摘要:

Summary.A physiologically active volatile base has been isolated as pic‐rate from cow's urine.Qualitatively its action resembles that of nicotine on the blood pressure of the cat and rabbit, the motility of the isolated intestine of the rabbit and the respiration on the cat, though it is about 20 times weaker.The action is not abolished by cocain and is partly inhibited by ergotamine.The possible physiological significance of the occurrence in normal urine of a substance with a general synaptotropic action is pointed ou

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1944.tb03035.x

出版商:Blackwell Publishing Ltd    

年代:1944

数据来源: WILEY

摘要:

Summary.A gastric secretory excitant is isolated from the pyloric mu‐cosa of cat and pig. The agent is of protein nature.Two reliable methods for the preparation of the active principle in a relatively pure state are described. The methods involve the precipitation of HCl‐mucosall extracts with NaCl and further precipitation with tannic acid or trichloracetic acid. Inert material is removed by washing with 80 % acid alcohol and iso‐electrical precipitation at pH 8.0. Finally the active material is precipitated with trichloracetic acid.The active agent selectively activates the gastric glands, the gastric juice obtained being strongly acid but poor in pepsin. Salivary, pancreatic or bile secretion are not influenced by the agent.The gastric secretagogue shows physiological as well as chemical similarities to secretin. Identity with the supposed gastric hormone, gastrin, is pro

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1944.tb03036.x

出版商:Blackwell Publishing Ltd    

年代:1944

数据来源: WILEY

摘要:

Summary.Inhalation of carbon monoxide, producing contents of carbon monoxide haemoglobin up to 30 %, causes a diminution of dark adaptation, sometimes considerable sometimes smaller or none. It cannot be excluded that this condition may have practical significance for motorcar driving in the dark,e. g., in conjunction with dazzle when meeting.

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1944.tb03037.x

出版商:Blackwell Publishing Ltd    

年代:1944

数据来源: WILEY

摘要:

Summary.1) In the present paper different earlier methods for determination of oxaloacetic acid are mentioned.2) A method for the determination of oxaloacetic acid in biologic systems with special consideration of spontaneous decar‐boxylation is described.3) The accurary of the method is elucidated by expe

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1944.tb03038.x

出版商:Blackwell Publishing Ltd    

年代:1944

数据来源: WILEY

摘要:

Summary.The cholesterol content has hen determined in the serum of more than two hundred white land rabbits. The average value for all animals was found to be 40.8 nig per cent, the averagc value for the fernale rabbits being about 10 mg per cent higher than for male rabbitn. A report is given of experiments showing variations in the same animal froui day to day. Further the influence of different degrees of bleeding anaemia, inanition, ether narcosis and surgical operations is described.

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1944.tb03039.x

出版商:Blackwell Publishing Ltd    

年代:1944

数据来源: WILEY

摘要:

Summary.1) Fully‐nourished rats which had received plenty of calcium while growing (skim milk) show a negative chemo‐taxis for food which contains calcium in the form of lactate and citrate.2) On the other hand, if the animals are subjected to a period of calcium deprivation the negative chemo‐taxis is transformed into positive. The animals now, for some time, select predominantly the calcium

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1944.tb03040.x

出版商:Blackwell Publishing Ltd    

年代:1944

数据来源: WILEY

摘要:

Zusammenfassung.Bei drei Versuchspersonen bewirkte die tägliche Verabreichung von 3 mg Arsentrioxyd im Laufe von 23–29 Tagen keine Änderung des respiratorischen Gaswechsels und auch keine sichere Änderung des Herzminutenvolumens. Dagegen trat eine kleine Erhöhung der Pulsfrequenz während Ruhebedingung

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1944.tb03041.x

出版商:Blackwell Publishing Ltd    

年代:1944

数据来源: WILEY

摘要:

Zasammenfassung.Der Ruhegaswechsel des Meerschweinchens wurde von Natrium‐arsenat, einer Zufuhr von 1–4 mg Arsen pro kg Körpergewicht alle zwei Tage wahrend 12–14 Tage entsprechend, nicht beein‐flusst. Nach 8 mg Arsen pro kg trat dagegen eine deutliche Er‐höhung des Sauerstoffver

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1944.tb03042.x

出版商:Blackwell Publishing Ltd    

年代:1944

数据来源: WILEY

摘要:

Summary.Some attempts to isolate the thermolabile fraction of the reti‐culocyte ripening principle from dessicated hog stomach are described.This gastric factor is found dialysable and when purified very little soluble in water. It is very labile. The factor can be divided into two fractions, one soluble and one insoluble in methanol. The strongest preparation from dessiccated hog stomach contains 75 % xanthine which can be isolated from the gastrix extract.Pure synthetic xanthine has a slight ripening effect. Hypo‐xanthine, 3‐methylxanthine, 4‐amino 5 formylamino 2–6 dio‐xypyrimidine, alloxan and alloxanthine have the same effect. Little or no effect have guanine, uric acid, theobromine, theo‐phylline, coffeine, 4‐amino 2–6 dioxypyrimidine, 4–5 diamino 2–6 dioxypyrimidine and barbituric acid.When xanthine is heated dry the ripening effect is not altered, but when heated in water, the effect disappears to re

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1944.tb03043.x

出版商:Blackwell Publishing Ltd    

年代:1944

数据来源: WILEY

摘要:

Summary.It has been demonstrated that papain preparations contain an aminopolypeptidase with a substrate specificity of the same type as that of the corresponding enzyme present in the hogs pyloric and duodenal mucosa. Based on recent experimental evidence the view is advanced that the intrinsic factor of Castle may occur in certain vegetable material.The writer is indebted to the Johan and Therese Andeisson's Memorial Fund and the Ferrosan Corporation for their grants which supported the present investigation. He further acknowledges his thanks to Miss Ahlquist for her valuable assistance throughout the investigation.

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1944.tb03044.x

出版商:Blackwell Publishing Ltd    

年代:1944

数据来源: WILEY