摘要:

AbstractFree amino acids were measured with a microtechnique employing labelling with14C‐dansyl‐Cl and separation with two‐dimensional thin‐layer chromatography. Most amino acids occurred in greater amounts in the islets than in the exocrine pancreas. Aspartic acid, valine and leucine were present in tenfold amounts. It is postulated that the β‐cells are equipped with binding sites for large amounts of the latter amino acid. Like nervous tissue, the pancreatic islets were characterized by the presence of gamma‐aminobutyric acid and high level

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1972.tb05175.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

AbstractMale albino mice were injected with3H‐atropine and killed 5 min, 30 min and 2 h after the injection. The distribution of radioactivity in the pancreas and the thyroid was then studied with a microautoradiographic technique for isotopes in water soluble form. In the pancreas the highest radioactivity was found in the pancreatic islets. In the thyroid the radioactivity was most strongly accumulated in cells with a distribution corresponding to the parafollicular cells. A method for a combination of monoamine fluorescence with microautoradiography was also used to show that the cells of the pancreatic islets and the parafollicular cells of the thyroid, which are capable of monoamine accumulation after monoamine‐precursor injection, also are capable to accumulate atrop

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1972.tb05176.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

AbstractThe Po2in the vitreous body close to the retina, PvrO2, was determined continuously with an O2electrode. In cats with a mean arterial blood pressure of 176±7 cm H2O, a PaO2of 98±2 mm Hg, a PaC02of 27.0±1–2 mm Hg and a pH of 7.43±0.16 units the mean PVr02 was 18.9±1.5 mm Hg. Stepwise increments in the eye pressure had no effect on PVrO2at perfusion pressures above 50–100cmH2O. At lower perfusion pressures PvrO2decreased. Changes in perfusion pressure caused by hemorrhage and retransfusion gave similar results. At low Paco2levels PvrO2decreased; at high PaCo2levels values of 40–60 mm Hg were observed. Reductions in Pao2decreased Pvro2, increments gave either no change or a rise in Pvr02‐ Hypercapnia combined with high Pao2in several cases resulted in PVr02values between 100 and 150 mm Hg. The results indicate that the blood flow through the retina is very efficiently autoregulated, that oxygen tends to induce vasoconstriction in the retinal blood vessels, that hypocapnia gives vasoconstriction and hypercapnia marked va

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1972.tb05177.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

AbstractBagger, H.The distribution of Xe‐133 in the left and right ventricular walls of dog hearts after left ventricular bolus injection.Acta physiol. scand. 1972.84.275– 283.Regional coronary blood flow was estimated in dogs by counting the activity in tissue blocks of the left and right ventricular walls after bolus injection of Xe‐133 into the left ventricular cavity.Myocardial uptake of the isotope was 1.7 times higher in the left than in the right ventricular wall, while comparison of the activities in the subepicardial half of the walls showed a ratio left/right of 1.5.The transportthroughthe endocardialsurfaceof the left ventricular wall was measured during constriction of the left coronary artery. Xe‐133 penetrates to a depth of 7 mm, indicating that transport across the endocardial surface might contribute to the activity of the subendocardial half of the wall.In the left ventricle the activity was higher (15 %) in the subendo‐ than subepicardial half of the wall, but in view of the transport across the endocardial surface, the amounts of xenon transported by the coronary arteries seem to be equal, indicating a uniform perfusion of the left ventricular wall. No differences appeared either between areas supplied by the anterior descending and circumflex branches of the left coronary artery or between the apex and the base.In the right ventricular wall there was no difference between subepi‐ and subendocardi

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1972.tb05178.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

AbstractBranemark, P.‐I. and E. Eriksson.Method for studying qualitative and quantitative changes of blood flow in skeletal muscle.Acta physiol. scand. 1972.84.284–288.A vital microscopic method for studying changes of blood flow in skeletal muscle has been devised. The tenuissimus muscle of cat and rabbit was dissected and arranged for direct microscopic observation. Simultaneous measurements were made of central blood pressure, pulse, pulse pressure and regional blood flow as well as of the diameters and flow rates of the vessels with a diameter of 2μ–100μ.Hematological phenomena and changes in blood cell rheology could also be registered. This method will be used for studying the function of the resistance vessels and the effects on the microcirculation of hemorrhagi

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1972.tb05179.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY