counts were significantly higher in both gravitational groups than in the EE group or the normal controls (P= 0.001). Ulcer healing produced no significant changes in platelet count, and patients with non‐gravitational ulcers had normal platelet counts.MPV was significantly higher in both gravitational groups than in controls after correction for platelet count, by analysis of co‐variance (P= 0.001).These differences in platelet parameters in gravitational disease suggest a possible role for platelets in this disease, and platelet inhibiting therapy may be of value at an early stage in the development of the condit

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb05761.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SUMMARYThe effect of a platelet homogenate fraction (PHF) on epidermal cell outgrowth from porcine skin explants was examined in culture medium with and without 5% foetal bovine serum (FBS). Explants were sustained and outgrowth was initiated, supported and stimulated by PHF, in the absence of FBS. PHF‐supported outgrowth was concentration‐dependent up to 130 μg protein/ml. PHF activity was not removed by heat treatment at 100° C for 2 min but was destroyed by heating at 100° C for 5 min. The factor responsible for epidermal cell outgrowth in PHF may be epibolin or serum spreading factor, or may be a platelet‐derived factor as yet undescribed. Viability and outgrowth were stimulated by the ‘high molecular weight’ fraction of PHF (>30 kd). PHF plus 5% FBS gave inhibition of outgrowth, which was not PHF concentration‐dependent; however, this inhibitory effect was variable with different PHF preparations. This study is the first to demonstrate an effect of platelet‐derived factors on epidermal cell viabili

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb05762.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SUMMARYRecombinant rat IFN‐γ was found to induce Ia antigen expression on rat keratinocytesin vivo. Strong expression of Ia antigen on keratinocytes of rat ears was produced after intradermal injections of 10 000 U IFN‐γ once daily on 3 successive days. The expression was still pronounced 2 days after the last injection, but had disappeared 4 days

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb05763.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SUMMARYVarious strains of cutaneous micro‐organisms were testedin vitrofor their survival rates in 0.5 mol/1 (8.4% w/v) azelaic acid solution. All bacterial strains exhibited large reductions in viability (at least 40‐fold) over a 24 h test period, but little response was noted withPityrosporumovale. The bactericidal effect of azelaic acid was reduced considerably in the presence of nutrients. Minimum inhibitory concentrations (MICs) and minimum bactericidal (or fungicidal) concentrations (MBCs) were also determined. MICs varied from 0.03 mol/1 to 0.25 mol/1; MBCs were all either 0.25 mol/1 or grea

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb05764.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SUMMARYUsing scanning electron microscopy to study molluscum contagiosum lesions, it has been possible to demonstrate a unique, well defined sac enclosing the virion colony of each infected keratinocyte. This confirms the presence of a structure demonstrated over 50 years ago by micro‐dissection, but ignored since it is not seen on either light or transmission electron microscopy. It is postulated that this sac, of unknown origin, favours replication of the virions by providing a site that is both anatomically and immunologically privileged. Such relatively unimpeded growth of the virions results in an enlarged cell in which the cytoplasm and nucleus are compressed into a thin outer shell. In the aggregate, this produces a tumour of virus‐packed cells rather than a tumour composed of virus‐induced cell hyperp

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb05765.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SUMMARYSixty‐two patients with 67 large or poorly defined skin tumours predominantly on the head and neck (58 basal cell carcinomas) were treated by excision of the lesion and allowing the defect created to heal by second intention. Histological control of the adequacy of excision was monitored using routine vertical sections of formalin‐fixed tissue. Further re‐excisions were performed in 17 patients in whom tumour extended up to or within 1 high power field (approximately 0.44 mm) of the excision margin. The formalin‐fixed specimens ranged from 6‐60 (mean 21) mm in diameter and 2‐12 (mean 5) mm in depth. After one excision the time to complete re‐epithelialization was directly proportional to the surface area (r= 0.73) and ranged from 13 to 60 days (mean 33 days). Measurements of the movements of fixed reference points tattooed at the wound edges in six patients showed that movement of surrounding tissue into the defect accounted for 39–62% (mean 45%) of the reduction in surface area of the defect during healing. Post‐operative complications were rare and the cosmetic results were considered good or excellent in 48 patients, fair in nine and poor, i.e. requiring corrective surgery, in three patients. Poor results were due to distortions of free margins, e.g. lower eyelid and nasal margin. The major benefit of this technique is the ease with which further excisions can be performed when histologically indicated. In selected areas this simple and quick technique avoids the need for repair with full thickness grafts or flaps, and the defect shrinkage and excellent contour and colour matching produce cosmetic results superior to those of split skin grafts or follo

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb05766.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SUMMARYIn a study of 651 patients with cutaneous malignant melanoma and matched controls, no association was found with a history of acne vulgaris or psoriasis. Examination of the severity, age at onset and treatment for acne or psoriasis, and analysis by age, sex and site distribution of melanoma, revealed no evidence of any association.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb05767.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SUMMARYTwenty patients with palmoplantar pustular psoriasis were treated initially for 4 weeks with 70 mg etretinate daily. This led to clinical improvement and a significant fall in pustule count. The patients were then allocated randomly to 30 mg etretinate daily or placebo for a further 12 weeks. There was a rapid deterioration in the clinical condition and a rise in pustule count in the placebo group. The etretinate‐treated group still showed clinical improvement and a significantly lower pustule count after 12 weeks. Clinical side‐effects were few and adverse effects on liver function and serum lipids were not fo

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb05768.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb05769.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SUMMARYA clinically typical case of Bazex acrokeratosis neoplastica is presented. This case is unusual in that the syndrome developed two years after a neoplasm was diagnosed. Almost complete clinical clearance was obtained with oral Tigason®, making it the first recorded case to improve without removal of the underlying neoplasm

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb05770.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY