ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1969.tb04425.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1968.tb04418.x

出版商:Blackwell Publishing Ltd    

年代:1968

数据来源: WILEY

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1969.tb04434.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1969.tb04426.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1969.tb04427.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1969.tb04435.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SummaryTissue thromboplastin and thrombin were infused into a femoral artery or into a central vein of dogs, and the femoral arterial blood flow and the aortic blood pressure were registered.Intra‐arterial infusion of dialyzed homologous tissue thromboplastin or purified human tissue thromboplastin had no local flow‐increasing effects. Larger amounts produced hypotension, which might have been due partly to thrombin formation.Intra‐arterial infusion of small amounts of thrombin resulted in a local flow increase, whereas larger amounts produced an initial increase, rapidly followed by a decrease. The increase in blood flow seemed to be due to vasodilatation, whereas the decrease was probably due to coagulation. Thrombin given intravenously to defibrinogenated animals caused a fall in the aortic blood pressure.Fibrinopeptides and clot supernatants from fibrinogen had no vasodilating activity. The vasodilating activity of thrombin was the same in normal as in defibrinogenated animals. It is thus improbable that products of the thrombin‐fibrinogen reaction are mediators of the thrombin‐induced vasodilatation.Large intravenous infusions of kallikrein made dogs resistant to intra‐arterially infused kallikrein and bradykinin, but not to thrombin. Large intravenous infusions of thrombin, on the other hand, made the dogs resistant to intra‐arterially infused thrombin, but not to kallikrein and bradykinin. These results, and the finding that no vasoactivity was generated during incubation of bradykininogen with thrombinin vitro, indicate that the vasodilating activity of thrombin is not mediated by plasma kinins.No vasoactivity was found after incubation of platelet‐poor plasma with thrombinin vitro.However, incubates of whole blood or platelet‐rich cell suspension with thrombin showed vasoactivity. The presence of blood cells thus seems to be of importance for the vasoact

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1968.tb04420.x

出版商:Blackwell Publishing Ltd    

年代:1968

数据来源: WILEY

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1969.tb04428.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1968.tb04422.x

出版商:Blackwell Publishing Ltd    

年代:1968

数据来源: WILEY

ISSN:0001-6772    

DOI:10.1111/j.1748-1716.1968.tb04423.x

出版商:Blackwell Publishing Ltd    

年代:1968

数据来源: WILEY