摘要:

SUMMARYBetween 1982 and 1986 we have had the chance to study 21 patients with pemphigus foliaceus of the ‘fogo selvagem’ type. The patients came from El Bagre and Nechi, rural areas of Colombia with some gold mining.This is the first outbreak of South American pemphigus foliaceus reported in Colombia.The majority of the patients were mestizo men, who worked as farmers or miners or both, with an average age of 44. Five patients were relatives. Eleven patients (52%) had mild disease, three (14%) moderate disease and seven (33%) severe disease. During hospitalization, three patients died due to complications or as a result of immunosuppressive treatment. Of the remaining 18 patients, 10 were in remission with treatment, one was in remission without treatment, while no information was available on the remaining se

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb02590.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYIn 101 patients with non‐familial cutaneous melanoma (CM), mlanocytic naevi were counted and classified according to clinical criteria. Only 8% of the patients had very atypical naevi. These atypical naevi were few in number and only one patient exhibited dysplastic naevus syndrome. An histological study was undertaken on the hypothesis that, in a given individual, if the most clinically atypical naevus is not histologically dysplastic it is unlikely that any of the others are. The most clinically atypical naevus in each patient was biopsied. Estimated in this way the prevalence of dysplastic naevi in patients with non‐familial CM was only 18%. Comparison of patients with and without dysplastic naevi did not suggest that they constituted two different subsets. An attempt to correlate clinical diagnosis and histologicai features in this group of patients showed that the diagnosis of dysplastic naevi on the basis of clinical criteria alone is difficult and not relia

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb02591.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYWe measured levels of creatine kinase and its three isoenzymes in serum and blister fluid from 16 healthy volunteers. The BB‐isoenzyme was found to be the predominant form in blister fluid white only the MM isoenzyme was found in serum. The levels of BB‐isoenzyme in blister fluid decreased as the blisters aged. The source of BB‐isoenzyme in blister fluid is most probably the damaged epid

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb02592.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYThe class I and class II HLA serologically defined antigens and DQα and DXα restriction fragment length polymorphism (RFLP) in 23 patients with linear IgA disease (LAD) were determined and their frequencies compared with those in a group of patients with dermatitis herpetiformis (DH) and healthy controls.In LAD there was a significant increase in HLA‐B8 and DR3 and a larger increase in the DQw1‐DR2/DRw6 related DQα 6.2 kb and 6.8 kb RFLP. In DH there was a significantly increased frequency of HLA‐A1, B8, DR3, and DQw2 with a concomitant increase in the DR3‐DQw2 related DQα 4.6 kb RFLP. The difference in DR3 frequencies and the increased frequency of DQw1 rather than DQw2 in LAD indicates that different susceptibility genes operate in the t

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb02593.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYCell surface carbohydrates arc thought to be important during embryonic development. We have studied a group of defined cell surface carbohydrates during the differentiation of fetal rat skin by the use of immunocytochemical techniques. We used monoclonal antibodies to the Le X and human blood group H type II haptens. The structure of the molecules carrying these haptens has been inferred by the sensitivity of the immune reactions to digestion by glycosyl hydrolases.The primitive ectoderm expressed the Le X hapten. The differentiatting epidermis carries the H type 11 antigen, but this was only detected following cleavage of a terminally modified portior of the carbohydrate containing linear poly‐N‐acetyl lactosamine chains. These carbohydrates on epidermal cells are carried N linked to glycoprote

