摘要:

AbstractFreyschuss, U. and A. Holmgren.On the variation ofDlcowith increasing oxygen uptake in healthy, ordinarily untrained young men and women. Acta physiol scand. 1965.65, 193–206. ‐ Dlco, was measured at rest in supine position and during steady state exercise in sitting position at increasing oxygen uptake in 9 women and 9 men using the steady state technique. DlCO, was found to increase on transition from supine rest to sitting work increase in 4 of 5 men and 1 of 8 women. In 7 women there were only minor changes. On increasing the work load, DlCO, was found to reach an approximately constant level at a heart rate of 120 beats per minute. This value for DlCOmay be called a true “maximal” DlCOand was found to be significantly correlated to various measures of body size, the size of the cardiovascular system and the size of th

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1965.tb04263.x

出版商:Blackwell Publishing Ltd    

年代:1965

数据来源: WILEY

摘要:

AbstractHolmgren, A.On the variation ofDLCOwith increasing oxygen uptake during exercise in healthy trained, young men and women. Acta physiol. scand. 1965.65, 207–220. — DLCOwas measured during exercise in the sitting position on a bicycle ergometer, at varying loads in ten young, trained women and ten young, trained men using the steady state technique. DLCOwas found to increase hyperbolically with increasing Vo2and reached an approximate niveau at a heart rate ≪ 120 beats per min. The mean of all determinations above this heart rate was taken as a measure of the maximum DlCOfor each subject and averaged 34.8 units in the female group and 47.9 units in the male group. This value for DlCOwas highly correlated to a number of measures of body size, the dimensions of the cardio vascular system and the lungs. A significant correlation of DlCOto pulmonary and circulatory dimensions remained after elimination of body size. DlCOof the present trained group was compared with that of a corresponding untrained group with covariance analyses. DlCOin the trained group was higher than that in the untrained group. This difference was matched by a difference in body size, and dimensions of the cardiovascular system and lung volumes. The DLCOof the girls was found to be lower than that of the boys. This difference was larger than the difference in body

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1965.tb04264.x

出版商:Blackwell Publishing Ltd    

年代:1965

数据来源: WILEY

摘要:

AbstractNorberg, K.‐A.Drug‐induced changes in monoamine levels in the sympathetic adrenergic ganglion cells and terminals. A histochemical study. Acta physiol. scand. 1965.65, 221–234.— The cell bodies of peripheral adrenergic neurons in rat sympathetic ganglia have been studied and compared with the adrenergic nerve terminals in respect of drug‐induced changes in CA levels and uptake‐accumulation of CA, DOPA and 5‐HTP, using the histochemical fluorescence method of Falck and Hillarp. The cell bodies show about the same rapid depletion as the terminals following the administration of reserpine anda‐MMT but recover much more quickly. After m‐tyrosine, depletion and recovery occur rapidly and simultaneously in both parts of the neuron. The findings are in accordance with the view that the transmitter granules are formed in the cell bodies. The increased NA content observed in the superior cervical ganglion following the administration of MAO inhibitors was found to be localized predominantly to the cell bodies of the adrenergic neuron. The cells react largely as two different populations: one showing a more or less pronounced amine increase, the other no or only a slight increase. — An accumulation of CA is found in the adrenergic neuron but not in other types of peripheral neurons following the administration of DA, NA or L‐DOPA. The efficient reserpine‐insensitive mechanism for the uptake‐concentration of NA that is localized to the level of the cell membrane of the adrenergic axons and terminals (Hambergeret al. 1964, Malmfors 1965) is present also in the cell bodies. — As regards the uptake or possibly decarboxylation of DOPA and 5‐HTP, the adrenergic neuron shows a marked specificity for DOPA. — The experiments show that the cell bodies and terminals have qu

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1965.tb04265.x

出版商:Blackwell Publishing Ltd    

年代:1965

数据来源: WILEY

摘要:

AbstractHamberger, B. and K.‐A. Norberg.Studies on some systems of adrenergic synafhc teminals in the abdominal ganglia of the cat. Acta physiol. scand. 1965.65. 235–242. — The course of adrenergic fibres forming synaptic structures in certain visceral ganglia of the cat has been studied with the histochemical fluorescence method of Falck and Hillarp, after selective denervation. The adrenergic synaptic terminals in the intramural ganglia of the colon have their cell bodies in the inferior mesenteric ganglia. The same holds for most of the adrenergic muscle innervation in the bladder trigonum. The adrenergic synaptic terminals in the intramural ganglia of the bladder originate mainly in cell bodies in these or other pelvic ganglia. Adrenergic vasomotor nerves reach the bladder via the pelvic nerves. The adrenergic synaptic terminals in the inferior mesenteric ganglia are mainly of intraganglionic origin. These terminals seem to constitute important and widespread systems for the modulation of ganglionic impulse transmi

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1965.tb04266.x

出版商:Blackwell Publishing Ltd    

年代:1965

数据来源: WILEY

摘要:

AbstractHellekant, G.The effect of ethyl alcohol on non‐gustatory receptors of the tongue of the cat. Acta physiol. scand. 1965.65. 243–250. — Recordings were made of the response in the trigeminal part of the lingual nerve of the cat to the application on the tongue of alcohol, gustatory, thermal and mechanical stimuli. The summated response to alcohol revealed a slowly increasing dischargc after a latency of a few sec. The magnitude of the response increased with increasing alcohol concentrations and attained a maximum at 4 to 5 M alcohol then decreased at higher concentrations. The response of single lingual nerve fibres was also recorded. None of the fibres investigated responded to NaCl, acetic acid or quinine. All fibres responding to alcohol responded also to cooling and mechanical stimulation. The threshold alcohol concentration in the majority of these fibres was about 2.5 M. These fibres displayed a very regular discharge which reached an average maximum frequency of 38 imp/sec at 4.1 M alcohol. A reversible paralysis of the receptors was usually observed at alcohol concentrations of 4.1 M or higher. The conduction velocities of these fibres ranged from 5.7 to 18.0 m/sec. Alcohol did not stimulate myelinated mechanoceptive fibres which responded selectively to light or deep pressure on the tongue (specific mechanoceptive fibres) nor did alcohol stimulate myelinated fibres which only responded to high threshold mechanical or thermal stimulation (specific nociceptive fi

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1965.tb04267.x

出版商:Blackwell Publishing Ltd    

年代:1965

数据来源: WILEY

摘要:

AbstractØye, I.The action of adrenaline in cardiac muscle. Dissociation between phosphorylase activation and inotropic response. Acta physiol. scand. 1965.65. 251–258. — Isolated, working rat hearts were used in order to study the relationship between phosphorylase activation and inotropic response after adrenaline administration. At the maximum of inotropic response a small but consistent activation of phosphorylase was found (19.2 per cent of the total activity present in the a form, versus 5.0 per cent in the controls). A lag of about 20 sec separated the time of onset of phosphorylase activation from the time of onset of the inotropic response, phosphorylase activation being the later of the two changes and therefore unlikely to play a part in the chain of events leading to increased force of contraction. In the early phase of the inotropic response no activation of phosphorylase was found when the tissue was extracted in glycerol at 30° C. However, an activation of phosphorylase was revealed in these hearts when aqueous extraction at room temperature was carried out. Most likely this finding reflects an activation of phosphorylase b kinase during the early phase of the inotropic response. The results imply that phosphorylase activation and inotropic response might be triggered by the same initial event, in spite of the dissociation, which has been observed between these two adrenergic ef

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1965.tb04268.x

出版商:Blackwell Publishing Ltd    

年代:1965

数据来源: WILEY

摘要:

AbstractMalmfors, T.The adrenergic innervations of the eye as demonstrated by fluorescence microscopy. Acta physiol. scand. 1965.65. 259–267. — Ocular tissues from different species (mouse, rat, guinea pig, rabbit, cat and monkey) have been examined with the fluorescence method of Falck and Hillarp, which visualizes the adrenergic postganglionic sympathetic nerves. In addition to the generally accepted innervation of the vessels (particularly in the vascular layer of the eye) and of the dilator, there were found also an adrenergic innervation of the sphincter and an adrenergic ground‐plexus among the capillaries in the choroid and the ciliary body. There was not, on the other hand, found any adrenergic innervation of the retinal vessels (except in the optic papilla) and no clear innervation of the ciliary mudcle. All the adrenergic nerves to the eye seemed to arise from the upper cervical ganglion. The present observations are discussed in relation to earlier physiological and pharmacological fin

