摘要:

Summary.Two types of experiments have been performed, both of which indicate that histamme is present in plasma in bound, inactive form.The possibility is discussed that histamine might be set free during the sampling of blood through, the action of thrombokinase.

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1946.tb00360.x

出版商:Blackwell Publishing Ltd    

年代:1946

数据来源: WILEY

摘要:

Summary.Frank‐Broemser's manometer theory regarding oscillations in the aorta has been studied, and the following results have been obtained.1) “The fundamental (self) oscillation time” of the arterial pulse, as computed for 18 healthy subjects, aged 20–40 years, with different methods, gives the same values for each subject, regardless of the combinations of computation.2) BROEMSER'S supposition that the “manometer” has a constant damping factor

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1946.tb00361.x

出版商:Blackwell Publishing Ltd    

年代:1946

数据来源: WILEY

摘要:

Summary.A description of a simple apparatus for simultaneous measurement of standard metabolism and the respiratory quotient are given. The work is supplemented with investigations on normal and hypophysectomized rats.The values obtained were in good accord with earlier investigations, even though it has not been possible to demonstrate the rather considerable rise in the RQ after hypophysectomy which has been described by other authors.

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1946.tb00362.x

出版商:Blackwell Publishing Ltd    

年代:1946

数据来源: WILEY

摘要:

Summary.The fall in the glycerol concentration in the blood after oral administration of glycerol is slowed down during muscular work.This effect is assumed to be due to the liberation of glycerol from the fats metabolized during the work.If triglycerides are broken down in the working muscles, then at any rate the glycerol component is not directly oxidized in the muscles.The presence of ethyl alcohol in the blood causes a marked depression in glycerol oxidation, a further indication of the close relationship between the metabolism of the two compounds.

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1946.tb00363.x

出版商:Blackwell Publishing Ltd    

年代:1946

数据来源: WILEY

摘要:

Summary.The highly purified material from aspen leaves contains a substance or substances with reducing properties and phenol‐like character which seem to interfere with the chemical determination of thiamin by the reaction of MELNICK and FIELD. The vitamin is apparently reduced to a state which is biologically active. Thiamin which has interacted with cysteine, vitamin C or the phenol‐like leaf factor can be determined with the thiochrome method. Cysteine gives a faint blue fluorescence in the thiochrome t

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1946.tb00364.x

出版商:Blackwell Publishing Ltd    

年代:1946

数据来源: WILEY

摘要:

Summary.1 A method of fluorescence microspectrography has been elaborated for the localization of fluorescent substances normally occurring in the tissue cells.The method has primarily been utilized for cytologic localization of riboflavin and thiamin. An earlier improved method of fluorescence microscopy (SJÖSTRAND 1944) has been employed in this connection.2 Riboflavin occurs in frogs' eyes localized to the choroid membrane.3 Thiamin is localized to the myelin sheaths in the peripheral

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1946.tb00365.x

出版商:Blackwell Publishing Ltd    

年代:1946

数据来源: WILEY

摘要:

Summary.The BELL and KRANZ modification of the Knudson‐Dresbach colorimetric assay for digitalis was investigated, with the use of solutions diminishing in strength. The colorimetric method gave no adequate conception of this deterioratio

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1946.tb00366.x

出版商:Blackwell Publishing Ltd    

年代:1946

数据来源: WILEY

摘要:

Summary.Afferent impulses from the abdominal viscera have been recorded from the splanchnic nerve and from fine strands of mesenteric nerves of the cat. The Pacinian corpuscles of the exposed mesentery were found to be extremely sensitive to the most gentle pressure, such as faint puff of air.The small intestine very rarely receives any large medullated fibres, and light mechanical stimuli such as slight pressure or touch do not give rise to any inflow of impulses. Fast impulses can be elicited only from those parts of the mesentery possessing Pacinian corpuscles.Injurious stimuli such as pinching applied to the intestinal wall as well as to the mesentery produce δ‐ and C‐potentials. In addition to this, intense stimulation gives rise to large potentials waves apparently built up by slow C‐potentials.It is thus concluded that nociceptive reactions from the intestine are not produced by afferent fibers belonging to the α‐or β‐group but by δ‐ and C‐fibers only.Support is given for the view that the intestinal wall is supplied by afferent fibers able to produce nociceptive reactions in response to such mechanical stimuli which if applied to the skin, would elicit nociceptive reflexes. The sensibility of the intestine itself is thus to be looked upon as very much the same as that of the skin deprived of its fast‐conducting afferent fibers, which respond to vibratory and light mechanical stimuli as well as t

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1946.tb00367.x

出版商:Blackwell Publishing Ltd    

年代:1946

数据来源: WILEY

摘要:

Summary.Extracts have been prepared of various kinds of nerves and their content of sympathomimetic activity determined and the actions analyzed.The thoracic and lumbar sympathetic chain and the splenic periarterial nerves were especially suitable for preparation of the active substance and contained some 30–100 μg adrenaline equivalents per g as measured on the blood pressure of the cat.The active substance gives catechol reactions and bears near relations to adrenaline, but differs characteristically from this in the following respects, where a close resemblance to nor‐adrenaline was found:Blood pressure action on the cat after ergotamine or dihydroergotamine (Fig. 2–4).Action on non‐pregnant cat's uterus (Fig. 5 A), pregnant rabbit's uterus (Fig. 6) and the isolated intestine of the cat and rabbit (Fig. 7).Pupil‐dilating action (Fig. 8). Fluorescence test. The active substance occurs in higher amounts in the grey sympathetic rami than in the white rami (Fig. 10).The content is fairly high in sensory nerves of the skin but low in sympathetic ganglia, the vagus and phrenic nerves and various parts of the brain.After degeneration of the main portion of the (post‐ganglionic) periarterial splenic nerves the content of the spleen of the active substance is greatly reduced.The possible physiological significance of the solubility of the active substance in ether in the presence of phospho‐lipids is pointed out.From the experiments it is inferred that the active substance is the physiological transmitter of adrenergic nerve action in mammals and identical with nor‐adrenaline.Extracts of frogs' hearts contain an active substance with the properties of adrenaline.It is suggested that the name sympathin should be used for the ergone demonstrated in adrenergic nerves, exerting the actions of nor‐adrenaline.The relationship of the adrenergic ergone to sympathin E

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1946.tb00368.x

出版商:Blackwell Publishing Ltd    

年代:1946

数据来源: WILEY