摘要:

Summary.Superposition of sinusoidal pulsations upon a steady mean pressure in the isolated carotid sinus has no influence on the blood pressure.

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1942.tb01436.x

出版商:Blackwell Publishing Ltd    

年代:1942

数据来源: WILEY

摘要:

Zusammenfassung.Mit Hilfe der beschriebenen Versuchsanordnungen sind die folgenden Beobachtungen an Atmungsreflexen bei endosinualen Druckvariationen bei der Katze gemacht worden:1) Endosinuale Druckänderungen brauchen keinerlei Veränderung der Atmung herbeizuführen, selbst wenn typische Blutdrucksreflexe auftreten.2) Unter gewissen Bedingungen können endosinuale Druckänderungen Atmungsvariationen herbeiführen, auch wenn keine Blutdrucksreflexe auslösbar sind.3) Die obengenannten Versuchsergebnisse liefern keine Stütze für die Annahme, dass Atmungsreaktionen bei endosinualen Druckänderungen bei der Katze über die Barorezeptoren unter normalen Bedingungen erfolgen, sondern stehen vielmehr im Einklang mit der Auffassung, dass die Atmungsveränderungen über die Chemorezeptore

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1942.tb01437.x

出版商:Blackwell Publishing Ltd    

年代:1942

数据来源: WILEY

摘要:

Summary.1. The electroneurogram of the dog's carotid sinus nerve reveals a train of potentials of various sizes forming compact volleys at each systole. All the larger and medium‐sized potentials derive from baroceptive fibres.2. Apart from the larger potentials, there appears an electrical activity built up by axone potentials of very small spike‐heights in response to both chemical stimuli and intrasinusal pressure.3. Evidence is presented to show that these small axone potentials derive from two functionally different kinds of fibres, one kind specifically reacting to intrasinusal pressure, the other kind responding to chemical stimuli.The expenses of this investigation have been defrayed by grants from the Therese and Johan Andersson Memorial Foundat

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1942.tb01438.x

出版商:Blackwell Publishing Ltd    

年代:1942

数据来源: WILEY

摘要:

Zusammenfassung.1. Allgemeine Blutdrucksteigerung durch Blutinfusion verminderte die Atmungsamplitude bei unveränderter oder erhöhter Frequenz am chloralosierten Hund (Inspirationshemmung).2. Nach Durchtrennung der Vago‐Depressoren wurde diese Wirkung vermisst. Bei mittleren Ausgangsdrucken und Sauerstoffatmung trat eine mässige Frequenzminderung bei Druck‐steigerung zutage, die bei Luftatmung oder bei niedrigen Ausgangsdrucken, wo die Atmung von vornherein erhöht war, verstärkt wurde (Entlastung der Chemorezeptoren).3. Lokale endosinuale Druckerhöhung rief bei erhaltenen Vago‐Depressoren keine Atmungshemmung hervor, auch nicht bei konstant gehaltenem Blutdruck. Meist wurde eine leichte Frequenzzunahme beobachtet.4. Lokale endosinuale Druckerhöhung nach Durchtrennung der Vago‐Depressoren rief regelmässig eine Frequenzminderung hervor, auch bei konstant gehaltenem Blutdruck.5. Die Versuchsergebnisse haben keine Anhaltspunkte dafür gegeben, dass unter normalen Bedingungen die Atmung von den Barorezeptoren im Aorta‐ und Sinusgebiet reflektorisch beeinflusst wird, wie dies nach Durchtrennung der Vago‐Depressoren der Fall ist.Diese Untersuchung wurde aus Mitteln der Stiftung »Therese och Johan Andersso

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1942.tb01439.x

出版商:Blackwell Publishing Ltd    

年代:1942

数据来源: WILEY

摘要:

Summary.When oxygen was substituted for air in anesthetized cats or dogs, an almost instantaneous, sometimes very considerable, reduction of respiratory rate and amplitude occurred. This effect was abolished by denervation of both sinuses and was due to the disappearance of a slight oxygen want which stimulated the chemoreceptors of the carotid body. After some minutes of oxygen breathing the ventilation again closely approximated to the value from air breathing. This compensation is partly explained by an increased carbon dioxide tension, but a greater excitability of the center may also occur.Oxygen inhalation under the same conditions usually caused a fall in arterial blood pressure, amounting on an average to 2.2 per cent in the cat. After denervation of both sinuses and section of the vagodepressor nerves, oxygen inhalation led to an increased blood pressure. It is assumed that the first effect is due to the abolition by oxygen of the normal stimulation of the chemoreceptors, whereas the second effect is caused by the relief of a central depression, caused by hypoxia.The pulse rate also decreased, on an average 3.3 per cent in the cat, during oxygen inhalation. Most of the effect was abolished by section of the vagodepressor nerves and denervation of the sinuses.The expenses of this investigation have been defrayed by a grant from the Therese and Johan Andersson Memorial Foundation.

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1942.tb01440.x

出版商:Blackwell Publishing Ltd    

年代:1942

数据来源: WILEY

摘要:

Summary.1. The precipitation limits for fibrinogen have been studied under various conditions.2. The purification of fibrinogen solutions has been investigated and a method for the preparation of a purified prothrombin‐free fibrinogen solution from ox plasma is described.3. The measurement of thrombin by employment of ammonium sulphate precipitated fibrinogen has been described. Mellanby fibrinogen is unsuitable for measuring of thrombin.4. Fibrinogen shows rather high solubility in half‐saturated sodium chloride.This work was aided by grants from “Danmarks tekniske Højskoles Fond for teknisk Kemi” and from “Løvens kemiske Fabrik

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1942.tb01441.x

出版商:Blackwell Publishing Ltd    

年代:1942

数据来源: WILEY

摘要:

Summary.1. The action of sympatol and ephedrine on the isolated small intestine of the rat and the influence by previous addition of ergotamine on this action have been studied.2. Sympatol inhibits the intestine in cone. 60–120 γ/ml, ephedrine in cone, higher than 1,000 γ/ml. In cone, less than 1,000 γ/ml ephedrine in some cases stimulates the intestine.3. Previous addition of ergotamine does not affect the inhibiting action of sympatol and ephedrine.4. It is concluded that the inhibiting action of sympatol and ephedrine on the isolated small intestine of the rat is due to direct muscular depres

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1942.tb01442.x

出版商:Blackwell Publishing Ltd    

年代:1942

数据来源: WILEY

摘要:

Summary.1. The inhibiting action of adrenaline, adrenalone, arterenol, l‐adrianol and l‐corbasil on isolated rabbit's small intestine is diminished or abolished by previous addition of yohimbine or hydrastinine in sufficient doses.2. Previous addition of yohimbine or hydrastinine even in maximal doses in no way diminishes the inhibiting action of l‐, d‐ and dl‐ephedrine, l‐ and dl‐sympatol, suprifen, veritol and benzedrine. In contrariety hydrastinine sometimes intensifies the action of these drugs.3. Thus, the classification of adrenaline‐like drugs as to the influence of sympathicolytic drugs on their inhibiting action on isolated rabbit's intestine, which have been made previously on the basis of experiments with bee venom and ergotamine, is valid for yohimbine and hy

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1942.tb01443.x

出版商:Blackwell Publishing Ltd    

年代:1942

数据来源: WILEY

摘要:

Summary.1. In albino rats living in sexual abstinence the appearance of infected scratches is a common lesion.2. This affection is not seen in rats living a normal sexual life.3. The affection is cured when the animals are given the chance of a normal sexual life.4. The lifetime for unpaired rats is found to be considerably lower than the normal lifetime of the rat as given in numerous reports in the literature.5. It is reasonable, therefore, to assume that inhibition of the normal sexual function lowers the resistance of the animals to infection, resulting in a shorter lifetime.

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1942.tb01444.x

出版商:Blackwell Publishing Ltd    

年代:1942

数据来源: WILEY