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1965.tb04269.x

出版商:Blackwell Publishing Ltd    

年代:1965

数据来源: WILEY

摘要:

AbstractBeviz, A., L. Lundholm, E. Xiohme‐Lundholrn and N. Vanios.Hydrolysis of adenosinetriphosphate and creatinephosphate on isomdric contraction of vasculur smooth muscle. Actaphysioi. scand. 1965.65. 268–272. In experiments on isolated bovine mesenteric artery the adenosinetriphosphate (ATP) and creatinephosphate (CrP) contents were determined after isometric contraction by adrenaline. 1 min after addition of adrenaline (1.10‐6) when the rise of tension was one‐half maximum, the ATP content had fallen by 0.16 ± 0.07 μmoie/g of tissue and the CrP content by 0.22 ± 0.07 μmole. At the end of 7 min, when the elevation of tension was maximal, hydrolysis of ATP amounted to 0.37 ± 0.10 μmiole and that of CrP to 0.40 ± 0.09 μmole/g of tissue. There was no definite change of the adenosinediphosphate (ADP) or adenosinemonophosphate (AMP) content. When adrenaline had exerted its action for 60 min and the tension was still at maximal level: the ATP content did not differ from that in the controls, whereas the CrP content was still reduced by 0.52 ± 0.18μmolelg of tissue. Calculation of the P.L/H quotient from the summed hydrolysis of ATP and CrP and the rise in tension during the first minute of contraction, gave a value of 9.5. This value was of similar magnitude to that found on thermoelectric determination of the heat production associated with isometric contraction of striated

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1965.tb04270.x

出版商:Blackwell Publishing Ltd    

年代:1965

数据来源: WILEY

摘要:

AbstractBuckley, J. P.Effects of synthetic angiotensin II on catecholamine levels and biological activity. Acta physiol. scand. 196565. 273–278. – Perfusion of synthetic angiotensin II did not alter the content of catecholamines in the isolated rabbit kidney and did not potentate the vasocon‐strictive effect of tyramine on the isolated perfused rabbit kidney. Angiotensin II did induce slow rhythmic alterations in perfusion pressure having a frequency of 2 to 3 per minute and pressure changes varying from 30 to 120 mm of water. Infusion of angiotensin II to anesthetized rats did not significantly alter the tissue content of catecholamines in the heart and kidney. The administration of angiotensin II via the carotid inflow to the recipient's head in dog cross circulation preparations in which the head was vascularly isolated from the trunk between C‐3 and C‐4 produced approximately a 50 % increase in the urinary excretion of adrenaline and no change in the excretion of noradrenaline in the

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1965.tb04271.x

出版商:Blackwell Publishing Ltd    

年代:1965

数据来源: WILEY

摘要:

AbstractHallberg. D.Studies on the elimination of exogenous lipids from the blood stream. The kinetics for the eliminaiion of chylomicrons studied by single intravenous injections in man. Acta physiol. scand.1965.65. 279–284. ‐ The thoracic duct was cannulated in 2 subjects and chylomicrons were collected and then given to the subjects as rapid intravenous infusions during 2 and 5 min respectively. The amounts of triglyceride (TG) infused were 0.18 and 0.26 g/kg body weight respectively. Plasma samples were drawn and analysed for TG without and with separation into 3 fractions in a polyvinylpyrrolidone density gradient. The chylomicron TG was found in the top fraction of the gradient and endogenous plasma TG in the middle and bottom fractions. The elimination curve for the chylomicrons was found to be linear at high and exponential at low TG concentrations. During the elimination the TG concentration in the middle and bottom fractions changed in a way observed earlier for an artificial fat emuls

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1965.tb04272.x

出版商:Blackwell Publishing Ltd    

年代:1965

数据来源: WILEY