摘要:

An HLA‐Bw45 serum (Mu46), which was produced by pregnancy in a Bw44 positive woman, is described. The serum was unable to be absorbed by Bw44 positive cells. Blocking tests employing broad B12 (Bw44 + Bw45) antisera, stimulated by either Bw44 or Bw45, showed that only F(ab)2 from Bw45‐stimulated B12 sera would completely block the cytotoxicity of this serum. It was concluded that Bw44 and Bw45 are distinct specificities which share common determina

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1980.tb00888.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

A study of the distribution of histocompatibility (HLA) antigens in patients with Raynaud's phenomenon (RP) is presented, based upon the analysis of RP patients with and without connective tissue disease (CTD). In all patients, the phenomenon preceded the other symptoms of CTD by several years. The RP patients with CTD showed a significantly increased frequency (59%) of HLA‐B8 compared with the frequency (23%) of that same antigen in the Dutch population. The RP patients without CTD showed no significant difference in frequency of HLA‐B8. At least 50% of the patients with RP and HLA‐B8 develop a CTD versus 18% of the patients without HLA‐B8. It is suggested that HLA testing in patients with isolated RP may help to distinguish the patient in whom RP is the first symptom of CTD from the patient with truly pri

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1980.tb00889.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

HLA antigen frequencies were investigated in 115 patients with congenital rubella syndrome and 93 of their mothers in the Ryukyu Islands, Japan. A high frequency of HLA‐B15 and a low frequency of HLA‐Bw22 were found in the mothers. HLA‐B15 was associated with high antibody responsiveness to rubella vaccine in our previous study, whereas HLA‐Bw22 was one of the HLA antigens which showed low antibody responsiveness. There was no association between HLA antigens and viral replication in rubella vaccine recipients in the present study. These results indicate that an HLA‐linked genetic background in the mothers is related to susceptibility to congenital rubella syndrome, and that the mechanism of the relation may be mediated via immune respo

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1980.tb00890.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

In Indian patients with Multiple Sclerosis it was observed, upon testing for serum determinable histocompatibility antigens, that HLA‐B12 antigen was present in excess (77.7%), in comparison with normal controls (13.8%). In fact, in the sub‐group of ‘clinically definite’ patients, the B12 antigen excess was remarkable (84%). These preliminary findings seem to point to a different immunogenetic profile of Indian MS patients in comparison with Western and Japanese series. Relevant published information relating to the HLA‐B12 alleles in disease processes is discussed in order to provide a basis for fur

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1980.tb00891.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1980.tb00892.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1980.tb00893.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1980.tb00894.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY