摘要:

Summary.—The term parapsoriasis en plaques includes 2 quite unrelated conditions, one eczematous and benign, the other prereticulotic and potentially malignant. These 2 conditions are described and their features are compared in detail. In England, especially the south, the benign form is a good deal more common than the premalignant. The reason why parapsoriasis en plaques is regarded as a potentially serious disease is thus due largely to nomenclature, but also in part to the fact that, in the early stages of the classical Alibert form of mycosis fungoides and in prereticulotic poikiloderma, the appearances can closely simulate the benign type of parapsoriasis. Careful clinical observation and histological examination should, however, serve to distinguish between the

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb01586.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—An unusual case of necrotizing vasculitis is reported, in which chronic bronchitis preceded the onset of “allergic” vasculitis of the skin, rhinitis, conjunctivitis, pulmonary infiltrates, marked blood eosinophilia and extra‐vascular granulomatous proliferation. The case had features of both Churg's allergic granulomatosis and Wegener's granulomatosis, but it was typical of neither condition. The relationship between benign pulmonary eosinophilia, Churg's allergic granulomatosis and Wegener's granulomatosis is discussed, and it is suggested that intermediate cases of this type might be called Chegener's granulomatosis. A review of the literature suggests that the range of syndromes could be extended to include Chöffler's pulmonary eosinophilia, comprising cases transitional between Löffler's and Churg's syndromes. For the sake of brevity and onomatopoeia the Löffler‐Chöffler‐Churg‐Chegener‐Wegener syndromes could be linked together as t

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb01587.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—The study egtailed bacteriological investigation of 131 cases of impetigo contagiosa, including the isolation and identification of the offending organisms. The data showed the presence ofStaphylococcus aureusin pure culture in 40.5% of the cases, and in mixed growth with betahaemolytic streptococci and other organisms in 47% of the cases. Streptococci came next in frequency and were isolated in pure culture from 9.1% of cases, and in combination with other organisms in 36.7% of the cases. A haemolytic diphtheroid having the characteristics ofCorynebacterium pyogeneswas isolated in pure culture from one case and in mixed growth in 5.3% of the case

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb01588.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—Eleven children have shown similar changes on the facial skin. A bright malar flush was accompanied at times by small superficial papules, pustules and scaling. The clinical picture was variable, sometimes closely resembling rosacea and sometimes peri‐oral dermatitis, taking an average of 1 year to clear.Seven of the 11 children had a family history of atopy, and 2 had a family history of rosacea. Potent topical corticosteroids may have played a role in the cause of these children's rash and, on withdrawal, there was sometimes a pustular exacerbation. The relationship to rosacea and peri‐oral dermatitis is disc

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb01589.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—Seventy‐three patients, 5 men and 68 women, suffering from perioral dermatitis have been seen in the last 2 years in the Rupert Hallam Department of Dermatology, Sheffield. All but 2 had used fluorinated steroids during the course of their illness. Substitution of hydrocortisone for the fluorinated steroid was followed by improvement in some, but the majority of patients required a course of oxytetracycline 250 mg twice daily for several months to produce complete recovery. A postal follow‐up of 20 patients who had discontinued treatment for 6–14 months gave 13 useful replies. Eleven patients had had no further skin eruption, one a mild recurrence, and one who had used betamethasone cream again, a severe recurrence.It is suggested that fluorinated steroid applications can alter banal skin inflammation of the face into perioral dermatitis and that such applications are contraindicated in the treatment of facial er

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb01590.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—Electron microscopy of oral epithelial plaque from patients with candidiasis confirms that the growth of candidas is intracellular and that the fine structure of the epithelial cytoplasm shows minimal change. The invading hyphae show well defined organelles, including a denticulate cytoplasmic membrane, nuclei, cristate mitochondria, rough and smooth endoplasmic reticulum, polyribosomes and storage granules. The fine double layer formation of the intra‐cytoplasmic membrane structures is clearly demonstrable when using osmium tetroxide as fixat

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb01591.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—The introduction into the skin of chemical substances or organic matter can produce granulomata of sarcoid type. A new granuloma of this type related to wounds produced by the stubble of wheat is described. The diagnosis of this lesion is easy, taking into consideration its localization in the lower limbs, the wounds caused by stubble, and the identification of intracellular plant material in the granuloma. A host factor of probable immunological nature is suggested. There is a similarity between these sarcoid granulomata of the skin and some epithelioid granulomatous lesions of the lung due to the inhalation of chemical substances and organic matter, known as “extrinsic allergic alveolit

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb01592.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—α‐ and β‐D‐glucosidases, β‐D‐glucuronidase, α‐ and β‐D‐mannosidases, α‐and β‐D‐glucosidases, β‐D‐fucosidase, α‐L‐fucosidase and β‐D‐Nacetyglucosaminidase activities were measured in the human epidermis using p‐nitrophenol and 4‐methylumbelliferone compounds as substrates. There was no appreciable difference in activities noted when both substrates were compared. Acid phosphatase was assayed with p‐nitrophenol phosphate and α‐naphthyl acid phosphate as substrates. Acid phosphatase seemed to be present, both free in the cytoplasm and in lysosomes. These 2 activities could not be differentiated by agarose electrophoresis (both fractions showed 2 anodally migrating bands).Some of the biochemical properties of these acid hy

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb01593.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—The3H‐Thymidine (3HT) nuclear labelling index of “round” cells of the dermal infiltrate in allergic and irritant patch test reactions in man has been compared. The skin of 15 positive allergic patch test reactions (to different allergens) and of 15 positive irritant reactions (5 to croton oil, 5 to potassium hydroxide and 5 to white spirit) was biopsied 48 hours after the application of the chemical. Thin slices of each specimen were incubated for 60 min in the presence of3HT. then fixed and prepared for light microscopy radioautography. Two thousand “round” cells of the infiltrate were counted in each specimen.The mean values of the3HT labelling indices (±S.E.) were 2·91±0·18%, in the allergic group and 0·58 ± 0·06% in the irritant group. The difference between the 2 means was highly significant (P0.05). All the labelled cells were mononucleated.This method could be useful to differentiate clinically dubious allergic and

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb01594.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—In 6 cases of pemphigus (4 pemphigus vulgaris, 1 pemphigus vegetans and 1 pemphigus erythematosus) the direct immunofluorescent method (DIF) revealed various complement factors, as there are Clq, C4 (β1E), β1A and α2D, localized in the intercellular spaces of the epidermis of the skin or mucosa immediately next to the bulla.Immunoglobulin and complement were shown together in the prickle cell layer of the epidermis, while complement staining alone usually could be shown in the intercellular spaces of basal cell layers and in the junctional zone.The possibility that antibody‐mediated complement deposition and/or alternate pathway activation may play a role in the underlying mechanism in pemphigus is dis

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb01595.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY