摘要:

A new approach which presumably recognizes MLC determinants (or at least structures closely linked to MLC and different from the FOUR, A J and LA series determinants) by serology is described.As the test can be performed within 10 h it could be used to match cadaveric kidney donors for these MLC determinants. Perhaps even more important is the fact that the antibodies detected by this technique could be used to study the immunochemistry of a class of determinants differing from the well known SD determinants.

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb00532.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

The frequencies of 30 HL–A antigens were studied in an Indonesian population of 95 individuals from the city of Jakarta. The antigens HL–A9, or more precisely W24, and HL–All (first series) and W15 (second series) occurred with high frequencies, whereas HL–A8, W14 and W22 were completely absent. These results are consistent with previous reports of HL–A typing in South East Asian po

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb00533.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

HL–A antigens of 70 leprosy patients and 40 normal healthy individuals were determined by the standard microlymphocytotoxicity test. Both lepromatous and non‐lepromatous leprosy patients were tested for the presence of 11 HL–A antigens, and the frequency of each specificity was compared with that in a normal population of the same ethnic group. Although the statistical significance of HL–A8 specificity was found to be marginal in lepromatous leprosy patients, when using ordinary 2x2 statistics, there did seem to be a decreased frequency of HL–A9 among the non‐lepromatous type. Other antigens tested did not reveal any significant differences between the two groups

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb00534.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

HL–A typing of cadaver kidney cell suspensions by fluorochromasia cytotoxicity was successful in 76 out of 124 cases. In the 44 cases with confirmed phenotypes, 24 had identical results for lymphocytes and kidney cells. Twenty kidney cells had HL–A antigens not detected on that donor's lymphocytes, most commonly HL–A7 and HL–A8. In eight of these 20 cases, the additional kidney antigens brought the total to more than two per segregant series, in disagreement with an earlier report from this laboratory. The discrepancy was traced to a‘change in the method of complement preparation. The complement was successfully deprived of the resulting non‐specific cytotoxicity for kidney cells by absorption with human red blood cells. Prior to absorption, the complement had rendered kidney cells susceptible to the lytic effect of anti‐A and B red cell antibodies. Using the absorbed complement, a patient who had hyperacutely rejected two cadaver kidneys provided sera with an antibody reacting with, and absorbed by, the kidney cells but not the lymphocytes

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb00535.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Three cases of crossing over between the LA and FOUR loci of HL–A system are presented in this note. Recombination fractions between those two loci are also calculated from familial data kindly provided by other European laboratories. It is suggested that differences found in maternal and paternal recombination frequency are due to the heterogeneity of estimates of each laborator

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb00536.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

A quantitative microabsorption technique has been used to determine a gene dosage effect on HL–A. This allows homozygosity or heterozygosity of HL–A antigens to be determined prospectively in cadaver donors of renal allografts where less than four antigens were detected by standard lymphocytotoxicity. This in turn provides more precise matching of donor and recipi

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb00537.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

The existence of two allelic determinants, subtypic to W28 (named TO 54 and TO 55), and of an antibody cross‐reacting W28 × HL–A10, is demonstrated. These new determinants have been studied by means of population and family studies and with the following serological techniques: absorption, elution, lysostrip and blocking by F(ab')2fragment. The results suggest that determinants TO 54 and TO 55 are very similar each other and are spatially close to the supertypic fa

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb00538.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

The purpose of this investigation was to see whether or not the hypothetical disease susceptibility locus to ankylosing spondylitis is linked to the MLC determinant 27a. Firstly, we discovered a strong MLC determinant which we called 27a because of its association with the second series specificity W27. Later, we found that this determinant was the same as that which Jorgensen et al. (1973) found to be associated with the second series specificity W5. These MLC determinants may, therefore, be in linkage disequilibrium with more than one HL–A specificity (in this case, of the second series) as previously described by Dupont et al. (1973). However, we found no association between 27a and ankylosing spondylitis.On the other hand, we confirmed the association of ankylosing spondylitis with W27 and also found an increase of HL–A2 of the first series which, however, was not statistically significant. In view of the high incidence of HL–A2 in the general population, more information is required to definitely establish such an association. We found no special association with specificities A J and Hu (Sa 532), third series antigens, but confirmed their linkage disequilibrium with W27.Disease predisposition loci seem, therefore, to be associated with either type of MHS marker, multiple sclerosis and MLC determinant 7 a, or ankylosing spondylitis and the second series antigen W27. It will be interesting to discover whether there is any special significance of the association of one marker rather than an

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb00539.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb00540.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

A high association of HL–A27 specificity with ankylosing spondylitis was found in Japanese patients in spite of a very low frequency of this specificity in a normal Japanese population. These findings coincide well with those in Caucasian patients, and indicate the strong relationship between the susceptibility to ankylosing spondylitis and HL–A27 specificity beyond racial differences.No particular HL–A patterns were noted in patients with the ossification of the posterior longitudinal ligament of the cervical vertebrae. This observation provides an evidence that this disease is etiologically different from ankylosing spondy

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb00541.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY