摘要:

SUMMARYNaevus superficialis lipomatosus (NSL) is a rare malformation consisting of multiple or solitary papules usually occurring on the lower trunk or gluteal regions. In this study the clinical features of twenty new cases are described with a detailed account of the histopathology. Notable were the marked variability in the amount of ectopic fat found in the lesions, and the presence of associated abnormalities of the connective tissue, the vessels, and the skin appendages. In early lesions, mononuclear cells differentiating into lipoblasts could be identified around proliferating capillaries.Two clinical types were distinguished. First, the classical type (7 cases) consisting of multiple lesions occurring in a zonal distribution, and secondly the solitary papule or nodule (13 cases). The latter type can be difficult to distinguish from a skin tag with fatty herniation.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb06731.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYIn 131 patients with chronic urticaria, including physical urticarias, oral provocation tests were done with aspirin. A total of thirty‐one patients showed a reaction on aspirin challenge. Reactions were seen in 35% of patients with idiopathic urticaria, 52% of patients with cholinergic urticaria, and 43% of those with pressure urticaria.The patients with reactions to aspirin were also tested with tartrazine, sodium benzoate, 4‐hydroxy benzoic acid, sodium‐ and phenyl salicylate and the analgesics indomethacin, paracetamol and mefenamic acid. In nineteen of twenty three aspirin sensitive patients, positive reactions to one or more of these substances were observed. Indomethacin and tartrazine had the highest scores. There was no statistically significant correlation between aspirin reactions and the presence of nasal polyposis, sinusitis, asthma or

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb06732.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYThe cutaneous sensitivity to benzalkonium chloride, sodium lauryl sulphate and potash soap was determined in 54 monozygotic and 46 dizygotic twin pairs. Comparing the intra‐pair reaction strength a higher degree of concordance was found among monozygotic than among dizygotic twins, and even more so when monozygotic twins were compared with matched control

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb06733.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYThe importance of physically intact hands and feet is taken for granted and consequently not appreciated until they are functionally impaired by vascular or neural injury or disease. The pathogenesis and clinical manifestations of cutaneous lesions complicating hypersensitive and insensitive limbs are described. The current therapeutic approaches and measures for these conditions are presented. Protection and prophylaxis against precipitating trauma for neurologically impaired parts are emphasized.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb06734.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYThe water content of human stratum corneum has been measured gravimetricallyin vitroin relation to relative humidity (RH) and temperature. Water content increased with increasing RH. Stratum corneum water content increased 50% when the temperature was raised from 20 to 35°C at RH below 60%. Temperature dependence decreased with increasing RH until there was essentially no temperature dependence at 90% RH. The conclusion is that temperature changes could significantly affect water contentin vivoand pliability of skin at RH below 60%

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb06735.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYIntraendothelial tubular aggregates were found in small dermal blood vessels in three healing superficial wounds in patients receiving systemic corticosteroids. Similar inclusions were also demonstrated in two wounds in healthy subjects, but were not found in normal (unwounded) skin of either healthy subjects or steroid‐treated patients.Tubular aggregates of similar structure have previously been described as occurring in ‘connective tissue’ or ‘auto‐immune’ diseases, including lupus erythematosus and dermatomyositis, both in the skin and in internal organs.Although it has been suggested that such aggregates are of viral origin, their morphogenesis and significance remain undetermined. Our findings do not support a viral cause, but suggest that these structures are probably a product of regenerating

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb06736.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYIn the course of evaluating the effect of different drugs on the morphology ofMycobacterium leprae(Edwards, Draper&Draper, 1972) and on the phagocytic cells containing these organisms (Edwards, 1973), an unusual feature was observed in the dermal connective tissue of skin biopsies obtained from some of the patients. Variable amounts of an extracellular, cross‐striated osmiophilic material were present in the dermis.The purpose of this communication is to describe the banded substance observed in the extracellular space of the lepromatous skin and to compare it briefly with similar substances and structures reported to occur elsewher

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb06737.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYThree patients with extensive skin disease and liver failure are described. Two were treated with large amounts of topical corticosteroids and one with a small oral dose of betamethasone. The former two patients developed Addisonian crises when they failed to apply the topical steroids and all three patients developed aseptic necrosis of bone. This report emphasizes that the hazards of steroid therapy may be increased in patients with hepatic failure.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb06738.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYThe determination of nickel by instrumental neutron activation analysis is presented. The58Ni (n, p)58Co reaction and high‐resolution gamma spectroscopy were employed in these measurements. The nickel content of human hair was found to be more dependent upon the sex of the donor than upon other parameters. Mean values for males (1·01±0·23 ppm) and females (4·21±0·54 ppm) agreed with values for the nickel content of hair obtained by other methods in most cases. Nickel sensitivity was not reflected in the nickel contents of hair in the

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb06739.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYThe relative importance of the environment versus the physiology of the host in the control of Gram negative bacteria on skin has been examined by two experimental designs.(1) The changes in incidence of Gram negative carriage from three skin sites in a climate controlled chamber at 35° C and 90% humidity for 64 h were determined. Following 2 weeks of tetracycline treatment the above experiment was repeated. High temperatures and humidity increased the overall frequency of isolation of Gram negative bacteria although there were individual differences. This effect was reversed 24 h after a return to the natural environment. Tetracycline inhibited the increase in isolation of Gram negative organisms in six subjects, enhanced it in three and had no effect on one subject. Gram negative populations were less than 10 colony forming units/cm2of skin in most instances but ranged up to 10,000/cm2skin. No residual effect occurred after return to natural environment and at no time was there a loss of normal flora.(2)Klebsiella pneumnoniae, Proteus vulgarisandPseudomonas aeruginosawere inoculated on normal skin of ten volunteers and survival determined during a 24 h period. Viability was lost between 2 and 6 h on most subjects as compared to 24 h or longer forK. PneumoniaeandP. vulgarison an inert surface and between 8 and 24 h forPs, aeruginosa.It was concluded that extremes of environment can affect Gram negative skin carriage but under normal conditions in healthy individuals there is evidence of physiological control of Gram negative flora

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb06740.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY