ISSN:0899-3459    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Multiple clinical trials have demonstrated the efficacy of endarterectomy in selected groups of patients based primarily on percent diameter stenosis. Although measurement of stenosis in the clinical trials was established by conventional angiography, there is considerable interest in noninvasive alternatives. Magnetic resonance angiography, performed using time-of-flight methods or with contrast enhancement, is one of several alternatives for noninvasive carotid evaluation. Screening examinations are routinely performed for carotid stenosis. Preoperative evaluations based on one or a combination of noninvasive tests have been proposed, although these proposals are the subject of ongoing controversy. Evaluation of the vertebral arteries is more difficult and less well studied; however, the increasing availability of therapies for posterior circulation atherosclerotic narrowing is resulting in increased interest in this problem.

ISSN:0899-3459    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Many of the limits to current time-of-flight (TOF) magnetic resonance (MR) angiographic methods, including flow voids from turbulent flow, flow artifacts from pulsatile flow, and oblique flow displacement, are not inherent to the TOF enhancement mechanism and will be eliminated with technological advancements. Slowly flowing blood and physiological motion will remain an obstacle to these methods, although technological advancements will improve on current methods. Future TOF MR angiographic methods will prove to be a cost-effective competitor to MR angiographic methods requiring contrast agents in many applications.

ISSN:0899-3459    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

The time-resolved contrast-enhanced magnetic resonance (MR) angiographic technique TRICKS (time-resolved imaging of contrast kinetics) reconstructs a temporal series of three-dimensional (3D) images. The temporal resolution is increased by using a short TR (<8 ms) and TE (<2 ms), zero filling, partial echo sampling, view sharing, and temporally sampling k-space at variable rates. TRICKS allows reconstruction of multiple sequential 3D volumes following bolus injection of a gadolinium chelate (0.2 mmol/kg body weight up to 40 ml, injection rate ∼2 ml/s). The resulting temporally defined datasets are conceptually similar to a catheter-based intra-arterial digital subtraction angiographic series, except that they are 3D volumes and not projection images. Similar to other contrast-enhanced MR angiographic methods, TRICKS improves delineation of carotid artery stenosis by minimizing saturation effects. TRICKS and other contrast-enhanced MR angiographic techniques use short echo times and small voxels, thus reducing intravoxel dephasing. Surface morphology of atherosclerotic plaque and slow flow in nearly occluded vessels (“string sign”) are well delineated. The major advantage of the TRICKS technique is that the timing of the acquisition in relation to the passage of the contrast bolus occurs automatically, allowing for consistent capture of the arterial phase, and eliminating the need for sophisticated synchronization methods.

ISSN:0899-3459    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Magnetic resonance (MR) angiography has undergone significant development over the past decade. It has gone from being a novelty application of MR with limited clinical use to replacing catheter angiography in some clinical applications. One of the principal limitations inherent to all MR angiographic techniques is that they remain signal limited when pushed to the limits of higher resolution and short acquisition time. Developments in magnetic gradient hardware, coil design, and pulse sequences now are well optimized for MR angiography obtained at 1.5-T main magnetic field (B-field) strength, with acquisition times and imaging matrix size near their optimal limits, respectively. Recently, the United States Food and Drug Administration (FDA) approved use of clinical magnetic resonance imaging with main magnetic field strengths of up to 4 T. Before FDA approval, use of MR with magnetic field strengths much greater than 1.5 T was essentially reserved for investigational or research applications. The main advantage of high B-field imaging is a significant improvement in the signal-to-noise ratio (SNR), which increases in an approximately linear fashion with field strength in the range of 1.5 to 3.0 T. This increased SNR is directly available when performing MR angiographic acquisitions at higher magnetic field strengths, allowing for better resolution and conspicuity of vessels with similar acquisition times. Little has been reported on the benefits of performing MR angiography at magnetic field strengths >1.5 T. The purpose of this article is to summarize our current experience with intracranial and cervical MR angiographic techniques at 3.0 T.

ISSN:0899-3459    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Magnetic resonance imaging (MRI) of carotid plaque has undergone significant improvements in the last decade. Early studies utilizing ex vivo specimens and spin-echo or fast spin-echo imaging led to the conclusion that T2 weighting is the best single contrast to characterize carotid plaque morphology. On these images, the fibrous plaque appears bright and the lipid core is dark; thrombus can have variable intensity. There can be an overlap in T2-weighted signal intensities among the various plaque components, which can be partially offset by the use of multispectral analysis of multiple contrast images. With improvements in coil design, sequence design, and main field and gradient capabilities, accurate in vivo differentiation and measurement of these various carotid plaque components should be possible in 3 to 5 years. Ex vivo and in vivo studies have yielded high-resolution measurements of the complex three-dimensional lumen geometry, which are being used to predict hemodynamic forces acting on the lumenal surface. Carotid plaque burden can be accurately measured in vivo today; ongoing longitudinal studies should lead to a better understanding of the relationship between plaque burden and the risk of thromboembolic complications, as well as the effect of diet and drug therapy in hyperlipidemic patients. With these developments in place or soon to be available, MRI of the diseased carotid artery wall may prove to be even more important than magnetic resonance angiography.

ISSN:0899-3459    

出版商:OVID    

年代:2001

数据来源: OVID