摘要:

AbstractDiamant, B. and B. Fredholm.Effect of glucose and sodium succinate on oxygen uptake and histamine release in rat and guinea‐pig lung tissue in vitro. Acta physiol. scand. 1963. 59. 193–198.—Previous reports on the effect of sodium succinate and glucose on histamine release and oxygen uptake in guinea‐pig and rat lung tissue have been somewhat conflicting, and difficult to interpret. The present study was undertaken to determine whether the effect of the aforementioned substrates on histamine release could be correlated to their effect on the oxygen uptake. The results have shown that such a correlation exists in some but not all of the reactions investigated. The hazards of interpreting correlations between oxygen uptake and histamine release in lung tissue are poin

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1963.tb02736.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

摘要:

AbstractBuchthal, F. and L. Engbæek,Refractory Period and conduclion velocity of the striated muscle fibre. Acta physiol. scand. 1963.59. 199–220. —Refractory period and conduction velocity of transmembrane potentials were determined in single frog muscle fibres by intracellular stimulation and recording at 14, 20 and 25° C. At the end of the absolutely refractory period the latency of the potential evoked by the second stimulus was substantially increased mainly due to a reduction in conduction velocity, delayed firing causing at most 10 per cent of the total delay. The absolutely refractory period terminated at the onset of the negative after potential, recovery in excitability, amplitude and conduction velocity in the relatively refractory period occurred within a time interval in which the membrane potential did not change more than about 3 mV. At 2–3 times the absolutely refractory period excitability and conduction velocity had a supernormal phase. At the absolutely refractory period the level of depolarization required to initiate a propagated response had increased from 40 to more than 60 mV (recorded 0.25–0.6 mm from the stimulating electrode). A local response appeared at a time interval of 70–80 per cent of the absolutely refractory period of the propagat

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1963.tb02737.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

摘要:

AbstractSteen, JohanB.The physiology of the swimbladder of the eel, Anguilla vulgaris. III. The mechanism of gas secretion. Acta physiol. scand. 1963.59. 221–241. — The mechanism of gas secretion has been investigated by analysis of blood samples from arteries and veins at both poles of thereteassociated with the gas gland. During gas deposition, as measured by gas analyses of the bladder content, the blood is enriched in lactic acid as it circulates in the bladder epithelium. The pH of this blood is about 1 pH unit lower than that in the blood entering theretefrom the gills. Part of the lactic acid diffuses from venous to arterial capillaries in therete. A gradient in gas tension across thereteis produced partly by the existing acid gradient, and partly by the delayed response of the gas tension to the change in acid content which the blood undergoes as it passes therete. The results strongly support the theory that gas concentration occurs by a counter current multiplication in thereteof a primary gradient induced by the addition of acid electrolytes to the venous blood. The measured values on acid content, pH and blood flow agree very well with the values which have been found adequate, through calculations on the potentialities of such systems, to produce gas pressures higher than those actually measured, and it is concluded that this secretory mechanism will explain secretion of all the atmospheric gases even in deep sea fis

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1963.tb02738.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

摘要:

AbstractHäggendal, J.An improved method for fluorimetric determination of small amounts of adrenaline and noradrenaline in plasma and tissues. Acta physiol. scand. 1963.59. 242–254. — By the introduction of several modifications of the trihydroxyindole method for the determination of adrenaline and noradrenaline appreciable improvement of the sensitivity has been obtained. The blank values have been considerably reduced and stabilized by substituting dimercaptopropanol (BAL) in sodium sulfite solution for ascorbic acid. The eluate volume has been reduced and the degree of purification has been increased by a modified ion‐exchange procedure (Dowex 50 W‐X8). Deproteinization of plasma before the column procedure could be omitted. When this procedure was applied to 10 ml plasma obtained from normal persons at rest, noradrenaline spectra, with two activation peaks, were usually obtained. The average concentration of the noradrenaline was 0.3 ± 0.11 μgper litre of plasma. Normally no adrenaline was found. Noradrenaline occurred in plasma in both free and conju

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1963.tb02739.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

摘要:

AbstractHäggendal, J.The presence of conjugated adrenaline and noradrenaline in human blood plasma. Acta physiol. scand. 1963.59. 255–260. –The presence of conjugated adrenaline and noradrenaline in blood plasma is shown. As a rule 2 to 3 times more conjugated than free noradrenaline was found. When the free noradrenaline and adrenaline plasma levels were increased during muscular work and during insulin hypoglycemia, respectively, the levels of conjugated cate‐cholamines did not markedly change. After the oral administration of 5 mg adrenaline to a healthy man high amounts of conjugated adrenaline was found in the plasma and in the

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1963.tb02740.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

摘要:

AbstractHaggendal, J.The presence of 3‐0‐methylated noradrenaline (normetanephrine) in normal brain tissue. Acta physiol. scand. 1963.59. 261–268. — In the brain of normal pigs and rabbits normetanephrine was found in amounts corresponding to about 15 per cent of the noradrenaline values. After reserpine and after a catechol‐0‐methyl transferase inhibitor the levels of normetanephrine and of methoxytyramine were strongly reduced while initially the levels of noradrenaline and dopamine were normal. In extracts from the hypothalamus of man normetanephrine was also found. O‐methy‐lation seems to be an important pathway in the normal metabolism of noradre

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1963.tb02741.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

摘要:

AbstractGale, C. C.Non‐essential role of prolactin in the hormonal restoration of lactation in goats with radio frequency hypothalamic lesions. Acta physiol. scand. 1963.59. 269–283.–Coagulation of the median eminence by radio frequency heating in three of four lactating goats caused an abrupt onset of diabetes insipidus and a decline in milk production to 15 to 30 per cent of pre‐lesion levels. One goat with unilateral injury in the median eminence developed diabetes insipidus briefly but showed little block of lactation. In goats with depressed lactation, the administration of ACTH, STH, T3, and insulin restored milk production to, or above, pre‐lesion levels. Since no deficiency in secretion of prolactin could be demonstrated in goats with hypothalamic regulation interrupted by median eminence lesions, these data are in accord with the hypothesis that prolactin secretion is controlled by a central inhibitory mechanism. Diabetes insipidus developing after RF lesions was characterized by an abrupt onset of polyuria and polydipsia, followed by a well‐demarcated normal interphase, and, then, by a permanent phase of elevated water turnover. An amelioration of diabetes insipidus usually paralleled the decline in milk production after lesions, whereas hormonal replacement, particularly with ACTH and T3, restored levels of water turnover above the maximum attained acutely after lesions. Thus, the participation of adenohypophysial hormones is required for the full manifestation of diabetes insipidus

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1963.tb02742.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

摘要:

AbstractKruhøffer, P. and O. I. Nissen.Handling of glycerol in the kidney. Acta physiol. scand. 1963. 59. 284–294. —Essentially complete reabsorption of glycerol (and urine/plasma ratios below one) was observed in cats at low filtered loads. With increasing filtered loads the reabsorption rate continued to rise and the reabsorption fraction converged upon a value of about 0.4. The rate of metabolic conversion of glycerol in the kidneys – simultaneously determined from measurements of renal blood flow and arterio‐venous deficits –exceeded the reabsorption rate at low filtered loads whereas the relation was undoubtedly reversed at high filtered loads. Stop‐flow experiments indicated that the most distal parts of the nephron are sparsrly permeable to glycerol and that concentrations below that of arterial plasma may arise in proximal parts. The observations ma)‐ be accounted for on the assumptions that reabsorption at low filtered loads is predominantly a conversion reabsorption (diffusion from the tubular lumen into tubular cells maintained by a metabolic convcrsion inside the cytoplasm) and that at high filtered loads well above the level of saturation of the glycerol converting enzymes it is essentially due to transcellular back‐diffusion through the (proximal) tubular cells. I'he pattern of renal excretion of glycerol may thus be interpreted without resorting to special transmembranr tra

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1963.tb02743.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1963.tb02744.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1963.tb02745.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY