摘要:

summaryThe frequencies of the major histocompatability complex class I, class II and class III antigens were determined in 130 patients (88 women and 42 men) with chronic discoid lupus erythematosus, and compared with those of 764 healthy controls. A significant increase in HLA‐B7 (38.0% in the patients vs. 25·8% in the control group), HLA‐B8 (29·5% vs. 17·4%), HLA‐Cw7 (58·9% vs. 26·1%), HLA‐DR2(46·9% vs. 29·7%), HLA‐DR3 (32·0% vs. 19·4%), HLA‐DQwi (76·6% vs. 60·5%), and a decrease in HLA‐A2(41·9% vs. 55·7%) was found. The calculated relative risk values for the respective antigens markedly increased when two or more antigens were present in one patient, with a maximum relative risk value of 7·4 for the combinations of HLA‐Cw7, DR3, DQwiand HLA‐B7, Cw7 and DR3, which were found in 17·2% of the patients

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb06258.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

summaryNormal human keratinocytes and the keratinocyte‐derived cell lines NCTC 2544 and A 431, were exposed for different periods (i–5 days) to various concentrations (0·023–46.6 μg/ml) of nickel (Ni2+). A dose‐ and time‐dependent inhibition of cell growth and viability was observed. Cultures exposed to 2·3 μg Ni2+/ml showed approximately 50% cell survival at 5 days. An increase in release of interleukin I by keratinocytes was detected following culture for 24 h with a Ni2+concentration of 2·3–11·5 μg/ml. Short periods of incubation (30 min) with these concentrations induced an activation of lipoxygenase in leucocytes from healthy subjects, without modifying cell viability. The results suggest that the percutaneous penetration of small amounts of Ni2+can result in damage to keratinocytes and can init

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb06259.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

summarySkin mast cells of five patients with mastocytosis/urticaria pigmentosa and from four normal controls were immunophenotyped with a panel of 17 monoclonal antibodies; peripheral blood mononuclear cells from the patients were similarly labelled and analysed by flow cytometry. Cutaneous mast cells expressed leucocyte common antigen and markers of macropahe/ monocyte lineage suggesting a common progenitor in the ontogeny of the two cell types. The mast cells from the patients differed from the controls, expressing HLA‐DR in four cases, and this may be a feature of proliferating cells. The patients' peripheral blood T lymphocytes showed a marked increase in the activation markers HLA‐DR and CD25suggesting a contributory role, possibly via cytokines, in driving mast‐cell prolifer

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb06260.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

summaryThe distribution and localization of several neuropeptides were investigated in the lichenified lesions of 11 patients with atopic dermatitis using indirect immunofluorescence. Substance P‐positive nerve fibres were observed in most of the cases of atopic dermatitis, but not in normal controls. Somatostatin immunoreactive nerves were not found in the skin of atopic dermatitis, whereas a normal pattern of immunoreactivity could be detected in most of the healthy subjects. Neuropeptide Y‐positive dendritic epidermal cells were observed in lesional skin from patients with atopic dermatitis, but not in controls. Calcitonin gene‐related peptide and vasoactive intestinal polypeptide immunoreactivity in patients with atopic dermatitis did not differ from that in healthy subjects. With galanin antiserum a diffuse intracellular staining was observed in the epidermis of both atopic patients and controls, while no positive staining was found with either neurotensin or neurokinin A antibodies in either group. These findings suggest a possible involvement of some neuropeptides in the pathomechanisms of atopic derma

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb06261.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

summaryTwenty‐two patients receiving etretinate were studied in an attempt to clarify the changes in hair cycle dynamics responsible for etretinate alopecia. Shed hair counts and telogen counts on samples of plucked hair were performed prior to therapy and after 6 and 12 weeks' treatment with etretinate. No evidence of anagen effluvium was found. In two individuals there were findings compatible with a classical telogen effluvium, but these had atypical features. The main finding in the study was an increase in the plucked telogen count, maximal at 12 weeks. As an arrest in the onset of anagen could produce only a comparatively small telogen increase, the predominant cause of this increase was a decrease in the duration of anagen. In two subjects there was also evidence of a telogen anchorage defec

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb06262.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

summaryA case is described of a man with multiple papillomas on the nipple that resembled clinically and histologically condylomata acuminata. Human papillomavirus (HPV) type 41 DNA sequences were detected in the biopsy material. There was no evidence of any immunodeficiency.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb06263.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

summaryA retrospective study was made of the histopathology of axillary skin excised fom 12 patients with hidradenitis suppurativa. In the majority of cases (10 out of 12), squamous epitheliumlined structures, in the form of cysts or sinuses were identified in the dermis. Laminated keratin was present in all these structures and half of the cysts also contained hair shafts, suggesting that they are derived from hair follicles. Only a small proportion of cases (4 out of 12) displayed inflammation in apocrine glands, and in these the inflammation was also seen around eccrine glands, hair follicles and the epithelium‐lined structures. However, in cases where the epithelium of the ‘cysts’ was disrupted, the inflammatory infiltrate appeared to be centred around these areas. These observations suggest that the squamous epithelium‐lined structures, which probably represent abnormal dilated hair follicles, are a more constant diagnostic feature in hidradenitis suppurativa than inflammation of apocrine glands which appears to be a secondary phe

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb06264.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

summaryShort‐chain fatty acids from the socks and feet of subjects either with strong foot odour or with weak or no foot odour were extracted with ethyl ether, and then analysed by gas chromatography/mass spectrometry (GC/MS). Short chain fatty acids were found in greater amounts from those subjects with strong foot odour. Iso‐valeric acid was present in all the subjects with foot odour but was not detected in those without. Olfactory evaluations of the various shortchain fatty acid solutions were in agreement with the GC/MS analyses. By incubating sweat and lipid from subjects with strong foot odour, we succeeded in reproducing the foot malodour. GC/ MS analyses of reproduced foot odour revealed that short‐chain fatty acids were present in a similar composition to that foundin

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb06265.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

summaryWe have investigated whether C 57 Br‐6 mouse skin with all its follicles in the telogen stage of the hair cycle contains a hair‐growth inhibitory activity, as opposed to skin with anagen follicles. Crude aqueous extracts of whole telogen mouse skin (TE), anagen skin (AE) or vehicle alone (V) were injected intraperitoneally into mice in which anagen had previously been induced by plucking of telogen hair follicles. Injection of TE, but not AE or V, significantly retarded the development of anagen follicles, as measured by macroscopic and quantitative microscopic hair growth parameters (skin pigmentation and thickness, appearance of trichohyaline granules) and the incorporation of tritiated thymidine into mouse skin from animals previously treated with either TE or V (skin organ culture). This inhibitory activity seemed to be localized to the epidermis and was also present in rat epidermis. We suggest that this apparently non‐speciesspecific inhibitor present in telogen skin may play a role in regulating the hair cycle in ro

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb06266.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

summarySixteen patients with localized scleroderma (LS) and 11 with progressive systemic sclerosis (PSS) were studied using non‐invasive techniques to determine skin thickness, skin extensibility, transcutaneous PO2and cutaneous blood flow and were compared with normal controls. LS was characterized by a decreased skin extensibility with thickening of the skin in progressive lesions. There was an increase in the cutaneous microcirculation with a decrease in the PO2. In PSS, there was a decrease in the skin extensibility caused by thickening of the skin, but no change in cutaneous microcirculation or PO2values. These results indicate that skin thickness and extensibility are the most useful parameters in the study of the progression of LS and PS

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb06267.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY