摘要:

SUMMARYThe cell proliferation kinetics of the germinative compartment in psoriasis have been re‐investigated with tritiated thymidine and vincristine techniques. The mean cell cycle durations calculated from an extended fraction of labelled mitoses experiment were Tc= 56 h, t1= 43 h, ts= 7.7h and t2= 5.6 h. Combination of the results of the FLM experiment with the experimental labelling index and the experimental birth rate suggests a growth fraction of unity and an exponential age distribution for the germinative population. An exponential age distribution is supported by the presence of several layers of germinative cells and the direction of the mitotic axes during cell divisio

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb06112.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYLocal 8‐methoxypsoralen black‐light treatment was carried out on sixty‐two patients. For the first time, oil was employed as a preparation base in order to increase the transparency and so the effectiveness of irradiation. Also the need for a descaling pretreatment was avoided. In investigations still being carried out, 27.5% patients showed very good improvement, 48.4% good and 24.2% unsatisfactory results of treatment. In many cases, less than fifteen irradiation sessions were necessary for clinical healing. However, to obtain a uniform pigmentation, additional irradiation proved nece

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb06113.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYThe rate and pattern of epidermal lipogenesis from [14C] glucose were measured in fifteen patients with psoriasis and three with lichen simplex, compared with twenty controls. In ‘uninvolved’ epidermis from psoriatic subjects the mean lipogenic rate was slightly raised, although the increase was not statistically significant. There was a positive correlation between overall lipogenic rate and the percentage of isotope appearing in free sterol, while the relative proportions of the other lipid classes were unchanged. By contrast, in control epidermis sterol percentage was negatively correlated with lipogenic rate.In psoriatic lesions total epidermal lipogenesis (per unit surface area) was raised compared with matched control ‘uninvolved’ epidermis. Also raised were percentage labelling of free sterol and of combined (free sterol and monoesters), and the free sterol: monocstcr ratio was increased. Similar findings were obtained with lesions of lichen simplex, suggesting that disturbed sterol metabolism may be a common feature in conditions of abnormal keratin

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb06114.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYThe histological features of 149 trichilemmal cysts removed from sixty‐five patients are reviewed and related to the clinical findings. These cysts, which may be solitary or multiple, gradually increase in size and number, and may produce daughter cysts by budding. When a breach occurs in the wall, inflammatory cells pour in but do not replace the cyst wall. This event may be followed by healing from the margins of the breach, by marsupialization to the overlying epidermis and thus natural resolution, or by proliferation to produce a pseudo‐epitheliomatous change which can be confused with a well differentiated squamous cell carcin

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb06115.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYThree patients with Wegener's granulomatosis are reported. All three had skin, nose, sinus, mouth and pulmonary lesions; one had severe renal involvement as well. In two patients combined treatment with low‐dosage systemic corticosteroids, azathioprine, and cyclophosphamide resulted in rapid clinical improvement and complete disappearance of the skin, mouth, nasal, sinus and pulmonary lesions. In one of these two patients who had severe renal involvement, proteinuria greatly diminished and arrest of progression of renal insufficiency was observed. In the third patient combined treatment with azathioprine and cyclophosphamide resulted in complete remission of skin, mucous membrane, lung and sinus lesions. The patient with severe renal involvement is alive and ambulant 4 years after the onset of the disease, the other two are completely symptom‐free and well 21/2years and 1 year after the onset of their illnesses, respectively.These results confirm previous reports about the effectiveness of immunosuppressive and cytotoxic agents in Wcgener's granulomatosis, the use of which seems to have improved the prognosis significantly in a disease previously considered to be fatal within 5 mon

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb06116.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYThe use of a battery of challenge tests in the routine investigation of patients with chronic urticaria has an important place, demonstrating an exacerbating factor in over half the patients. Diets designed to reduce the ingestion of the substances concerned are associated with clearing or considerable improvement in 75% of the patients treated.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb06117.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb06118.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYImmunofluorescence techniques were used to demonstrate the presence of immunoglobulin (Ig) and complement (C) bearing polymorphonuclear leukocytes (PMNL) in specimens of skin from the lesions of ten patients with allergic contact dermatitis and of ten with psoriasis vulgaris.The distribution patterns of these Ig‐ and C‐coated cells in the peripheral blood of the twenty patients were also studied. Ten normal healthy controls were included.In cases of allergic contact dermatitis, IgD was the predominant class of Ig on the PMNL. The percentages of C‐bearing PMNL were also significantly increased, suggesting that both molecules might be present on the cell membrane of these cells at the same time.In psoriasis vulgaris, the predominant class of Ig on the PMNL was IgG. The percentages of PMNL coated with C were not significantly raised.These results suggest that in allergic contact dermatitis the PMNL can be coated with both Ig and C which may render them cytophilic; they also show that in psoriasis vulgaris PMNL can bind Ig.In the ten healthy controls, it was possible to distinguish between those PMNL which are and those which arc not bearing immunoglo

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb06119.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYAcute dermatitis developed in a fisherman after contact with old cherry‐wood. APyemoiesmite, probablyP. beckeri, found in the wood, was thought to be responsible—thus illustrating the importance of appropriate laboratory examinations for ectoparasites. Human skin eruptions caused by indigenous, in contrast to imported,Pyemotesspecies have not previously been reported in Britain. These tarsonemoid mites attack small insect hosts and their possible role in dermatoses is discussed. Dermatitis caused by these mites is probably world‐wide in distribution, but during the last century the confusing acarologicat nomenclature surroundingPyemoteshas resulted in an equally confusing variety of dermatological diag

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb06120.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYSebum excretion rate was measured before and after occlusion of the skin in eleven subjects. The sebum excretion rate rose significantly following occlusion, confirming the view that there is an obstruction to the outflow of sebum with keratin hydration.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1976.tb06121.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY