摘要:

SUMMARYSkin biopsies from four patients with lichen planus were studied using monoclonal antibodies directed against T lymphocytes. Anti‐T1 and anti‐T3 antibodies, which react with all peripheral T cells, stained most cells in the dermal infiltrates. The majority of infiltrating cells also stained with anti‐T4 and anti‐T4b antibodies, which react with helper/inducer cells, whereas a minority of cells stained with anti‐T8 antibody, which reacts with cytotoxic/suppres‐sor cells. Surface IgM was not identified on any infiltrating cells, providing evidence against B cell participation. Intraepidermal and dermal cells with long cytoplasmic extensions stained with anti‐T6 antibody in all cases, defining them as Langerhans cells or their precursors. T6‐positive cells were seen in greater number than in normal control epidermis and dermis. The results indicate that well‐developed lesions of lichen planus are characterized by an influx of helper/inducer T lymphocytes and increased numbers of Langerhans cells. These observations support the contention that cellular immunity is important in the pathogenesis

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb00970.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYVibrissa dermal papilla cells have been successfully grown and serially cultured and their early behaviour compared with cultured feather dermal papillae. Initially the vibrissa cells demonstrated singular characteristics, including poor spreading ability, before eventually forming a fibroblast‐like population of cell

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb00971.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYWe have shown that it is possible to produce a satisfactory clinical response with a low UV‐A dosage regime in approximately one‐third of patients with widespread chronic psoriasis. UV‐B phototherapy is as effective initially, but the improvement is not as well maintained as that resulting from photochemotherapy (PUVA). However, in view of the probability that unwanted side effects of PUVA are related to the amount of UV‐A irradiation administered, it would seem appropriate to restrict the use of the higher dosage regimes to selected patients and to those who have not responded to an initial low dosage regime or to UV‐B pho

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb00972.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYGuinea‐pigs previously sensitized to dinitrochlorobenzene (DNCB) were topically treated with 8‐methoxypsoralen solution and longwave ultraviolet light (PUVA). The animals showed moderate or no clinical and microscopic responses to an elicitation dose of DNCB given immediately after the period of treatment. Exposure to ultraviolet light or psoralen alone did not affect the allergic response. Ten days after PUVA treatment there was a normal eczematous reaction after application of D

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb00973.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYDirect immunofluorescence was performed on washed oral epithelial smears from thirteen patients with pemphigus vulgaris, thirteen patients with other oral diseases and from ten subjects with clinically healthy oral mucosa.The intercellular deposition of IgG was observed on cytological smears from oral lesions in all patients with active pemphigus. In contrast, smears from pemphigus patients in remission, from patients with other oral diseases and from healthy controls, did not show any fluorescence. Therefore, direct immunofluorescence on cytological smears may be of value in the diagnosis of pemphigus.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb00974.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYSera from forty‐six patients with dermatitis herpetiformis (DH) were examined for anti‐gliadin antibodies (AGA) by the enzyme linked immunosorbent assay (ELISA) test and by a simple new immunofluorescent (IF) test. AGA were present in fifteen out of thirty‐two patients taking a normal diet, but in none of the fourteen taking a gluten‐free diet (GFD). The presence of circulating AGA was related to the severity of the enteropathy. AGA were present in all ten patients with a flat mucosa and in four of six with a convoluted mucosa, but in only one out of thirty patients with normal morphology of the small intestine. However, in those patients taking a normal diet and with a normal morphology of the intestine there was evidence of gluten sensitivity compared to those taking a GFD, as the intraepithelial lymphocyte count (IELC) was significantly raised in the peri‐nuclear and supra‐nuclear positions. The study shows that the presence of AGA in the serum is a good indication of the degree of gluten sensitivity as expressed by severe mucosal damage in patie

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb00975.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYCirculating vitamin A is transported by a carrier termed retinol binding protein (RBP). Autoradiography and immunofluorescence studies showed that, in normal human skin, RBP is confined exclusively to the dermis. Following oral vitamin A loading, a large increase in dermal RBP but only a very small rise of serum RBP was found.Serum RBP was slightly decreased in eczema patients and markedly decreased in patients with porphyria cutanea tarda. Values in other dermatoses, including psoriasis, were normal.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb00976.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYThe dynamics of intraepidermal penetration of the scabies mite and the host's responses to the invaders have been studied in hyperkeratotic scabies.Contrary to the generally accepted view, the mites progressed not only through the stratum corneum but also into the underlying epidermis and even occasionally to the dermo‐epidermal interface. Morphological evidence of reactive processes included parakeratosis surrounding the burrows, psoriasiform hyperplasia with increased basal cell labelling indices and exocytosis of mononuclear cells.3H‐Thymidine labelling indices of immunocompetent cells of the dermal infiltrate reached levels found in allergic patch test reactions and were in both cases higher than in non‐immune‐specific inflammatory processes. The labelling index of peripheral blood lymphocytes showed an increased ratio of B cells to T cells as compared to controls or patients with allergic contact dermatitis. Serum C1q fixation was higher than in untreated patients with common scabies.These results support our previous findings of immunological activation in hosts infested by the scabi

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb00977.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYThe fibrinolytic activity of normal human oral epithelium and abdominal epidermis was studied by two techniques. With fibrinolytic autography, dorsal tongue, ventral tongue, cheek, palate and gingival sulcus epithelium showed fibrinolytic activity but oral gingival epithelium and the epidermis showed no activity. With a fibrin plate technique, potassium thiocyanate extracts of epidermis and oral epithelium all showed strong fibrinolytic activity, but activity in tris buffer extracts was demonstrable only with oral epithelium, and the activity was much weaker. The fact that the tris buffer extractable fibrinolytic activator was demonstrated only in oral epithelium suggests that the presence of this activator in epithelium is related to the type of keratinization and/or its rate of cell turnover.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb00978.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYWe determined by trichometry the rate of hair growth in ten hirsute patients receiving a combination of cyproterone acetate (CA) 50 mg/daily and ‘Diane‘® (CA 2 mg + ethinyl oestradiol 0·05 mg). In two patients there was a prompt and persistent reduction in hair growth; in three the response was less marked, and in the remaining five patients the rate of hair growth fluctuated during therapy. However, there was an overall reduction in hair growth in all but one patient during the 12 months of treatment and all patients noticed that their hair became softer, thinner and lighter in c

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1981.tb00979.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY