摘要:

Abstract— The effect of estrogens upon cell division in genital and non‐genital tissues of mice has been investigated, the non‐genital tissue in vivo as well as in vitro, the genital tissue in vivo. In the in vivo experiments an increased mitotic index depending upon an increased prophase number was observed, from what it may be concluded that there is a real mitotic activation. In the in vitro experiments it was observed that the effect of estradiol upon cell division depended upon the concentration in the medium: Low concentration caused increased mitotic activity, high concentrations, on the other hand, caused a metaphase block. A difference in response to estrogens of genital and non‐genital tissue as well as a different effect upon tissue in vivo and in vitro have been o

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1962.tb02414.x

出版商:Blackwell Publishing Ltd    

年代:1962

数据来源: WILEY

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1962.tb02459.x

出版商:Blackwell Publishing Ltd    

年代:1962

数据来源: WILEY

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1962.tb02460.x

出版商:Blackwell Publishing Ltd    

年代:1962

数据来源: WILEY

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1962.tb02469.x

出版商:Blackwell Publishing Ltd    

年代:1962

数据来源: WILEY

摘要:

Abstract— The effect of oxygen lack on anaphylactic histamine release from sensitized guinea‐pig and rat lung tissuein vitrohas been investigated, and found to consist of pronounced inhibition, provided that the incubation medium (phosphate buffer) was devoid of glucose. In the presence of glucose, this inhibition was overcome progressively with rising concentrations of glucose. Under oxygen, the anaphylactic histamine release from guinea‐pig lung tissue was also enhanced by the presence of glucose. By comparing anaphylactic histamine release from guinea‐pig lung tissue and Compound 48/80‐induced histamine release from rat lung tissue in glucose‐containing phosphate buffer and Tyrode solution, respectively, it has been demonstrated that pH changes produced by gassing the Tyrode solution with oxygen and nitrogen have obscured the true effect of nitrogenation in earlier investigations performed in glucose‐containing Ty

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1962.tb02415.x

出版商:Blackwell Publishing Ltd    

年代:1962

数据来源: WILEY

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1962.tb02461.x

出版商:Blackwell Publishing Ltd    

年代:1962

数据来源: WILEY

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1962.tb02470.x

出版商:Blackwell Publishing Ltd    

年代:1962

数据来源: WILEY

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1962.tb02471.x

出版商:Blackwell Publishing Ltd    

年代:1962

数据来源: WILEY

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1962.tb02463.x

出版商:Blackwell Publishing Ltd    

年代:1962

数据来源: WILEY

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1962.tb02464.x

出版商:Blackwell Publishing Ltd    

年代:1962

数据来源: WILEY