摘要:

Summary.In order to test the erythropoietic activity of saline in which blood cells were suspended during low pressure exposure the following experiments were performed.1. Six rabbits had intraperitoneal injections of 2—5 ml of “anoxic saline”. The injection was followed by an increase in the number of red cells on the 4 first days. (Average increase on 3—4 days 0.42 ± 0.14 millions/μl.)2. Eight rabbits were given intravenously 7—15 ml of “anoxic saline”. The animals reacted to the injection with an increase in the erythrocyte count which was of a smaller magnitude than in the previous group. (Average increase on 2—3 days 0.20 ± 0.07 millions/μl.)3. Eight control rabbits had intravenous injections of saline in which blood cells were suspended under normal pressure. In this group the injection was followed by a moderate decrease in the erythrocyte count. The difference between the reactions in the second and third groups is statistically significant (difference on the 3rd day 0.47 ± 0.15 millions/μl).4. Three rabbits had intravenous injections of saline in which cells from anoxic blood were suspended for 20 minutes. The injection was followed by an increase in the erythrocyte count of a similar ma

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1958.tb01562.x

出版商:Blackwell Publishing Ltd    

年代:1958

数据来源: WILEY

摘要:

Summary.1. The outside of the isolated frog skin in the absence of penetrating anions behaves over a wide range of concentrations as a sodium electrode, while the inward‐facing surface behaves like a potassium electrode.2. A theory concerning the origin of the frog skin potential is put forward based on these observations and the assumption that the active transport of sodium is located at the inward‐facing membrane of the epithelial cells.3. Reasons are given for the hypothesis that the active transport of sodium in reality is a forced exchange of sodium against potass

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1958.tb01563.x

出版商:Blackwell Publishing Ltd    

年代:1958

数据来源: WILEY

摘要:

SummaryThe adrenaline and noradrenaline content has been determined in the kidneys and in the spleen of the cat with and without preganglionic denervation, effected by splanchnicotomy on the left side. No significant difference was observed between the catechol amine values in the control organs and after decentralization. It is concluded that the preganglionic sympathetic fibres do not exert an influence on the noradrenaline content in the postganglionic nerve fibres nor on the adrenaline content of the organ. The postganglionic neurones are in this way similar to the chromaffin cells. The results further suggest that the splanchnic nerve does not supply postganglionic fibres to the spleen and the kidney.

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1958.tb01564.x

出版商:Blackwell Publishing Ltd    

年代:1958

数据来源: WILEY

摘要:

Summary.On stimulation of autonomic areas of the cerebral cortex selective changes in the adrenaline secretion from the adrenal medulla can be obtained. Most consistently an inhibition of the adrenaline secretion is obtained on stimulation of structures in ventral parts of the cerebral cortex, while the noradrenaline secretion is only little affected.

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1958.tb01565.x

出版商:Blackwell Publishing Ltd    

年代:1958

数据来源: WILEY

摘要:

Summary.1. The catechol amine containing granules of the cow adrenal medulla have been isolated as a fraction of high purity by density gradient centrifugation. They have a very high content of amines (34.3 μmoles/mg protein‐N) and ATP (7.6 μmoles). Smaller amounts of ADP (0.89 μmoles), AMP (0.27 μmoles) and inorganic phosphate (1.45 μmoles) are also present. The adenosinephosphates represent at least 95 per cent of the acid soluble organic phosphates in the granules.2. The molar ratio amines: ATP is 4.5: 1 or 3.9: 1, if the ADP and AMP in the granules are assumed to be split products from ATP. The sum of adenosinephosphates and inorganic phosphate represents an amount of acid equivalent to the catechol amines. This suggests that the amines are stored in intimate relation to the phosphates.3. The osmotic properties of the granules and the amine content found in them make it necessary to assume that the amines are incorporated, together with the adenosinephosphates, in a complex molecular structure which prevents them from forming free ions or molecules in the intragranular water. The presence of large amounts of water soluble proteins (77—78 per cent of the total proteins) within the granules suggests that these proteins are a component in the postulated s

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1958.tb01566.x

出版商:Blackwell Publishing Ltd    

年代:1958

数据来源: WILEY

摘要:

Summary.1. Bovine splenic arteries and veins contain about 0.3—0.4 μg noradrenaline per g indicating that also the veins have an important supply of adrenergic vasomotor nerves.2. Bovine pulmonary vessels with a diameter of 2 mm and above (“large vessels”) contain similar amounts of catechol amines as the splenic vessels; lung vessels and other vessels from dog show even higher figures.3. “Large” bovine lung vessels contain some 10 times more noradrenaline than peripheral lung tissue. This implies that while the larger pulmonary vessels are amply supplied with adrenergic‐vasomotor fibres, the small lung vessels are poorly innervated with adrenergic vasomotor fibres.4. Chromatographic separation of catechol substances in splenic and pulmonary vessels has indicated the presence of dihydroxyphenyl acetic acid, dihydroxymandelic acid, dopamine and noradrenaline in amounts which are similar for the two kinds of vessels but differ greatly from the relative and absolute amounts found in

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1958.tb01567.x

出版商:Blackwell Publishing Ltd    

年代:1958

数据来源: WILEY

摘要:

Summary.1. The thalamic relay nucleus in the specific sensory path from the tongue was localized in the medial part of nucleus ventralis posteromedialis of the cat.2. The center of the nucleus was found within a region defined by the following Horsley‐Clarke coordinates: frontally, 9 to 10, laterally, 4 to 5 and dorso‐ventrally, 0 to 1.3. The focal potential evoked by electrical stimulation of the tongue was recorded with microelectrodes in 0.25 mm steps along tracks through the thalamus of encéphale isolé preparations. The potential was evoked within a well localized region not exceeding 2 mm in diameter. The overlap with the nearby region of nucleus ventralis posteromedialis containing the tactile face relays was of the order of 0.2 mm.4. Responses to tactile, thermal and gustatory stimulation of the tongue were observed within the thalamic relay nu

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1958.tb01568.x

出版商:Blackwell Publishing Ltd    

年代:1958

数据来源: WILEY

摘要:

Summary.Oxygen consumption at graded temperatures was measured for crayfish, frog, newt and earthworm. In contrast to recent claims, these animals showed the normal metabolic response to rising temperature, with a Q10value of 2—3.So far the evidence for diurnal or other short term temperature compensation is at best poorly reproducible and the phenomenon can hardly be accepted as well establishe

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1958.tb01569.x

出版商:Blackwell Publishing Ltd    

年代:1958

数据来源: WILEY

摘要:

Zusammenfassung.1. Die von Pattersonund Mastinan der Ratte beobachtete blutdrucksteigernde Wirkung von intravenös injizierter Dehydroascorbinsäure (DHA) in Dosen von mehr als 5 mg/kg konnte auch an der Katze und am Meerschweinchen nachgewiesen verden.2. Der nach Halsmarksdurchschneidung und synaptischer Unterbrechung der sympatischen Nervenbahnen durch Ganglienblocker beobachtete, wenn auch stark verminderte Blutdruckanstieg und die positiv chronotropen und inotropen Veränderungen der Herzaktivität nach intravenösen Injektionen von Dehydroascorbinsäure weisen jedoch auf einen zweiten, peripheren Aktionsbereich dieser Substanz hin.Summary.1. The findings of Pattersonand Mastinthat dehydroascorbic acid (DHA) injected intravenously in rats in doses higher than 5 mg per kg produces an increase in blood pressure, chiefly by central sympathetic stimulation, has been confirmed on cats and guinea pigs.2. Some increase in blood pressure and of heart activity were still observed after intravenous injections of DHA after chordotomy and synaptic interruption of sympathetic nerve conduction by ganglionic blocking agents, indicating a second peripheral mech

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1958.tb01570.x

出版商:Blackwell Publishing Ltd    

年代:1958

数据来源: WILEY

摘要:

Summary.1. The urinary excretion of noradrenaline and adrenaline was determined in normal rats and rats receiving dibenzyline. The effect of this blocking agent on the catechol content of the adrenals, heart and spleen was also observed.2. Dibenzyline caused an increased excretion of noradrenaline, and a decreased organ content of catechols. Urinary adrenaline remained unchanged.3. The significance of these findings is discussed in the light of the effector catechol receptor theory. It is suggested that dibenzyline may interfere with the metabolism of catechols in areas not contiguous to their site of production.

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1958.tb01571.x

出版商:Blackwell Publishing Ltd    

年代:1958

数据来源: WILEY