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb02594.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYThe immune response to herpes simplex virus (HSV) was studied in 59 patients with primary and recrudescent facial HSV infections. The patients included nine with atopic eczema, seven of whom had eczema herpeticum (EH). All patients had antibodies to HSV (measured by ELISA) and all but three had HSV‐specific cell mediated immunity (CMI) (measured byin vitrolymphoproliferation). Thirteen control subjects were negative for both tests. All three patients with absent CMI to HSV had suffered from severe EH and had depressed CMI to HSV for several months following an attack. In two of these EH patients, a positive CMI response was produced by in vitro removal of CD8 + ve T lymphocytes from peripheral blood mononuclear cells using a panning technique. Thus the absence of CMI to HSV in these patients was due to suppressor cell function rather than a lack of specifically responsive cells. The other four EH patients with normal CMI to HSV had suffered less severe EH, but no association between the absence of CMI to HSV and serum IgE level or activity of the eczema was apparent in the atopic patients. No specific anti‐HSV IgE antibody was detecta

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb02595.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYThe effect of UVB therapy after short contact dithranol therapy (SCDT) was examined in 53 patients with psoriasis. After dithranol application, patients were randomly allocated to receive either a tar bath and UVB therapy (27 patients) or an emulsifying ointment bath only (26 patients). Forty eight patients completed the study; 16 of the 21 dithranol only patients cleared in a mean of 19.5 days compared with 20 of the 27 dithranol + UVB patients who cleared in a mean of 20.3 days. These differences were not significant. Similarly there was no significant difference in response between the dithranol only and dithranol UVB group as measured by the change in plaque thickness measured using Harpenden calipers, and the severity of psoriasis assessed by the extent of the rash, the degree of scaling, redness and induration. Thirteen of the 16 dithranot only patients who cleared relapsed in a mean of 10.6 weeks compared with 14 of the 20 dithranol UVB patients who relapsed after a mean of 18.9 weeks (P<0.05). Comparison of pre‐ and post‐treatment full blood count, biochemical screen and urinalysis showed no evidence of systemic toxicity due to SCDT. This study shows that UVB therapy does not improve the clearance of psoriasis in SCDT, but does significantly postpone rela

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb02596.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYFifteen adolescent children with severe, persistent atopic eczema were treated with oral psoralen photochemotherapy (PUVA). This resulted in initial clearance of eczema in 14 of the 15 children, nine of whom achieved a remission. Apart from its effectiveness, a major benefit of this therapeutic approach was that it was associated with resumption of normal growth in children who were previously growing poorly, either as a direct result of severe eczema or its treatment. Nevertheless, against the considerable advantages of PUVA for this group of patients have to be balanced the possible hazards, because relatively high exposures are required in some individuals, both initially to induce clearance and subsequently to maintain it.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb02597.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYThirty four per cent of 2110 patients with eczema attending a contact dermatitis clinic presented with hand eczema. An epidemiological comparison was made of patients with hand eczema and non‐hand eczema (defined as eczema on parts of the body other than the hands). Occupational eczema was significantly more common in the hand eczema than the non‐hand eczema group (P = o.ooII). The prevalence of atopy was the same in both groups (13%). The prevalence of irritant contact dermatitis was higher in the hand eczema group (32%) than the non‐hand eczema group (13%) (P<0.0001). The rate of allergic contact dermatitis was lower in the hand eczema group (23%) than the non‐hand eczema group (39%) (P<0.0001). The rate of positive patch test reactions was lower in the hand eczema group (41 %) than the non‐hand eczema group (56%) (P<0.0001). Nickel sulphate (8%), cobalt chloride (3%), potassium dichromate (3%), and fragrance mix (4%) were common allergens encountered in hand eczema group. None of these allergens was specifically more prevalent in the hand eczema than the non‐hand eczema group. However, the prevalence of allergy to nickel, colophony, epoxy resin and medicaments was significantly higher in the non‐hand

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb02598.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYThree objective measurements were made in 11 patients with facial port wine stains and in five controls. Laser Doppler flowmetry, reflectance spectrophotometry and skin surface temperature were all significantly elevated in the port wine stains compared with the normal contralateral cheeks and control skin (P<0.05).Changes in skin blood flow and temperature after local heating and cooling of the skin were similar at all sites assessed and were not associated with significant changes in reflectance spectrophotometry, the parameter which correlated most closely with skin colour.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb02599.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY